Repozytorium URgeneral-feed.descriptionhttps://repozytorium.ur.edu.pl2024-03-29T16:00:41Z2024-03-29T16:00:41Z94581The content of lactoferrin and interleukin-8 in breast milk of patients with lactational mastitisDemianchuk, NataliiaAkimova, ViorikaSoyka, LarysaShchurko, MariiaLapovets, LyubovLutsiv, NataliiaTkachuk, SerhiiBuchko, OlhaZubchenko, SvitlanaHayduchok, Ihorhttps://repozytorium.ur.edu.pl/handle/item/103652024-03-29T02:00:53Z2024-03-01T00:00:00Zdc.title: The content of lactoferrin and interleukin-8 in breast milk of patients with lactational mastitis
dc.contributor.author: Demianchuk, Nataliia; Akimova, Viorika; Soyka, Larysa; Shchurko, Mariia; Lapovets, Lyubov; Lutsiv, Nataliia; Tkachuk, Serhii; Buchko, Olha; Zubchenko, Svitlana; Hayduchok, Ihor
dc.description.abstract: Introduction and aim. Information concerning lactoferrin and interleukin-8 (IL-8) local levels in breast milk are not numerous and requires further research. The aim of this study was to determine the content of lactoferrin and interleukin-8 in the breast milk of patients with lactational mastitis, and to identify new potential markers for assessing the activity of the inflammatory process in the mammary gland.
Material and methods. This study analyzed the breast milk of 30 women with lactostasis (group I), 37 women with lactational mastitis (group II) and 30 healthy lactating women (age 26±5 years old). The milk content of lactoferrin and interleukin-8 (IL-8) was determined by enzyme-linked immunosorbent assay.
Results. The average value of lactoferrin in breast milk of healthy women was 4.78±0.47 mg/mL, exceeding levels in group I 1.8 times (p<0.05). The level of lactoferrin in group II exceeds the control values 3.1 times (p<0.05). The content of IL-8 in breast milk of women in group I was 7.3 times higher than the control (3.63±0.12 pg/mL, p<0.05). In lactational mastitis, the concentration of IL-8 in breast milk exceeded the group I 13.9 times (p<0.05) and was 1.9 times higher than group I (p<0.05).
Conclusion. The analysis has revealed an increase of lactoferrin and IL-8 in breast milk of the test groups, which indicates the activation of non-specific protection.
dc.description: All subjects gave their informed consent for inclusion before they participated in the study. The study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of Danylo Halytski Lviv National Medical University, Ukraine (meeting minutes No. 2 dated February 15, 2016).
2024-03-01T00:00:00ZHemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort studyStepanova, NataliaRysyev, AndriySnisar, Lyudmylahttps://repozytorium.ur.edu.pl/handle/item/103642024-03-29T02:01:34Z2024-03-01T00:00:00Zdc.title: Hemodialysis dose and long-term COVID-19 outcomes – a retrospective cohort study
dc.contributor.author: Stepanova, Natalia; Rysyev, Andriy; Snisar, Lyudmyla
dc.description.abstract: Introduction and aim. Long-term outcomes of COVID-19 pose a global challenge, particularly impacting individuals with un derlying health conditions, including those who have undergone hemodialysis (HD). The study aimed to investigate the rela tionship between preexisting dialysis dose, measured by single pool Kt/V (spKt/V), and long-term outcomes of COVID-19 in patients undergoing HD.
Material and methods. Demographic, clinical, and laboratory parameters following COVID-19 recovery, and long-term out comes, including the presence of COVID-19 sequelae, hospitalization, and all-cause mortality during a year after COVID-19 were retrospectively analyzed.
Results. Out of the 195 patients included, there were 108 males (55.4%) and 87 females (44.6%), with a median age of 56 (44-63) years and a dialysis duration of 49 (31.3–85.2) months. Patients with spKt/V<1.4 had a significantly increased risk of long-term COVID-19 sequelae (HR 9.1, 95% CI: 3.4; 24.6), hospitalization (HR 7.6, 95% CI: 3.9; 14.6), and all-cause mortality (HR 8.5, 95% CI: 2.9; 25.8) within one year after COVID-19 recovery compared with those with spKt/V≥1.4. spKt/V cutoff point of ≤1.3 emerged as a significant risk factor for one-year hospitalization and mortality within our cohort.
Conclusion. Suboptimal dialysis dose, as indicated by spKt/V < 1.4, is associated with adverse long-term COVID-19 outcomes in patients undergoing HD. Optimizing dialysis adequacy may mitigate these risks. Further research is needed to validate these f indings and explore interventions to improve outcomes in this vulnerable population.
dc.description: The study protocol was approved by the Ethics Committee of the State Institution “Institute of Nephrology of the National Academy of Medical Sciences”, Kyiv, Ukraine (protocol number: 2-2021, dated April 6, 2021).
2024-03-01T00:00:00ZUnveiling challenges in cadaveric dissection for medical education – a study of student perspectivesK., SudhaJames, JerinNatarajan, Pratheepa SivasankariSubramanian, Sundara Pandianhttps://repozytorium.ur.edu.pl/handle/item/103632024-03-29T02:01:02Z2024-03-01T00:00:00Zdc.title: Unveiling challenges in cadaveric dissection for medical education – a study of student perspectives
dc.contributor.author: K., Sudha; James, Jerin; Natarajan, Pratheepa Sivasankari; Subramanian, Sundara Pandian
dc.description.abstract: Introduction and aim. Cadaveric dissection is the mainstay of learning anatomy by medical students. Even though newer teaching learning methodologies have been implemented to facilitate learning anatomy, cadaveric dissection remains the most preferred method by students. The objective of this study was to analyze the student perspective of different aspects of learning anatomy with their positive and negative experiences and to get a better understanding of their opinions and their experience.
Material and methods. In this cross-sectional study, a pretested and validated questionnaire was used to collect information from the students after approval from the Institutional Ethics Committee. Informed consent was obtained from every student prior to their participation in the study.
Results. Three hundred seventy-seven students took part in this study and the response rate obtained was 63.5%. The majority of the students stated that cadaveric dissection has helped them in learning basic anatomy and had deepened their under standing of complexity of human body and has helped in better performance in clinical applications. The smell of formalde hyde and eye irritation was cited as the major reasons for finding dissection sessions challenging. Most of the students agreed that counselling before dissection sessions will help to alleviate the emotional reactions to cadavers.
Conclusion. The students unanimously agreed that cadaveric dissection sessions are the best way to learn basic anatomy com plemented with newer teaching tools like prosection and computer-based approaches. However, the problems encountered by the students like smell and irritation of formaldehyde need to be addressed with usage of alternative techniques.
dc.description: This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of SRM Medical College Hospital & Research Centre, SRM Institute of Science and Technology No. 2179/IEC/2020.
2024-03-01T00:00:00ZIdentification of Brucella melitensis from camel’s blood by vitek2 and real time polymerase chain reactionManivannan, KavithaRamasamy, MalathiSundaresan, UmaMoustafa, Samar M.SherloumayMariyam, Safnahttps://repozytorium.ur.edu.pl/handle/item/103622024-03-29T02:00:39Z2024-03-01T00:00:00Zdc.title: Identification of Brucella melitensis from camel’s blood by vitek2 and real time polymerase chain reaction
dc.contributor.author: Manivannan, Kavitha; Ramasamy, Malathi; Sundaresan, Uma; Moustafa, Samar M.; Sherloumay; Mariyam, Safna
dc.description.abstract: Introduction and aim. Brucellosis is a zoonotic disease. Experimental clinical and laboratory diagnosis is still facing problems in identifying the organism. The present study will diagnose a Brucella infection in camel blood in Qatar using serological assays. Isolation and identification were performed on a camel blood sample. Brucella in bacterial isolates was determined by real-time polymerase chain reaction (RT-PCR) as a gold standard test.
Material and methods. A total of 220 samples, 200 random serum samples, and 20 EDTA blood samples were selected among the above-mentioned random samples, and 20 serum samples from camel handlers were collected from Al Shahaniya prov ince, Qatar. The Rose Bengal test (RBT), buffered antigen plate agglutination test (BAPAT), and enzyme linked immunosorbent assay (cELISA) for the monoclonal antibody in serum samples were performed using commercially available kits. For the molecular detection of Brucella, conventional PCR and real-time PCR (GPS kit) were used for the genus-specific insertion sequence IS711. Brucella melitensis (MICROBOSS Hightech GmbH kit) was used to identify subspecies.
Results. The results identified by vitek2 compact (30%) showed B. melitensis in 6 samples out of 20 isolates. Both conventional (66.67%) and RT-PCR (83.33%) analyses supported this, demonstrating the presence of Brucella. These tests also showed that Brucella species were present in Rose Bengal 182/200 (91%), BAPAT 182/200 (91%), and cELISA (90%) 180/200 in camel serum.
Conclusion. To conclude, the prevalence of brucellosis in dromedary camels is higher in this region, and as a matter of urgency, measures should be taken to control the disease.
dc.description: Experiment has been approved by administration of Tharb camel Hospital.
2024-03-01T00:00:00ZSurgical management of upper cervical esophagus stricture caused by ingestion of corrosive substances – a single-center experienceMishra, Haris ChandraMohapatra, JyotiranjanDash, SashibhusanDash, Sanghamitrahttps://repozytorium.ur.edu.pl/handle/item/103612024-03-29T02:01:02Z2024-03-01T00:00:00Zdc.title: Surgical management of upper cervical esophagus stricture caused by ingestion of corrosive substances – a single-center experience
dc.contributor.author: Mishra, Haris Chandra; Mohapatra, Jyotiranjan; Dash, Sashibhusan; Dash, Sanghamitra
dc.description.abstract: Introduction and aim. Corrosive strictures of the upper cervical esophagus and hypopharynx are hard to treat in the operating room because there is a high chance of aspiration during swallowing after a high-up or proximal esophageal anastomosis. In this cases, we aimed to evaluate the role of intraoperative dilatation of the proximal hypopharyngeal and cervical esophageal stumps during surgery.
Material and methods. Patients who underwent surgery and had upper cervical esophageal and hypopharyngeal strictures from corrosive substance ingestion were included.
Results. Out of total 27 patients, 10 had a cricopharyngeal or proximal cervical esophageal stricture with a long segment tho racic esophageal stricture that was treated with intra-operative dilatation (IOD) of the proximal hypopharyngeal stump. IOD was done in two cases with Hegar’s dilator and in three cases with wire-guided Savary Gillard dilators. In 74% (20/27) of the cases, the colon was frequently used as an esophageal substitute, while the stomach was only used in 10 cases. On follow-up, none of them developed repeated aspirations or required a tracheotomy.
Conclusion. IOD of the proximal hypopharyngeal and cervical esophageal stumps during surgery for corrosive upper cervi cal esophageal or cricopharyngeal strictures helps to save the proximal stump and avoid frequent hospital stays and multiple surgeries.
dc.description: All subjects gave their informed consent for inclusion before they participated in the study (001/NEW/EC/INST/2023/15947). The study was conducted in accordance with the Declaration of Helsinki.
2024-03-01T00:00:00ZExpression of vascular endothelial growth factor and microvessel density in oral squamous cell carcinoma and its correlation with various clinico-pathological parametersPanigrahi, RanjitaJha, Narendra KumarHota, Subhransu Kumarhttps://repozytorium.ur.edu.pl/handle/item/103602024-03-29T02:01:19Z2024-03-01T00:00:00Zdc.title: Expression of vascular endothelial growth factor and microvessel density in oral squamous cell carcinoma and its correlation with various clinico-pathological parameters
dc.contributor.author: Panigrahi, Ranjita; Jha, Narendra Kumar; Hota, Subhransu Kumar
dc.description.abstract: Introduction and aim. Angiogenesis, which is accomplished by capillary sprouting, is the process by which new vessels are created from pre-existing ones. In tumor, once their initial blood supply is depleted, a tumour is unable to grow without additional blood flow. Additionally, a tumor’s microvasculature, or microvessel density (MVD), increases along with its capacity to produce angiogenesis. We aimed to observe the relationship between the expression of vascular endothelial growth factor (VEGF) and MVD (using CD34) in oral squamous cell carcinoma (OSCC).
Material and methods. The expression of VEGF and CD34 antibodies was analysed using immunohistochemistry method on 50 cases of histopathologically proved OSCC. The expression was correlated with clinicopathological parameters.
Results. A significant correlation was observed between VEGF expression and gender, LVSI. No correlation between any other factors and the difference in VEGF expression was statistically significant. Similarly, the MVD expression was not found to be statistically significant in any of the pathological parameters.
Conclusion. VEGF positivity as well as MVD were found to be independent of the tumor pathology. Tumor MVD was found to be independent of the expression of VEGF. Further studies in a larger study group may establish a significant association so that antiangiogenic targeted therapy may be initiated.
dc.description: The approval of the Ethics Committee was obtained before initiation of the study (meeting date; 18/06/2021, decision number; 2021/3309). All procedures performed in this study involving human participants were in accordance with the ethical standards specified by the institutional and national research committee and with the Helsinki Declaration and its later amendments or comparable ethical standards.
2024-03-01T00:00:00ZEffect of clinic-based and telemonitored home-based intervention on pain intensity, functioning and quality of life in patients with knee osteoarthritisOjoawo, Adesola OjoOdesanya, OluwaseunKunuji, KayodeMbada, Chidozie EmmanuelAdedeji, Oluwafemi Olusesanhttps://repozytorium.ur.edu.pl/handle/item/103592024-03-29T02:01:47Z2024-03-01T00:00:00Zdc.title: Effect of clinic-based and telemonitored home-based intervention on pain intensity, functioning and quality of life in patients with knee osteoarthritis
dc.contributor.author: Ojoawo, Adesola Ojo; Odesanya, Oluwaseun; Kunuji, Kayode; Mbada, Chidozie Emmanuel; Adedeji, Oluwafemi Olusesan
dc.description.abstract: Introduction and aim. The study assessed and compared the effects of clinic-based and telemonitored home-based interventions on pain intensity, functioning and quality of life in patients with knee osteoarthritis (KOA).
Material and methods. Forty-two patients were recruited purposely and randomly allocated into clinic-based (CBG) and telemonitored home-based group (THG) equally. The CBG and THG received isometric exercises to strengthen the quadriceps and hamstring muscles using theraband. THG received the exercise at home they were monitored on phone thrice in a week, while the CBG did the exercise in the hospital. The subjects performed four sets of eight repetitions three days in a week for eight weeks. Pain intensity, functioning and health related quality of life (HRQoL) were assessed at pretreatment, 6th and 8th week of intervention. Data was analyzed with descriptive and inferential statistics. Alpha level was set at 0.05.
Results. There was a significant reduction (p<0.001) among pre-treatment, 6th and 8th week intervention in pain intensity, functional pain intensity and quality of life of CBG and THG. CBG showed significant reduction (p<0.001) in pain intensity, function and increase in HRQoL than THG at 8th week.
Conclusion. Clinic-based and telemonitored home-based interventions were both effective in the management of KOA but clinic-based intervention was better than telemonitored home-based intervention.
dc.description: Ethical approval was obtained (ERC/2021/07/15) from the Health Research and Ethics Committee of Institute of Public Health, Obafemi Awolowo University Ile-Ife, Nigeria and Department of Planning Research and Statistics, Ogun state Ministry of Health.
2024-03-01T00:00:00ZAssessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum StateAl-Tayeb, Al-Noor OpiedAbubakr, Mohammed HayatiElrheima, Hafsa AhmedHabbani, Ahmed KhalidElrasul, Rami Y. Hassabhttps://repozytorium.ur.edu.pl/handle/item/103582024-03-29T02:01:38Z2024-03-01T00:00:00Zdc.title: Assessment of serum creatinine, urea, and aminotransferase levels among methamphetamine addicted individuals in Khartoum State
dc.contributor.author: Al-Tayeb, Al-Noor Opied; Abubakr, Mohammed Hayati; Elrheima, Hafsa Ahmed; Habbani, Ahmed Khalid; Elrasul, Rami Y. Hassab
dc.description.abstract: Introduction and aim. Methamphetamine-use disorder is a pressing global public health issue. In Sudan, the escalating meth amphetamine (METH) consumption has become a significant social and health problem. This study aims to evaluate liver and kidney biomarkers in methamphetamine addicts in Khartoum state
Material and methods. The study was an analytical prospective cross-sectional hospital-based study. One hundred partici pants were enrolled in this study, fifty were cases (methamphetamine addicts), and others were healthy non-METH users as a comparative group.
Results. METH users had a mean age of (27±7) years and had been using METH for an average of (14±9) months. Urea and cre atinine levels were also significantly elevated in METH users compared to non-users, with p<0.001 and p=0.044, respectively. Their aspartate transaminase (AST) and alanine transaminase (ALT) levels were significantly higher compared to non-users, with p<0.001.
Conclusion. There was significant increases in creatinine, urea, and aminotransferases levels in the case group. ALT showed a moderate positive correlation with abuse duration, while AST showed no significant correlation. Urea and creatinine levels had strong and moderate positive correlations with abuse duration, respectively.
dc.description: The study was approved by the ethical committees of the University of Medical Sciences and Technology (IRB UMST/EG/2022/18, approval date 11/01/2022). Verbal consents were obtained from all participants, and approval was granted by the hospital administration through the office of the medical director.
2024-03-01T00:00:00ZDeterminants of distress levels in high-risk pregnant women – cross-sectional studyKara, PınarNazik, EvşenÇerçer, Zehrahttps://repozytorium.ur.edu.pl/handle/item/103572024-03-29T02:01:27Z2024-03-01T00:00:00Zdc.title: Determinants of distress levels in high-risk pregnant women – cross-sectional study
dc.contributor.author: Kara, Pınar; Nazik, Evşen; Çerçer, Zehra
dc.description.abstract: Introduction and aim. Global and national care recommendations indicate that women with high-risk pregnancies should receive personalized and qualified care during this period. This study was conducted to determine the distress levels in high-risk pregnant women and affecting factors.
Material and methods. The cross-sectional this study was conducted with total of 416 high-risk pregnant women who met the inclusion criteria in the obstetrics clinic of a training and research hospital. The study data were collected with data collection form and “Tilburg Pregnancy Distress Scale (TPDS).”
Results. The mean TPDS total score of high-risk pregnant women was 18.25±6.85. It was found that planning pregnancy, gravida, and diagnosis of gestational hypertension, systemic diseases, and gestational diabetes in the present pregnancy was asso ciated with pregnancy-specific distress (p<0.05; β=0.291, β=0.158, β=0.272, β=0.137, β=0.116, respectively).
Conclusion. It is advised that health professionals assess the distress levels of high-risk pregnant women and give personalized care during prenatal period.
dc.description: The study was started after receiving ethics committee approval from the Non-Experimental Research Ethics Committee and written permission from the Provincial Health Directorate (decision no: 2017/61-35, date: February 10, 2017).
2024-03-01T00:00:00ZBehaviors of pregnant women regarding travel – the case of TürkiyeErciyas, Şeyma KilciEkrem, Ebru CirbanDemir, RukiyeAköz, Gizemhttps://repozytorium.ur.edu.pl/handle/item/103562024-03-29T02:00:44Z2024-03-01T00:00:00Zdc.title: Behaviors of pregnant women regarding travel – the case of Türkiye
dc.contributor.author: Erciyas, Şeyma Kilci; Ekrem, Ebru Cirban; Demir, Rukiye; Aköz, Gizem
dc.description.abstract: Introduction and aim. With the development of transportation facilities and options, people can now travel easily. With women having a greater presence in the workforce, pregnant women can work until the eighth week before childbirth. This study was conducted to examine the behaviors of pregnant women regarding travel.
Material and methods. The data for this cross-sectional and descriptive study were collected from 519 pregnant women who voluntarily participated in the research and met the research criteria. The data were analyzed using the SPSS 24 software package.
Results. The average age of the participating pregnant women was 27.49±0.17, with 63.8% residing in urban areas, 74.8% be ing primiparous, and 47.6% being in the third trimester of pregnancy. A decrease in travel and car usage during pregnancy. The use of bus, train/tram/metro, taxi, bicycle/scooter, and motorcycle decreased during pregnancy, while use of car, plane, and ship/ferry increased. 81.9% of women always wore a seat belt during pregnancy. There was a statistically significant difference between the educational level of women and their car usage (p<0.005). It was found that women wore seat belts more frequently in the third trimester. As the number of pregnancies increased, the frequency of seat belt usage decreased.
Conclusion. A decrease in the frequency of travel was observed among women during pregnancy. The levels of seat belt usage and correct seat belt fastening were unsatisfactory.
dc.description: Permission was obtained from the Institutional Review Board of the researcher’s affiliated university (Date: 27.11.2020, No: 2014/08-13) for the implementation of the study. Informed voluntary consent was obtained from the participating pregnant women.
2024-03-01T00:00:00Z