European Journal of Clinical and Experimental Medicine T.22, z. 2 (2024)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/10593

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A sight into the pathogenesis and treatment of thyroid-associated ophthalmopathy
(Publishing Office of the University of Rzeszow, 2024-06) Krzemienowska-Cebulla, Aleksandra; Puziewicz-Krzemienowska, Małgorzata; Dorochowicz, Mateusz; Matus, Iwona
Introduction and aim. Thyroid-associated ophthalmopathy (TAO), often referred to as thyroid eye disease or Graves’ ophthalmopathy, is a syndrome characterized by autoimmune inflammation affecting the eye muscles, connective tissue, and orbital fat. The aim of this literature review is to present TAO and integrate the available data in the literature regarding the pathogenesis and treatment methods. Based on these, the authors aim to examine whether, despite the extensive knowledge already available on TAO, there are still issues to be investigated. Material and methods. In this literature review, books and scientific publications in both Polish and English languages have been assessed. The search criteria included keywords such as TAO, Graves’ disease, thyroid-associated ophthalmopathy. The evaluation covered the following databases: PubMed, Scopus, Google Scholar. Analysis of the literature. Typically, the eyeball is not involved, but in exceptional cases, corneal ulceration may occur, or inflammation of the optic nerve may ensue. TAO most commonly occurs in the course of hyperthyroidism in Graves’ disease, involving up to 25–50% of cases. The coexistence of autoantigens shared between the thyroid and orbital tissues is considered the primary cause of TAO when it occurs concurrently with hyperthyroidism, later in its course, or even preceding the manifestation of hyperthyroidism, with or without concurrent thyroid dysfunction. TAO is generally bilateral, although dominance on one side is often observed. Common symptoms include eye pain, photophobia, diplopia, varying degrees of proptosis, and impaired vision. The cornerstone of treatment lies in managing hyperthyroidism, as TAO cannot be cured without it. Conclusion. First-line treatment involves glucocorticoids, with radiation therapy as a supplementary option, and in cases unresponsive to pharmacological treatment, surgical intervention may be necessary.
A study of etiological spectrum in 106 cases of pancytopenia
(Publishing Office of the University of Rzeszow, 2024-06) Singhal, Parul; Mittal, Adreena; Dixit, Ritvija
Introduction and aim. Pancytopenia is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The aim of this work was to study the etiological spectrum of pancytopenia in the National capital region of India, and evaluate the relationship of pancytopenia with serum vitamin B12 levels. Material and methods. This study is of a prospective and analytical type conducted on patients attending the outpatient and inpatient department of Santosh Medical College and the Saraswathi Institute of Medical Sciences tertiary care centers in NCR. Complete blood counts and peripheral blood smear examination was used for morphological classification and typing of anemia. Bone marrow aspiration and vitamin B12 estimation was performed where required. Results. The maximum number of pancytopenia cases were etiologically attributed to megaloblastic anemia (64.2%) followed by aplastic anemia (19.8%). Malaria was attributed to 6.6% cases of pancytopenia. Iron deficiency anemia and tuberculosis both accounted for 1.9% of cases. each. A history of drug intake and mixed nutritional anemia each contributed to 2.8% of cases. Serum vitamin B12 levels showed a significant relationship with pancytopenic cases. Conclusion. In our study, the main cause of pancytopenia is megaloblastic anemia which responds very well to treatment if diagnosed correctly in time. A detailed hematological assessment along with vitamin B12 levels should be evaluated in all cases of pancytopenia irrespective of the etiological categorization.
An anomalous case report of canine impaction resultant of supernumerary fusion to mandibular incisor
(Publishing Office of the University of Rzeszow, 2024-06) Marushko, Olesya; Kraiz, Aya; Marushko, Olena; Błochowiak, Katarzyna
Introduction and aim. Anomalies in dental characteristics such as size, shape, number, structure, and eruption are commonly observed in clinical conditions. One such anomaly is the presence of supernumerary teeth found in various regions of the dental arch. Although frequently asymptomatic, supernumerary teeth are routinely identified during radiographic evaluations. Among the most common causes of impacted maxillary incisors is the presence of supernumerary teeth. Description of the case. Herein, we present a rare case of lower left canine impaction subsequent to a supernumerary fusion to the mandibular left incisor in a 10-year-old Caucasian female. Conclusion. This case contributes to the current knowledge regarding supernumerary fused teeth, emphasizing the importance of early intervention and multidisciplinary collaboration in effectively managing such developmental dental irregularities.
An overview of incidence and mechanisms promoting weight gain as an adverse effect of oral minoxidil therapy for androgenetic alopecia
(Publishing Office of the University of Rzeszow, 2024-06) Ciulkiewicz, Łukasz; Pełka, Maciej; Fijałkowska, Justyna; Kania, Anna
Introduction and aim. Androgenetic alopecia, with a mechanism based on the excessive response of hair follicles to androgens, affects a majority of people at some point in their lives, prompting them to seek therapy. Current treatment options for this condition include oral minoxidil, a medication associated with an adverse effect of fluid retention, potentially resulting in weight gain for certain individuals. In contemporary scientific literature, there aren’t many articles focusing solely on this specific side effect. The objective of this review is to explore links between taking oral minoxidil and fluid retention leading to weight gain in patients with androgenetic alopecia by examining available studies in order to understand the mechanisms behind this phenomenon and the dose dependence of fluid retention. Material and methods. A review of the literature was performed to find connections between oral minoxidil therapy and water retention-induced weight gain. Analysis of the literature. Clinical trials have demonstrated that low dose oral minoxidil therapy, within the range of 0.5 to 5 mg daily, leads to an improvement in both hair count and density. The incidence of side effects such as hypertrichosis, fluid retention, headache, dizziness, and insomnia, is relatively infrequent. Fluid retention rates varied between 0.22% in the Tanaka study and 10% of patients in the Panchaprateep study. The discontinuation of treatment was necessary in some instances, with the highest rate of 2.4% cases in the Jimenez-Cauhe study. A comparative analysis of studies on oral minoxidil use for refractory hypertension, within the range of 10 to 40 mg daily, revealed that nearly all patients required adding a diuretic to control fluid retention. Some patients discontinued the treatment due to the severity of side effects. In instances of minoxidil overdose, serious complications, including generalized edema, myocardial infarction, stroke, and pleural effusion, were observed. Across these studies, all patients recovered following the discontinuation of minoxidil treatment. The underlying mechanism behind oral minoxidil induced sodium and fluid retention, contributing to weight gain, is associated with alterations in the neurohumoral system, increased plasma renin activity, changes in renal hemodynamics with relocation of the blood circulation from outer to inner cortex, and tubular effect that can be connected to minoxidil ability to act as an opener of potassium channels in the thick ascending limb of the loop of Henle causing greater reabsorption of sodium and chloride. Conclusion. The frequency and severity of water retention promoting weight gain in individuals taking oral minoxidil are dose dependent. In most patients, minoxidil is a safe and effective treatment option for androgenetic alopecia. In some cases, due to rapid weight gain of 5 pounds or more, adding a diuretic or discontinuation may be required. Further research is necessary to better understand the mechanisms and dose dependence of minoxidil induced fluid retention, which promotes weight gain.
Brazilians living with diabetes do not meet basic physical activity guidelines for health – a cross-sectional study
(Publishing Office of the University of Rzeszow, 2024-06) de Lima, Dartel Ferrari; Lima, Lohran Anguera; de Souza, Dayane Cristina; Sampaio, Adelar Aparecido; Machado, Daiana
Introduction and aim. The purpose of this study was to describe the profile of physical activity (PA) of Brazilian adults living with diabetes mellitus living in large Brazilian urban centers, as well as to determine whether the practice aligns with the physical activity guidelines recommended for people with diabetes. Material and methods. Cross-sectional data were acquired from the 2020 Surveillance System for Risk and Protective Factors for Chronic Non-communicable Diseases, in which about 54,000 persons aged 18 and older in all Brazilian state capitals were contacted in a telephone survey. Participants reported on their engagement in recreational physical activity and active commuting to school and/or work in the three months preceding the interview, as well as the weekly frequency and duration of these activities. They also stated whether they were living with diabetes. A descriptive analysis was performed, and statistical significance was determined using Pearson’s chi-squared test. Results. In 2020, 7.9% of the population identified themselves living with diabetes. There was a greater frequency among older women and those with less education. Walking, water aerobics, and general gymnastics were the most common kinds of physical activity reported by people with diabetes. Moreover, over half of them (54.5%) were inactive, and 15% matched the physical activity criteria. The majority (90%) practiced PA for 30 minutes or more per day, while 87% of those who were active and exercised 1 to 2 times per week did not meet the requirements of the Ministry of Health. Conclusion. In 2020, 7.9% of the population identified themselves as having diabetes. There was a higher frequency among older women and those with less schooling. In the sample as a whole, approximately 70% of people living with diabetes were inactive (54.5%) or did not meet the minimum BP recommendations for people with diabetes. The duration of each session seemed to be in line with the recommendations, however, the lack of regularity caused by the low weekly frequency meant that the minimum recommended target could not be achieved. Efforts involving the continued monitoring of people living with diabetes and counseling in Primary Health Care to opt for a more physically active life, seem to be promising acts for a healthier life, pending a definitive resolution to the disease.
Characteristics of patients with cerebral aneurysms and arteriovenous malformations
(Publishing Office of the University of Rzeszow, 2024-06) Ożga, Joanna; Skiba, Marcin; Sztuczka, Szymon; Wyka, Michał
Introduction and aim. Aneurysms and arteriovenous malformations (AVMs) are both vascular abnormalities that can occur simultaneously or separately and increase the risk of intracerebral hemorrhage. The aim of this research was to characterize patients with intracranial aneurysms and AVMs. Material and methods. This retrospective research was based on analysis of Digital Subtraction Angiography. The research group consisted of 118 patients. StatSoft STATISTICA 13 was used for the statistical analysis of parameters, such as dimensions and vascularization pattern of vascular abnormalities. Results. The total number of aneurysms described was 168. In addition, 33 patients with cerebral aneurysms were also diagnosed with cerebral AVMs. The average dimensions of the aneurysms were 6.33mm, 95% CI (5.47 7.18) × 4.76mm, 95% CI (4.09, 5.43). The abnormalities were found in the extent of circulation of ACA (anterior cerebral artery) 50 (29.76%), ICA (internal carotid artery) 48 (28.57%), MCA (middle cerebral artery) 26 (15.48%), PCA (posterior cerebral artery) 23 (13.69%). There were 76 (64%) patients with diagnosed single aneurysms and 42 (36%) with multiple. Conclusion. Aneurysms are more likely to occur singly than multiply. The majority are located within the vascularization of the ACA. Aneurysms can coexist with AVMs, which increases the risk of rupture.
ChatGPT in hospital infection prevention and control – assessing knowledge of an AI model based on a validated questionnaire
(Publishing Office of the University of Rzeszow, 2024-06) Jawanpuria, Ankita; Behera, Aruna Rani; Dash, Chinmaya; Rahman, Mohammad Hifz Ur
Introduction and aim. An AI model like ChatGPT is a good source of knowledge. We can explore the potential of AI models to complement the expertise of healthcare professionals by providing real-time, evidence-based information in infection prevention and control (IPC). Material and methods. This study involved 110 queries related to IPC, validated by subject experts in IPC. The responses from ChatGPT were evaluated using Bloom’s taxonomy by experienced microbiologists. The scores were divided as 4 as a good response. Statistical analysis was done by correlation coefficient and Cohen’s Kappa. Results. The overall score was 4.33 (95% CI, q1 3.65–q3 4.64) indicating ChatGPT’s substantial IPC knowledge. A good response (i.e.>4 score) was found in 70 (63.6%) questions, while in 10 (9%) questions, it showed a poor response. The poor response was seen in needle stick injury and personal protective equipment (PPE) doffing-related questions. The overall correlations were found to be significant. Cohen’s Kappa confirmed moderate to substantial agreement between evaluators. Conclusion. ChatGPT demonstrated a commendable understanding of IPC principles in various domains and the study identifies specific instances where the model may require further refinement especially in critical scenarios such as needlestick injuries and PPE doffing.
Combined non-surgical and surgical management of misdiagnosed cutaneous sinus tract of endodontic origin – 15 months CBCT follow-up
(Publishing Office of the University of Rzeszow, 2024-06) Makkar, Sameer; Rohilla, Smriti; Gupta, Sandeep; Negi, Shabnam; Makkar, Monika
Introduction and aim. An extraoral cutaneous sinus tract of endodontic origin represents a skin condition that appears due to an infection that could be primary or secondary to trauma accompanied by alveolar bony changes. It may be easily misdiagnosed and inappropriately treated due to lack of inadequate expertise on part of medical professionals followed by faulty treatment which can complicate the case further. Description of case. This case report intends to highlight a case of a sixteen-year-old male patient referred for an extraoral cutaneous sinus tract misdiagnosed and insufficiently treated by a general physician followed by general dentists for more than a month due to lack of proficiency in the field of endodontics. The clinical and radiographic examinations confirmed the pulpal origin due to trauma related to permanent mandibular incisors. A combination of non-surgical root canal therapy followed by periapical surgery was performed leading to a significant healing of the lesion. Conclusion. Accurate diagnosis is the key to treat draining sinus tracts of endodontic origin. Root canal treatment and endodontic surgery should be used judiciously for effectively eliminating the pathogens thus providing healing and repair mechanisms a chance to achieve the desired result.
Comparative study of pterygium excision with suture and sutureless conjunctival autograft
(Publishing Office of the University of Rzeszow, 2024-06) Khandelwal, Richa; Tigga, Mary Jenifa; Metri, Rajashekar; Deshpande, Anand; Tarun
Introduction and aim. This is a prospective interventional study to compare corneal astigmatism before and after pterygium excision with conjunctival autograft, to determine the difference in mean corneal curvatures before and after pterygium excision, to evaluate the safety and efficacy of autologous blood technique, and sutured conjunctival autograft for primary pterygium. Material and methods. Patients were divided into group A – pterygium excision+sutured conjunctival limbal autograft and group B – pterygium excision+autologous conjunctival limbal autograft under local anesthesia. The preoperative and post operative K1 and K2 values and BCVA were noted. Results. There was statistically significant reduction in mean astigmatism at each post operative follow up in group A at 1 week (p=0.0249), 2 weeks (p=0.004), 1 month (p=0.0031) and at 3 months (p=0.0009) and similarly in group B post operative follow up at 1 week (p=0.0011), 2 weeks (p=0.0021), 1 month (p=0.0009) and at 3 months (p=0.0003). Conclusion. Pterygium surgery decreases the cylindrical error and reverts corneal curvatures to normal, thus improving subjective visual acuity. Astigmatism produced by the pterygium is reduced after surgery We found autologous conjunctival autograft is superior than sutural conjunctival autograft. Pterygium causes astigmatism depending upon the size of pterygium it should be surgically removed to prevent obstruction in the vision.
Effect of lipopolysaccharide on the development of oxidativenitrosative stress in salivary glands and soft periodontal tissues of rats under conditions of water avoidance stress
(Publishing Office of the University of Rzeszow, 2024-06) Pletnov, Vadym; Tkachenko, Olexiy; Akimov, Oleh; Mykytenko, Andrii
Introduction and aim. Violation in the salivary glands will inevitably cause changes in periodontium, and periodontitis can disrupt the functioning of the salivary glands. The purpose of the work is to evaluate changes in NO-synthase and arginase activities, pro- and antioxidant balance in rat salivary glands and soft periodontal tissues during administration of bacterial lipopolysaccharide (LPS) and water avoidance stress (WAS) modeling. Material and methods. The experiment was performed on 24 rats. The animals were divided into 4 groups: control, WAS, animals injected intraperitoneally with 0.4 μg/kg of bacterial LPS of Salmonella typhi, WAS+LPS. Results. Water avoidance stress led to decrease of inducible NO-synthase (iNOS) activity in salivary glands by 1.63 times, but decreased arginase activity by 1.15 times, superoxide production increased by 1.53 times, catalase activity decreased by 1.2 times, and malonic dialdehyde (MDA) increased by 1.19 times compared to the control. Lipopolysaccharide led to increase of constitutive NO-synthases (cNOS) activity in salivary glands by 1.48 times, but decreased arginase activity by 6.15 times, catalase activity increased by 2.6 times and superoxide dismutase activity decreased by 2.74 times, and MDA increased by 6.84 times compared to the control. Water avoidance stress + LPS in salivary glands led to decrease of cNOS and arginase activity by 1.09 and 1.19 times, respectively, superoxide production increased by 1.88 times, catalase and superoxide dismutase activity decreased by 1.06 times and 1.34 times, respectively, and MDA increased by 2.44 times compared to the control. Water avoidance stress led to increase of iNOS activity in periodontium by 1.44 times and arginase activity decreased by 1.37 times, superoxide production increased 1.32 times, catalase activity and superoxide dismutase activities decreased by 1.27 times and by 1.53 times, respectively, and MDA increased by 1.31 times compared to the control. Lipopolysaccharide led to increase of iNOS activity in the periodontium by 3.88 times, arginase activity decreased by 2.69 times, superoxide production increased 1.64 times, catalase activity increased by 4.32 times, and MDA increased by 4.51 times compared to the control. Water avoidance stress + LPS in periodontium led to increase of iNOS and cNOS activities by 1.95 times and 1.53, respectively, arginase activity decreased by 1.39 times, superoxide production increased 1.66 times, catalase activity increased by 1.11 times, and MDA increased by 1.53 times compared to the control. Conclusion. The combination of LPS and WAS leads to changes in NO production and oxidative stress in salivary glands and the periodontium.
Effectiveness of health education on knowledge, attitude and practice regarding junk food consumption among interns in a tertiary health care center in Chennai, India – a quasi-experimental study
(Publishing Office of the University of Rzeszow, 2024-06) Mary, Bella; Murugan, Arun; Ramasubramanian, Ramachandran; Kamali, Ravinder; Ragavan, Mohanakrishnan Uppili Venkat; Sathishkumar, Kasinathan
Introduction and aim. Junk foods are defined as any of various pre-packaged foods that are high in calories but low in nutritional value. This study was done to evaluate the effect of health education intervention on the knowledge, attitude, and practices regarding junk food consumption among MBBS interns at the tertiary health care center in Chennai, India. Material and methods. This was a quasi-experimental study conducted from January to March 2023 among 105 CRMIs of a Government medical college in Chennai, India. After getting Institutional Ethics Committee approval, data was collected using a pretested self-administered semi structured questionnaire before and after health education intervention. Results. The majority (55.2%) of the respondent interns were hostellers. There was a significant increase in the knowledge (p<0.001), healthy attitude (p<0.001), and healthy practice (p<0.001) concerning junk food intake following health education intervention. Conclusion. Routine repeated sessions promoting health should be implemented in the medical curriculum in order for our future physicians to live a long healthy life as well as to set a good example
Encapsulation of genistein in glycidylated G3 polyamidoamine dendrimers enables diffusion of genistein through biological membranes and anti-nematode activity of the encapsulate
(Publishing Office of the University of Rzeszow, 2024-06) Filipowicz-Rachwał, Aleksandra; Drozdowska, Joanna; Zagórska-Dziok, Martyna; Uram, Łukasz; Wołowiec, Stanisław
Introduction and aim. Poorly soluble isoflavonoid genistein is known as an anti-nematode agent and also it decreases the risk of certain types of cancer. The biological activity of genistein is limited mostly by its low solubility. Therefore many attempts to increase genistein solubility in water were reported. We applied a polyamidoamine dendrimer, modified its surface by glycidylation, and used this macromolecule as a guest for genistein. Material and methods. Polyamidoamine dendrimer 3rd generation was substituted with 64 glycidol residues to obtain a macromolecule host for genistein. The stoichiometry of this host-guest complex was determined. The complex was tested for skin model permeability, toxicity on fibroblast (BJ) and keratinocyte (HaCaT) cell lines in vitro and anthelmintic activity on the Caenorhabditis elegans nematode. Results. The partition coefficient of genistein between octanol and water was determined (KO/W). The 1:1 host-guest complex was isolated and used as drug delivery system for genistein delivery. PAMAM G3 glycidyled dendrimer containing genistein indicated an anthelmintic activity at 50 µM concentration. Conclusion. The solubility of genistein in water increases 640 times in presence of an equimolar concentration of the dendrimer. One molecule of host dendrimer encapsulates 3 molecules of genistein. The encapsulate is an efficient anti-nematode formulation.
Evaluation of primary musculocutaneous Hodgkin’s lymphoma with the aid of 18F FDG PET/CT – a rare entity
(Publishing Office of the University of Rzeszow, 2024-06) Kakkar, Lavish; Singh, Man Mohan; Deswal, Satyawati; Thakur, Priyamedha Bose
Introduction and aim. Primary musculocutaneous lymphoma is extremely rare and associated with poor prognosis. Here, we present a case of refractory primary muscular lymphoma with overlying cutaneous involvement with the aid of 18F-Fluorodeoxyglucose positron emission tomography/computed tomography (18F FDG PET/CT) for staging and treatment. Description of the case. We present the case of a 52-year-old man presented with musculocutaneous Hodgkin’s lymphoma having swelling and discolored areas over the left leg and right arm associated with itchiness. Upon examination, there was scaling, erythema over the body with Gottron’s papules on knuckles and heliotrope rash. Skin and muscle biopsy were suggestive of Hodgkin’s lymphoma. This patient was had primary musculocutaneous lymphoma. His diagnosis was delayed. PET/CT was performed for staging and response to treatment, which was suggestive of refractory disease. Conclusion. PET/CT plays a vital role in diagnosis, staging, response to therapy and helps in optimized treatment for these specific patients.
Evaluation of the knowledge, attitudes and behavior of healthcare workers concerning influenza vaccination in a training and research hospital in Türkiye
(Publishing Office of the University of Rzeszow, 2024-06) Apaydin, Mehmet; Dogan, Serap; Aypak, Cenk
Introduction and aim. Although increasing vaccination rates among healthcare workers (HCWs) is crucial for protecting their own health and preventing the spread of infections to patients, vaccination rates remain low. The purpose of this study is to evaluate the knowledge, attitudes, and behavior of healthcare workers concerning seasonal influenza vaccination in a training and research hospital in Türkiye. Material and methods. This cross-sectional descriptive study was conducted among 364 healthcare workers working in a training and research hospital in Ankara, Türkiye. A face-to-face questionnaire was completed by selected participants that included questions about their sociodemographic characteristics, receiving seasonal influenza vaccination, reasons for not receiving vaccination, attitudes and behavior towards seasonal influenza vaccination recommendations for their surroundings, knowledge of who should get the vaccine, and their immunization history. Results. Among the participants, 58.5% stated that they had never received an influenza vaccination, 35.7% mentioned not receiving the regular influenza vaccination, and only 5.8% reported receiving the influenza vaccination regularly every year. Reasons for not getting vaccinated included not trusting the influenza vaccine’s protection (60.1%), not believing they are in the risk group (38.9%), and not finding a suitable time to get vaccinated (36.1%). A total of 57.1% of the healthcare workers recommended the influenza vaccine for their surroundings. Conclusion. Influenza vaccination rates among healthcare workers are quite low. To maximize influenza vaccine uptake, awareness programs are needed to correct the misconceptions health care workers have about the vaccine, and diverse strategies should be implemented to encourage them to get vaccinated, thereby promoting influenza vaccination.
From diagnosis to recovery – a detailed case report on a nail bed glomus tumor
(Publishing Office of the University of Rzeszow, 2024-06) Shaafie, Harris I.
Introduction and aim. Glomus tumors represent benign neoplastic proliferations of the glomus body, an integral thermoregulatory component within the cutaneous microvasculature. Although they can manifest at various anatomical sites, they are predominantly observed in the subungual region. The tumors present as painful, firm, purplish, solitary nodules of the extremities, especially in the nail bed. They may be solitary or multiple; solitary lesions are encapsulated and most commonly subungual, while multiple tumors are unencapsulated and rarely subungual. Description of the case. Here, we present a case of multiple glomus tumors of the right hand in an 18-year-old female who presented with complaints of painful bluish discoloration of the right little finger for six years and progressive asymptomatic nodules on the right index finger for six months. A clinical examination revealed acute tenderness in both fingers. Love’s pin test and Hildreth’s test were positive. Excision of all lesions was done and sent for histopathology, which confirmed the diagnosis. The patient was symptom-free immediately following surgery. No nail deformities were noticed, and there was no recurrence of symptoms after one year of follow-up. Conclusion. The transungual approach is a safe and effective minimally invasive surgical technique for the treatment of symptomatic nail bed glomus tumors. It offers high success rates, promising cosmetic outcomes, and minimal complications. However, careful patient selection and meticulous surgical technique are essential to avoid potential nail deformities.
Genetic factors contributing to the development of inguinal hernias – a narrative review
(Publishing Office of the University of Rzeszow, 2024-06) Kalali, Datis
Introduction and aim. Inguinal hernias are one of the major disorders in the field of general and visceral surgery and can be viewed as multifactorial diseases. Although the molecular mechanism that led to predistortion to inguinal herniation still remain unclear, is well known that defects leading to improper closure of the inguinal canal during fetal development and mechanisms contributing to weaker muscles of the abdominal wall can greatly increase the risk of developing the latter disease. Material and methods. A literature search was performed in all major electronic databases using keywords and Boolean operators to retrieve all available literature related to the topic. Due to the narrative nature of the review, there were no specific inclusion and exclusion criteria. Analysis of the literature. Genetic factors, undoubtedly, can interfere with these mechanisms and therefore play major role in developing hernias. To this end, the present narrative review provides an overview of genes with altered expression and genetic polymorphisms associated with inguinal herniation. Moreover, the results of genome-wide association studies (GWAS) exploring susceptible genetic loci associated with the disease have been reported. Conclusion. Nevertheless, more case-control studies and GWAS need to be conducted in different ethnic populations so as to provide better insights into the topic.
Gifted children and their peers perceived parental attitudes, psychosocial problems and quality of life
(Publishing Office of the University of Rzeszow, 2024-06) Yildiz, Sümeyye; Altay, Naime
Introduction and aim. Gifted children are defined as extraordinary children due to their high level of intelligence and specific skills. This study aimed to examine gifted children and their peers perceived parental attitudes, quality of life (QoL), and psychosocial problems. Material and methods. The study sample consisted of two groups: (1) gifted children (study group) and their parents and (2) peers (control group) and their parents. Data were collected using a descriptive characteristics form, the parental attitude scale (PAS), the pictorial pediatric symptom checklist (PPSC) and the pediatric quality of life inventory (PedsQL). Results. Both groups were similar in terms of age, gender and grade level. It was mostly the mothers who completed the data collection forms. The study and control groups had a mean PAS score of 94.18±0.738 and 99.31±0.798, respectively and a mean PPSC score of 16.11±0.475 and 16.76±0.480, respectively. The study and control groups had a mean QLS score of 83.19±0.70 and 80.28±0.83, respectively. There was a weak positive correlation between the PAS and PPSC scores (r=0.92; p<0.166). Conclusion. It is recommended that parental attitudes and their effects on children’s psychosocial status and QoL be monitored and that parents be supported. Parental attitudes and a child’s psychosocial and behavioral problems and QoL levels should be assessed to by health professionals be able to improve the well-being of both children and their parents.
Inference of oxidative stress in patients with hypothyroidism
(Publishing Office of the University of Rzeszow, 2024-06) Rada, Feryal
Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.
Knowledge of esophageal cancer and preventive behaviors among nursing students – a cross-sectional study
(Publishing Office of the University of Rzeszow, 2024-06) Cevik, Ayfer Bayindir; Andsoy, Işıl Işık; Yıldız, Hicran
Introduction and aim. There is a gap in nursing student understanding, knowledge, and preventive behaviors concerning esophageal cancer. This study aimed to investigate knowledge, risk factors, and preventive behaviors among Turkish nursing students. Material and methods. A descriptive cross-sectional survey was performed. The questionnaire was conducted online over a four-month period. A convenience sample of 688 undergraduate nursing students was recruited from health science faculty at three universities in Türkiye. The survey was performed using a self-administered questionnaire. The reliability coefficients of the knowledge test were calculated, yielding Cronbach’s alpha (0.952), KR-20 (0.952), and KR-21 (0.945), respectively. A significance level p<0.05 was accepted. Results. The mean age of the study group was 20±1.86 (min: 17, max: 32). The study group consists of 487 women (70.8%) and 201 men (29.2%). Most of the study population report never using alcohol and smoking (88.4%, 73.1%, respectively), and reported paying attention to oral hygiene (88.5%). Nursing students had a low family history of EC (0.4%), obesity (10.2%), and vitamin deficiency (19.2%) which are risk factors. Knowledge of esophageal cancer risks was low (x̄=14.34±9.53; Min=0; Max=31). Total knowledge scores have higher for students with complaints of EC, vitamin deficiency, and diagnosis of Human Papilloma Virus disease (p<0.05). Conclusion. This study showed that there are significant gaps in the knowledge of nursing students and these need to be addressed through an improved nursing curriculum. In this context, the study can be used as important evidence and a resource in the issues that should be given priority to in the training and research needed to increase the knowledge and awareness of future nurses about esophageal cancer.
Novaluron and indoxacarb induced methemoglobinemia – unveiling a rare poisoning
(Publishing Office of the University of Rzeszow, 2024-06) Shaji, Ijas Muhammed; Mohanty, Chitta Ranjan; Radhakrishnan, Rakesh Vadakkethil; Siddique, Ruby Nahan
Introduction and aim. In India, the utilization of agricultural pesticides for intentional self-poisoning is a prevalent method, and it is associated with substantially higher fatality rates compared to other self-poisoning approaches. Plethora, an agricultural insecticide containing novaluron (5.25%) and indoxacarb (4.5%), has recently been introduced and widely used in India and various other regions for its broad-spectrum lepidopteran control. While there have been documented cases of isolated self-poisoning involving indoxacarb, there is currently no literature reporting incidents of human poisoning specifically related to novaluron. Description of the case. An 83-Year-old male was presented to the emergency department (ED) with a history of consumption of 50 mL of an insecticide suspension concentrate called ‘PLETHORA’ to commit suicide. He had one episode of vomiting and dizziness after the ingestion. There was associated cyanosis, and the patient was put on high-flow oxygen at 10 L/min through a face mask. The patient was diagnosed to have methemoglobinemia and was successfully treated with methylene blue and ascorbic acid. One hour post methylene blue injection showed a methemoglobin level of 1%, and the patient gradually improved. Patients presenting with novaluron and indoxacarb poisoning require supportive treatment as there is no specific antidote. There should be a high index of suspicion for methemoglobinemia in such patients, and timely management is necessary to prevent further complications. The patient was successfully managed and discharged after the 3rd day of admission. Conclusion. The management of patients with novaluron and indoxacarb poisoning primarily involves supportive care, as there is currently no specific antidote available for these substances. Maintaining a high suspicion index for the development of methemoglobinemia and timely management of other complications is crucial for the best possible patient outcomes.

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Przeglądanie European Journal of Clinical and Experimental Medicine T.22, z. 2 (2024) według Tytuł