European Journal of Clinical and Experimental Medicine T.17, z. 4 (2019)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/5174

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A new local therapy of periodontitis in the course of stomach pathology and tobacco smoke intoxication
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Romanova, Iuliia; Zolotukhina, Olena; Shnaider, Stanislav; Kravchenko, Lyudmila; Noneva, Nataliia
Introduction. Inflammatory periodontal diseases, arising against a background of stomach pathology from tobacco addiction remain an acute problem of modern dentistry. Aim. The experimental assessment of a new local treatment efficiency during therapy of simulated periodontitis with hyperacid gastritis and the tobacco smoke intoxication. Material and methods. The work was conducted in 2 stages. At the first stage, all experimental animals were divided into 4 groups: І — intact, II — with simulated periodontitis, III — with simulated periodontitis and hyperacid gastritis, IV — with simulated periodontitis with hyperacid gastritis and tobacco smoking. The local therapy efficiency was evaluated with the use of a new preparation for oral care and a comparison product conducted at the 2nd stage in rats with simulated periodontitis with hyperacid gastritis and tobacco smoking. Results. Experimental periodontitis with hyperacid gastritis and tobacco smoking provokes considerable changes in the periodontal tissues typical for the inflammatory process: lipid peroxidation activity rises and antioxidant system activity reduces. A local therapy in rats resulted in correction of detected metabolic disorders, improving removal of the damaging factors harmful influence and restoring the periodontal tissues condition. Conclusion. The medical efficiency of a new gel normalizes the influence of lipid peroxidation processes, inflammation and the oral cavity protective system activation during periodontitis which arises up against a background of the concomitant pathology of stomach – hyperacid gastritis.
An experimental analysis of different point specific musculoskeletal pain among selected adolescent-club cricketers in Dhaka City
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Rashaduzzaman, Mohammad; Kamrujjaman, Mohammad; Islam, Mohammad Ariful; Ahmed, Sharmin; Al Azad, Salauddin
Introduction. Musculoskeletal disorders (MSDs) are considered to be among the most stressful events of human body considering their onset, symptoms and the ultimate consequences. Aim. This study was conducted to provide a concise overview of cricket-related musculoskeletal pain of the upper limb and lower limb region in male adolescent cricketers. Material and methods. Data was collected from three clubs in Dhaka city, and the participant’s age group was 10–19 years. Data was collected through oral conversations with participants and physical testing. This process was continued over six months, which repeated monthly between same subjects. Results. 97 cricketers experienced musculoskeletal pain, where maximum reported upper limb musculoskeletal pain was 33.3% shoulder, 21.6% elbow, 27.5% wrist, and 17.6% hand pain. In contrast, 46 candidates were found in the lower limb musculoskeletal pain category containing 19.6%, 30.4%, 30.4% and 19.6% hip joint, knee joint, ankle joint and foot joint musculoskeletal pain, respectively. BMI had no significant effect on the typical upper and lower limb musculoskeletal pain. Batsmen playing for 4 sessions or more per week are the main victims of upper limb musculoskeletal pain. In contrast, bowlers and all-rounders were the main victims of lower limb musculoskeletal pain under similar workloads. Conclusion. This study reflects an up-to-date overview of regional upper limb and lower limb musculoskeletal pain where the risk of lower limb injury is most common among all types of players.
Applicability of Cardiopulmonary Exercise Test
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Wołoszyn, Filip; Pańczyszyn-Trzewik, Patrycja; Ziajor, Seweryn; Misygar, Aleksandra; Bednarski, Artur; Kwiatkowski, Oskar; Sowa-Kućma, Magdalena
Introduction. Cardiopulmonary Exercise Testing (CPET) test is a test that allows an integrated response to the physical effort of the cardiovascular system, respiratory system, nervous system, skeletal muscles and metabolism. The growing awareness of better correlation between health condition and exercise tolerance than with resting measurements is the key importance. The range of clinical applications is expanding to assess impairment of physical capacity with an unclear cause and to objectively determine functional capacity. Aim. The aim of this review was to discuss the applicability of cardiopulmonary exercise test in diverse branches of clinical and non-clinical use. Material and methods. This review was performed according to latest literature. We mainly searched PubMed and Google Scholar to look for previous cases of CPET applicability. Results. CPET has a very wide range of applications for the diagnosis of physical productivity as seen through athletes and amateurs in their own right. This medical diagnostic practice allows us to map out the inconsistencies the blood, respiratory and bone systems/structures. Conclusion. Cardiopulmonary exercise test is a safe method of different disease assessment. It can be use in various cases, to rate reaction of an organism to physical effort.
Clinical application of monoclonal antibodies in targeted therapy
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Superson, Maciej; Szmyt, Katarzyna; Szymańska, Katarzyna; Walczak, Kamil; Wnorowski, Jeremi; Zarębski, Łukasz
Introduction. Recently, monoclonal antibodies (mAbs) have become powerful human therapeutics in the diagnosis and treatment of many diseases. Drugs based on mAbs are approved for the treatment of cardiovascular, respiratory, hematology, autoimmunology, and oncology diseases. Aim. To present the current state of knowledge about the application of mAbs in the therapy of various diseases such as cancer, autoimmune and Alzheimer’s diseases. Material and methods. We conducted a thorough review of the scientific literature from the following databases: EBSCO, PubMed, Science Direct, and Springer Link. Results. Currently, the Food and Drug Administration (FDA) has approved more than 50 therapeutic mAbs which are applied in various clinical trials. Action of mAb are based on various mechanisms, including directly targeting the cells, modifying the host response, recognizing and degrading molecules as well as delivering cytotoxic moieties. Conclusion. Despite some limitations including side effects, and therapeutic challenges, monoclonal antibodies are an attractive option for the development of new therapies and molecular drug targets against a wide range of common diseases due to their specificity and flexibility. MAbs are considered as a great hope for medicine, and effective and safe drugs in the treatment of various diseases.
Current recommendations for treatment and diagnosing of xerostomia in Sjögren’s syndrome
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Zablotskyy, Oleh; Tomczyk, Martyna; Błochowiak, Katarzyna
Introduction. Xerostomia is one of the most common and disturbing adverse effects of systemic diseases and their therapies. This complication markedly increases the risk for dental caries, difficulties with chewing, swallowing and sleep disorders with a significant impact on the patient’s quality of life. Sjögren’s syndrome (SS) is a systemic autoimmune disease that primarily affects the exocrine glands, resulting in dryness of the mouth due to lymphocytic infiltration of the salivary glands. Aim. The aim of this paper is to present the current recommendations in diagnosing and treating SS-related xerostomia. Material and methods. Analysis of literature Results. For the assessment of SS-related xerostomia, only an unstimulated salivary flow with rates of 0.1 mL/min is included in the current SS classification criteria. Saxon test, sialography, ultrasonography of salivary glands play supporting function. Treatment of SS -related xerostomia includes an application of secretagogues and the implementation of specific dental prophylaxis measures. Adjuvant therapies include herbal remedies, photobiomodulation, and acupuncture. Conclusion. Treatment of SS requires multidisciplinary care. There is no fully effective treatment of xerostomia that provides immediate and long-lasting results.
Difficulties in diagnosis of carcinoma of the tongue
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Panda, Dwijesh Kumar
Introduction. Oral cancer is the second most common malignancy and there is an epidemic alert by WHO for oral cancers projected for 2030. The tongue remains the most common intraoral site for oral cancer worldwide. Aim. To present a case report. Description of the case. A 56-year-old patient was suffering from carcinoma of the tongue. He developed metastases in the lungs and upper part of the vertebral column. The PET scan report revealed the presence of hypermetabolic cells in the metastatic tissue. The biopsy of the lesion on the upper part of the back did not show neoplastic cells, epithelioid cells and giant cells. Radiotherapy was given for 25 cycles. Both the lungs were affected by metastases. Lastly the patient expired due to cardio- respiratory failure. Conclusion. Tobacco is the most important known risk factor for the development of tongue cancer. The tumors in their early stage with complete excisional treatment have good prognosis. There is usually a history of long standing leukoplakia or erythroplakia. Ideally, imaging should take place prior to biopsy. Surgical procedures such as hemiglossectomy can cause functional defects in speech and swallowing. Difficulty in diagnosis results in inappropriate treatment.
Granular cell tumor of the neurohypophysis – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Dziedzic, Rafał; Leksa, Natalia; Aebisher, David; Bartusik-Aebisher, Dorota
Introduction. The granulomatous tumor (GCT) is formed from the posterior pituitary (neurohypophysis) or its pedicle. The location of such a tumor in the region of the Turkish or supra saddle is a very rare matter. Aim. To present a case report. Description of the case. This article describes the case of a 39-year-old man admitted to the Department of Neurosurgery with a MR-diagnosed head tumor in the suprasellar area growing out of the pituitary funnel. The tumor appeared to be an epileptic fit. Conclusion. Herein we described a clinical case of granulomatous tumor. GCTs in the pituitary nerves are benign tumors, which makes treatment dependent on the individual case. After the operation, the H-P study showed a granulomatous tumor (GCT) of the posterior pituitary gland.
Imaging studies of kidney cancer
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Przyczyna, Piotr; Aebisher, David; Gustalik, Joanna; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Kaznowska, Ewa
Introduction. In 2017 in the USA about 5% in men and 3% in women newly diagnosed cases of malignant tumors were kidney and renal pelvis cancer. Aim. Kidney cancer in adults includes malignant tumors derived from kidney parenchyma and renal pelvis. The dominating types are kidney parenchyma, and mainly renal cell carcinomas Material and methods. This review was performed according to systematic literature search of three major bibliographic databases (Scopus, PubMed, and Cochran). Results. Imaging studies play a very important role in kidney cancer. They allow one to assess the clinical stage, justify the extent of surgery and have an impact on the prognosis. Conclusion. The field for research involves the use of magnetic resonance and positron emission tomography in diagnosing kidney changes.
Laparoscopic partial cystectomy for bladder endometriosis – case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Godlewski, Dominik; Pszczółkowski, Patryk; Góra, Tomasz; Futyma, Łukasz; Fedus, Tadeusz; Aebisher, David
Introduction. Endometriosis is defined as a presence of endometrial glands and stroma outside the uterus. Urinary track endometriosis is a rare occurrence (1-2%) usually associated with bladder involvement (85%). Aim. The diagnostic evaluation is not complicated but can be delay because of the lack of specific symptoms. Description of the case. We present a case of 20-years old female with bladder endometriosis localized on the posterior wall. The patient was effective treated with laparoscopic partial cystectomy Conclusion. The patient was effective treated with laparoscopic partial cystectomy.
Morphology of extensor digitorum longus of Wistar rats after remobilization by vibratory platform
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Camilo, Izabela Rodrigues; Wutzke, Maria Luiza Serradourada; Costa, Rose Meire; Bertolini, Gladson Ricardo Flor; Ribeiro, Lucinéia de Fátima Chasko
Introduction. In exercise, vibrations are performed in order to produce rapid and short changes in muscle length. These changes are detected by sensory receptors, in response try to dampen the vibratory waves through a modulation of muscle stiffness. However, its effects on the morphology of muscle tissue are still not fully established, especially after long periods of immobilization. Aim. To compare the effects of the vibratory platform on the remobilization of the extensor digitorum longus (EDL) muscle of Wistar rats with free remobilization. Material and methods. 20 rats were divided into: CG (Control), IG (immobilized), IFG (immobilization and free remobilization), IPG (immobilization and remobilization with vibratory platform). The immobilization was performed on the pelvic limb for 15 days. The remobilization with vibratory platform was done for 10 minutes daily, for 2 weeks. The EDL was processed for histological analysis of cross-sections. Results. The area, larger diameter, smaller diameter and fiber density of the EDL muscle of GI presented significant alteration when opposed to CG, IFG and IPG. The density of nuclei of the EDL muscle of IG presented a significant increase when opposed to the others, and IPG also presented a significant increase when compared to CG. Conclusion. The morphology and morphometry of the EDL muscle tissue were affected, and both free and vibration platform remobilization re-established the morphological aspects of the muscle fiber, without significant differences between the methods.
Multiparametric MRI and other imaging methods suitable to stage prostate carcinoma
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Osuchowski, Michał; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Kaznowska, Ewa
Introduction. The role of multiparametric magnetic resonance imaging (mpMRI) in staging prostate carcinoma has been increasing over the last years. It’s high sensitivity is indispensable when diagnosing this disease. It is a very accurate imaging method that helps the physician choose the best treatment method for his patient. Aim. Assessment of mpMRI which uses both anatomic and functional imaging techniques as a method to diagnose prostatic lesions. Advantages and disadvantages of staging prostate carcinoma with the use of biparametric MRI (bpMRI). Methods. The literature search was performed. Results. MpMRI can be used in pre-operative staging of prostate cancer. The technique is accurate in diagnosing and assessment of prostate carcinoma with Gleason Score (GS) of 7 and above. It is also recommended when planning a second biopsy of the prostatic gland.
Osmotic demyelination syndrome in a patient with slowly equalized severe hyponatremia – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Rudnicka-Czerwiec, Julia; Bartosik-Psujek, Halina
Introduction. Osmotic demyelination syndrome (ODS), or central pontine myelinolysis (CPM), is a complication of severe and prolonged hyponatremia, particularly when hyponatremia is corrected too rapidly. However, even slow correction of hyponatremia can result in ODS. Aim. In this paper, we describe a patient who developed ODS following slow correction of hyponatremia. Description of the case. This article describes a case of chronic hyponatremia occurring in the course of alcoholism. The patient was admitted in severe condition with extremely low sodium level. Electrolyte supplementation was carried out according to the European Renal Best Practice (ERBP) guidelines; however, there was a rapid increase in sodium level leading to the development of symptomatic osmotic demyelinating syndrome. Following several weeks of rehabilitation and supplementation of B vitamins, the patient’s condition gradually improved. Conclusion. Sodium deficiency should be equilibrated very carefully, especially in patients with chronic hyponatremia in the course of alcoholism. Even small doses of sodium administered in accordance with the guidelines in chronic hyponatremia can cause a rapid increase in serum sodium level resulting in osmotic demyelination syndrome.
Pelvic Exenteration: An Updated Mini-Review from 1948 to 2020
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Unal, Ethem; Yıldız, Abdullah; Yuksekdag, Sema; Fırat, Aysun
Introduction. Pelvic exenteration (PE) is a curative or palliative radical surgical procedure applied for advanced or recurrent pelvic or perineal cancers. From 1948 to date, improvements in surgical techniques, including urinary conduits and pelvic reconstruction, have improved its morbidity and mortality. Aim. The present study reviews the evolution of PE, indications, complications and current results. Material and methods. Large case series and studies on PE were searched in PubMed, covering all years available, and recent applications of PE were reviewed. Results. Indications of PE are primary or locally advanced tumors (cervix. rectum. vulva. bladder), recurrence after radiotherapy (cervix), recurrence after primary resection (vulva, vagina, cervix, rectum) and palliative treatment for advanced tumors or pubic fistulas. Contraindication are distant metastases, involvement of iliac vessels, pelvic side-wall or para-aortic lymph nodes and invasion of sacrum proximal to S1/S2 or sciatic foramen. However, recent studies have reported more radical resections, including side-wall and vessels. Patient’s health condition and fitness are also important in decision-making. Conclusion. PE can be the last chance of cure or improving quality of life for advanced or locally recurrent pelvic cancers. 5-year survival rates with PE are better, but complications of such a radical surgery are still high, and should be improved.
Prevalence of depression in Indian patients with type 2 diabetes mellitus and/or hypertension: DEPTH Study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Lalwani, Raj Kumar; Shah, Jayesh Dashrathlal; Chatterjea, Tapas; Nadakuduru, Papa Rao; Erande, Suhas
Introduction. Depression, a common psychiatric mood disorder, is a leading cause of disability and a significant contributor to the overall global burden of disease. Aim. To determine the prevalence of depression in patients with controlled and uncontrolled type-2 diabetes mellitus (T2DM) and/or hypertension (HTN) in India. The association of depression with socio-demographic profile and clinical risk factors was also assessed. Material and methods. In this cross-sectional epidemiological study, T2DM and/or HTN patients attending outpatient department at tertiary care hospitals and private clinics across 54 cities in India were enrolled. The primary outcome measure was to determine the prevalence of depression in T2DM, HTN and T2DM + HTN patients. Association of depression with patients’ demography, socio-economic status, anxiety, and clinically diagnosed insomnia were also investigated. Results. Of 1829 patients, the prevalence of depression in T2DM, HTN and T2DM+HTN cases were found to be 51.03%, 46.94% and 48.64%, respectively. A higher proportion of patients with uncontrolled T2DM and HTN reported depression (T2DM: 77.64% vs. 22.36%; HTN: 72.49% vs. 27.51%). There was a significant association between anxiety and severity of depression across all indications (p<0.0001). Depression was significantly associated with complications in T2DM (p=0.0001) and comorbidities in T2DM + HTN (p=0.0023) cases. Conclusion. Depression is highly prevalent and has a direct significant association with various socio-demographic variables and anxiety in Indian patients with T2DM and/or HTN.
Rating of the effectiveness of cleaning and disinfection procedures in a mass catering establishment
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Sidor, Adam; Preizner, Patrycja
Introduction. An increasing problem in maintaining the proper level of hygiene in food industry plants is microbiological hazards, affecting the quality and safety of produced food, which in consequence may lead to the creation of many negative health effects on consumers. Aim. Determination of the degree of microbiological contamination of machinery and equipment as well as small production equipment before the commencement of production activities and rating of the effectiveness of the implemented procedures of cleaning and disinfection in a mass catering establishment. Material and methods. The research material was the surfaces of machinery and equipment as well as small production equipment used in a mass catering establishment located in the Primary School in Przemyśl. Microbiological tests were carried out using the swab method in accordance with the recommendations of the Polish Standard PN-A-82055-19: 2000. Results. The hygienic condition of the marked surfaces largely differed from the specific hygiene standards described in PN-A- 82055-19: 2000. In most cases the degree of microbial contamination was insufficient. It is recommended to follow strictly defined washing and disinfection procedures every time after finishing work and if necessary before proceeding with production. Conclusion. The obtained results showed that there was secondary microbiological contamination of the determined production areas subjected to cleaning and disinfection. It was found that the procedures of cleaning and disinfection of small production equipment, including parts of machines and devices, were properly developed, while there are discrepancies in their implementation.
Serosurvey and Cellular Immune Status of HTLV-1/2 and HIV Co-infections in Bauchi State, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Babayo, Adamu; Azeez Akande, Oyebanji; Sabo, Yusuf Mohammed; Abdullahi, Idris Nasir; Dangana, Amos
Introduction. Human T-cell lymphotropic virus types 1 and 2 (HTLV-1 & 2) are frequent co-pathogens among immunosuppressed individuals, particularly HIV/AIDS infected persons. Dual infected persons usually present with false normal or high CD4+ T cells count as a result of the ability of HTLV to induce clonal proliferation of CD4+ T lymphocytes. There is paucity of information on this clinical entity in Nigeria. Aim. This study aimed to determine the seroprevalence of HTLV-1/2 and associated cellular immune response among antiretroviral naďve and experienced HIV infected persons at Bauchi State, Nigeria. Material and methods. One hundred and eighty two (182) HIV seropositive patients’ blood samples were analyzed for anti HTLV-1/2 IgM and IgG antibodies using ELISA while CD4+ T cells were counted using Flow cytometry technique. Socio-demographic data of the subjects and clinical history were obtained via questionnaire and medical records, respectively. Results. The seroprevalence of anti-HTLV-1/2 was 14%. This comprised 76 (41.8%) males and 106 (58.2%) females. Six (3%) were seropositive for both ant-HTLV -1&2 IgM and IgG. Of the total positive for anti-HTLV-1/2, 20 (25%) ART-naďve and 6(5.9%) ART-experience subjects. Whole blood CD4+ T cell count was significantly high in HTLV-1/-2 IgG/IgM seropositive subjects compared to their HTLV-1/-2 negative counterpart. Conclusion. All subjects (100%) who were HTLV-1/-2/HIV co-infected had normal to higher CD4+ T cell counts. It is suggested to be very careful in using only CD4+ counts to monitor HIV progression or as indicators for ART.

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