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19F MRI As a tool for imaging drug delivery to tissue and individual cells

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dc.contributor.author Bober, Zuzanna
dc.contributor.author Aebisher, David
dc.contributor.author Ożóg, Łukasz
dc.contributor.author Tabarkiewicz, Jacek
dc.contributor.author Tutka, Piotr
dc.contributor.author Bartusik-Aebisher, Dorota
dc.date.accessioned 2017-12-12T10:06:37Z
dc.date.available 2017-12-12T10:06:37Z
dc.date.issued 2017
dc.identifier.citation European Journal of Clinical and Experimental Medicine T. 15, z. 2 (2017), s. 109–119 pl_PL.UTF-8
dc.identifier.issn 2544-2406
dc.identifier.uri http://repozytorium.ur.edu.pl/handle/item/3187
dc.description.abstract Over the past few decades, magnetic resonance imaging (MRI) has proven to be extremely successful in medical applications. More recently, the biomedical applications of MRI have been gaining more use in the field of clinical pharmacy. In 1977, perfluorocarbon compounds (PFC), which form emulsions that can carry drugs, were analyzed by 19F MRI and emulsified PFC compounds have been investigated as potential blood substitutes since the early 1960s and now a wide variety of PFC compounds are currently available as 19F MRI biomarkers. Molecules with 19F substituents are particularly attractive for use in drug tracking by 19F MRI due to 100% 19F abundance, high 19F MRI sensitivity (0.83 relative to 1H MRI) and an impressively large chemical shift range (400 ppm). Another benefit in the use of 19F MRI is a zero background signal in biological samples due to lack of endogenous fluorine. Therefore, drugs containing fluorine atom have potential for 19F MRI imaging drug delivery to tissue. This article will review recent developments in the use of 19F MRI in imaging drug delivery to tissue and individual cells. pl_PL.UTF-8
dc.language.iso eng pl_PL.UTF-8
dc.publisher Wydawnictwo Uniwersytetu Rzeszowskiego pl_PL.UTF-8
dc.rights Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska *
dc.rights.uri http://creativecommons.org/licenses/by-nc-nd/3.0/pl/ *
dc.subject drug delivery pl_PL.UTF-8
dc.subject drug tracking pl_PL.UTF-8
dc.subject fluorine pl_PL.UTF-8
dc.subject magnetic resonance imaging pl_PL.UTF-8
dc.title 19F MRI As a tool for imaging drug delivery to tissue and individual cells pl_PL.UTF-8
dc.type article pl_PL.UTF-8
dc.identifier.doi 10.15584/ejcem.2017.2.3
dc.identifier.eissn 2544-1361


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Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska Except where otherwise noted, this item's license is described as Uznanie autorstwa-Użycie niekomercyjne-Bez utworów zależnych 3.0 Polska

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