The significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice

Obrazek miniatury
Data
2018
Autorzy
Kubrak, Tomasz
Podgórski, Rafał
Aebisher, David
Gala-Błądzińska, Agnieszka
Tytuł czasopisma
ISSN
Tytuł tomu
Wydawnictwo
Wydawnictwo Uniwersytetu Rzeszowskiego
Abstrakt
Introduction. Despite advances in medical care AKI (acute kidney injury) is associated with high morbidity and mortality. The lack of adequate early renal injury biomarkers is often a problem for an early AKI diagnosis. In recent years, numerous scientific studies have been carried out which reveal new urine and serum markers to assess the period of the kidney injury before revealing its late clinical effects. In most clinical settings, AKI is due to acute renal tubular necrosis which results in protein accumulation in urine. Determination of the concentrations of proteins such as NGAL (neutrophil gelatinase-associated lipocalin) and KIM-1 (kidney injury molecule-1) are of great significance in the diagnosis of AKI. Aim. The purpose of the study was to review the literature about significance of NGAL and KIM-1 proteins for diagnosis of acute kidney injury (AKI) in clinical practice. Materials and method. Analysis of Polish and foreign literature.
Opis
Słowa kluczowe
NGAL proteins , KIM-1 proteins , acute kidney injury (AKI)
Cytowanie
European Journal of Clinical and Experimental Medicine T. 16, z. 1 (2018), s. 28–33