European Journal of Clinical and Experimental Medicine T.22, z. 4 (2024)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/11151

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A rare case of hypertrophic olivary degeneration in a patient with pontine hemorrhage
(Publishing Office of the University of Rzeszow, 2024-12) Mamytova, Elmira; Biialieva, Gulmira; Akulich, Evgeniya; Abaeva, Tamara; Monolov, Nurbek; Satybaldiev, Masalbek; Chekirbaeva, Nursulu; Batyrov, Maksatbek
Introduction and aim. Hypertrophic olivary degeneration (HOD) is an extremely rare disease that affects the inferior olivary nucleus (ION) in the medulla oblongata and is also referred to as hypertrophic degeneration of the inferior olives. This type of degeneration is characterized by trans-synaptic degeneration resulting from the blocking of afferent impulses in the ION, which is distinct from HOD. In this report, we present a clinical case of bilateral HOD that was identified and confirmed by neuroimaging two months after pontine hemorrhage. Description of the case. A 52-year-old male was admitted to a university hospital because of gait imbalance, difficulty in swallowing and speaking, psychomotor agitation, visual hallucinations, and full vertical and horizontal gaze paralysis. He had a history of hypertension, hyperlipidemia, and obesity. The patient received symptomatic supportive treatment, without surgery. Ten weeks after the vascular incident, neurological examination revealed six cases of right cranial nerve palsy, vertical pendular nystagmus, dysarthria, decreased throat reflexes, and lingual and pharyngeal paresthesia. Repeated magnetic resonance imaging revealed bilateral hyperintense foci of 15×6 mm in the medulla oblongata, as detected by T2-weighted and fluid-attenuated inversion recovery. Two months of treatment with clonazepam, carbamazepine, and vestibular exercise resulted in no positive changes. Rehabilitation and psychotherapy were then continued. Conclusion. Contrast MRI is required to confirm HOD, whereas non-contrast magnetic resonance imaging is the only method used for imaging and is not always reliable because it can cause neoplasia, infarction, demyelinating disorders, infections, and other similar problems.
Assessment of behavior and barriers of post-exposure prophylaxis for prevention of rabies in patients attending a tertiary care center in eastern India – a mixed method approach
(Publishing Office of the University of Rzeszow, 2024-12) Debata, Ipsita; Nayak, Rosy; Behera, Basanta Kumar; Panda, Prem Sagar; Nayak, Smrutiranjan; Mandal, Dibyajyoti
Introduction and aim. Rabies from animal bites, although preventable, is almost 100% fatal, with the dog being the most common infected animal. Several factors influence the timely initiation of post-exposure prophylaxis (PEP) which needs to be explored. This study aimed to determine the facilitating and inhibiting factors in initiating PEP among animal bite victims attending a tertiary care center in Eastern India. Material and methods. A cross-sectional study was conducted among 150 consenting animal bite victims attending casualty and medicine as out-patients in a tertiary care hospital. A mixed-method study approach was undertaken to explore the facilitating and inhibiting factors for the timely initiation of PEP using a pre-tested and semi-structured questionnaire and in-depth interviews. Data were analyzed using SPSS software version 20. Results. The most common biting animal were dogs (96.2%). Around 102 patients (68%) were males and 48 (32%) were females. Timely initiation of PEP was seen in 112 (74.7%) of the study sample while delay was seen in 38 (25.3%). The inhibiting factors were the absence of an accompanying person (54.67%), the absence of vaccines and immunoglobulins in the nearest health facility (50.67%), referral from other health facilities (44%) and preferred other modalities of treatment (24.67%). Delays in initiation of PEP was significantly associated with gender (p=0.018), place of residence (p<0.001), those living more than 20 km from a health facility (p=0.014), educational status (p<0.001), and those with monthly income <10000 INR (p<0.01). Conclusion. Lower economic status, education, and accessibility to health facilities were major inhibiting factors causing a delay in the initiation of PEP. Further, community-based studies are warranted.
Assessment of the quality of life in type 2 diabetes patients – a comparative study of WHOQOL-BREF and DQOL instruments
(Publishing Office of the University of Rzeszow, 2024-12) Asti, Arnika Dwi; Sarwono; Kinwati; Suwaryo, Putra Agina Widyaswara
Introduction and aim. Type 2 diabetes mellitus (T2DM) is a prevalent health issue that significantly impacts the quality of life of patients. Evaluating quality of life in T2DM patients is crucial for understanding the broader effects of the disease and improving patient care. This study aims to evaluate and compare the effectiveness of the WHOQOL-BREF and DQOL instruments in measuring the quality of life of T2DM patients. Material and methods. A descriptive quantitative study was conducted from March to June 2023 at Puskesmas Wanadadi 1 Banjarnegara. The sample consisted of 195 T2DM patients selected using purposive sampling based on the following inclusion criteria: diagnosed with T2DM for at least one year, aged 30-70 years, willing to participate, and able to complete the questionnaires. Data were collected using the WHOQOL-BREF and DQOL questionnaires and analyzed descriptively. Results. The analysis revealed that the WHOQOL-BREF and DQOL instruments provided comprehensive insights into the quality of life of T2DM patients. The WHOQOL-BREF was particularly effective in assessing physical and environmental domains (p<0.05), while the DQOL was more sensitive to diabetes-specific concerns and psychological well-being (p<0.05). Conclusion. Both the WHOQOL-BREF and DQOL are effective in evaluating the quality of life of T2DM patients, each offering unique strengths in different domains. The findings suggest that a combined use of these instruments could provide a more holistic understanding of the quality of life impacts in T2DM patients, guiding more targeted interventions to improve patient outcomes.
Comparison of novel bioactive, bioceramic materials in vital pulp therapy in deciduous teeth – a clinical in vivo study
(Publishing Office of the University of Rzeszow, 2024-12) Acharya, Sonu; Gurunathan, Deepa
Introduction and aim. The use of modern bioceramic materials has enhanced the predictability of vital pulp therapy. This study aimed to assess the clinical success of Biodentine, modified NeoPutty mineral trioxide aggregate (MTA), and calcium hydroxide Ca(OH)2 as pulp capping materials for indirect pulp capping in carious primary teeth. Material and methods. Indirect pulp treatment (IPT) was performed on 36 deciduous molars in 36 patients who were presented with deep carious lesions. The teeth were randomly assigned to three groups: Biodentine (12 teeth), modified NeoPuttyMTA (12 teeth), and Ca(OH)2 (12 teeth). Results. A statistical analysis was conducted using SPSS software version 21.0. Pearson’s Chi-square test was employed to compare success and failure rates among Biodentine, modified Neoputty MTA, and Ca(OH)2 at three different time intervals (30, 90, and 180 days) and overall success and failure rates regardless of the time intervals. In the statistical analysis, different pulp capping materials yielded varying success rates. The modified NeoPutty MTA group demonstrated a success rate of 91.67%, the Biodentine group 83.33%, and the Ca(OH)2 group 58.33% after 6 months. However, these differences were not statistically significant. Conclusion. IPT with calcium silicate-based materials, such as Biodentine and modified NeoPutty MTA, showed superior results when compared to the use of calcium hydroxide Ca(OH)2. Although differences in success rates were observed among the materials, they did not reach statistical significance.
Composite index of anthropometric failure and conventional anthropometric indices of undernutrition among children in India – a systematic review and meta-analysis
(Publishing Office of the University of Rzeszow, 2024-12) Roy, Soumyajit Singha; Mondal, Nitish
Introduction and aim. The high prevalence of childhood undernutrition continues to be a major public health issue in India. This systematic and meta-analysis study employed both the composite index of anthropometric failures (CIAF) and conventional to determine the magnitude of undernutrition in Indian children. Material and methods. A comprehensive literature search was conducted from 2005 to June 2023 using electronic databases, including Google Scholar, Web of Science, SCOPUS, PubMed, J-Gate, and ScienceDirect. A random-effects model for pooled prevalence rates was generated and heterogeneity was assessed using the I2 index and Q statistics. Analysis of the literature. CIAF revealed a higher prevalence of undernutrition than conventional anthropometric indices in children aged 0 to 72 months. The combined prevalence of stunting and underweight was 37% (95%CI: 0.32-0.41), and wasting was 22% (95%CI: 0.18-0.25) (p<0.01). However, according to CIAF categorization, the pooled prevalence of undernourishment was reported to be 55% (95% CI:0.50-0.60; p<0.01). CIAF’s higher prevalence highlights its effectiveness in capturing childhood undernutrition, accounting for children with multiple concurrent nutritional deficiencies in population. Conclusion. This systematic review and meta-analysis investigated the assessment of undernutrition using conventional anthropometric indices compared with CIAF, which aggregate different aspects of undernutrition, especially when children have multiple undernutrition issues. Appropriate, target-specific interventions are necessary to improve the overall nutritional status of Indian children.
Congenital epulis in a newborn – a case report in Benin City, Nigeria
(Publishing Office of the University of Rzeszow, 2024-12) Oriaifo, Sylvester; Eweka, Osasere Andrew; Atoe, Kenneth
Introduction and aim. Congenital epulis is a rare benign tumor that affects the oral cavity of newborns which typically presents as a solitary mass on the maxillary alveolar bridge at birth, with a predilection for the female gender. The rarity of congenital epulis is underscored by the limited number of reported cases in the literature, as evidenced by the infrequent occurrence of this condition in newborns. Description of the case. This case report presents a rare case of congenital epulis, a benign gingival tumor in a newborn. The report includes a brief literature review to provide insights into the clinical characteristics, diagnostic approaches, and management of congenital epulis. Conclusion. This case contributes to the current knowledge regarding rarity of occurrence and emphasizes the need for reporting, early intervention and multidisciplinary collaboration in effective management.
Cryptogenic stroke in a young patient after COVID-19 infection – a case report
(Publishing Office of the University of Rzeszow, 2024-12) Liyanage, L.R. Sathisha Deshan; Purvishbhai, Soni Karsh; Antipina, Ekaterina Olegovna
Introduction and aim. Cryptogenic stroke (CS) is a type of cerebral ischemia in which the cause is unknown or unclear. It can be difficult to determine the cause of CS because of various factors, such as incomplete investigations or the transient or reversible nature of the event. Infections can increase the risk of stroke by causing localized inflammation of the meninges and cerebral parenchyma, systemic inflammation, coagulation, and endothelial dysfunction. COVID-19-related cerebrovascular events can happen due to a hypercoagulable state from systemic inflammation and cytokine storm, post-infectious immune-mediated responses, and direct viral-induced endothelitis, which can lead to angiopathic thrombosis. Description of the case. A 25-year-old male was diagnosed with mild semantic aphasia. The patient had a history of moderate COVID-19 infection. An angiography revealed that the M2 segment of the middle cerebral artery in the left hemisphere was not contrasted, indicating an occlusion. MRI and CT scans showed evidence of ischemic changes in the left hemisphere of the brain. The patient was treated with several drugs, including antiplatelet and neuroprotective drugs. Conclusion. Our case demonstrates that autoimmune antibody formation, specifically antinuclear antibodies, can cause vasculopathy, leading to thrombus formation and stroke. It suggests a potential link between autoimmune antibody formation and stroke in COVID-19 patients.
Determination of the effect of gender perception among university students on attitudes towards disabled women
(Publishing Office of the University of Rzeszow, 2024-12) Ünal, Esra; Öztürk, Simge
Introduction and aim. This study investigates the effect of gender perception among university students on attitudes towards disabled women. Material and methods. The target population of this descriptive and cross-sectional study consisted of university students enrolled in the Faculty of Health Sciences in a province located in southern Türkiye. The Socio-demographic Form, the Gender Perception Scale, and the Attitudes towards Disabled Women Scale were administered to the participants through Google Forms. The sample of the study consisted of 644 students registered at the Faculty of Health Sciences and meeting the inclusion criteria. Results. A positive and moderately significant correlation was found between gender perception and attitudes towards disabled women among students who were enrolled in the Faculty of Health Sciences. The variables explaining 26.3% of the total variance for the attitudes towards disabled women included the presence of a disabled individual in the family, education of disabled individuals together with individuals with no disabilities, views about the marriage of disabled women, kinship with the disabled relative, and gender perception scale score. Conclusion. It was concluded that gender perception had a significant effect on the attitudes of students enrolled in the Faculty of Health Sciences towards disabled women.
Determining treatment success in tubal ectopic pregnancies – the predictive value of the delta neutrophil index in single-dose methotrexate therapy
(Publishing Office of the University of Rzeszow, 2024-12) Korpe, Busra; Kose, Caner; Celen, Sevki; Kucukbas, Gokce Naz; Ustun, Yaprak Engin
Introduction and aim. This study assessed the significance of the Delta neutrophil index (DNI) in predicting the effectiveness of single-dose methotrexate (MTX) treatment for tubal ectopic pregnancy. Material and methods. In this retrospective study, 214 women diagnosed with tubal ectopic pregnancies and treated with MTX between 2019 and 2022 were included. Group 1 comprised 88 MTX responders, while group 2 consisted of 86 non-re sponders necessitating surgery. HCG and DNI levels were monitored on day 1, 4, and 7 of MTX treatment and compared be tween the groups. Results. Group 1 exhibited significantly lower HCG and DNI levels compared to group 2 on days 1, 4, and 7 (p<0.001). Both HCG and DNI levels on days 1 and 4 of MTX treatment were significant predictors of treatment failure, with the highest AUC observed for DNI was on day 4. In multivariate logistic regression analysis, elevated DNI levels on day 1 of MTX treatment were associated with a 5.8-fold increased risk, and DNI levels on day 4 were associated with a 4.44-fold increased risk of MTX treatment failure. Conclusion. DNI emerges as a valuable marker for predicting the success of single-dose methotrexate treatment in tubal ecto pic pregnancies, demonstrating superior predictive power compared to HCG.
Doctoral dissertations in nursing – research protocols in a multicenter comparative study
(Publishing Office of the University of Rzeszow, 2024-12) Teixeira-Santos, Luísa; Cerveny, Martin; Collins, Daniela; Nagórska, Małgorzata; Patel, Harshida; Shao, Joy; Sihvola, Saija; Simoes, Angela; Warshawski, Sigalit; Luiking, Marie-Louise
Introduction and aim. Nursing doctoral research is vital for advancing the field, improving patient care, and addressing complex healthcare challenges. It contributes to evidence-based practices, innovative interventions, and the development of skilled nurse researchers and leaders, shaping the future of healthcare through enhanced knowledge and informed policy decisions. This scoping review aims to map the landscape of PhD dissertations in the nursing domain. Inclusion criteria: This scoping review will consider doctoral studies in nursing domain published in Dutch, English, Finnish, Hebrew, Portuguese, Polish, Slovak, Swedish, published between 2020–2023. Material and methods. The search strategy was to find published literature in the following electronic databases: CINHAL, PubMed, SCOPUS, PsycINFO, Web of Science, Psychology & Behavioral Sciences Collection, and ERIC. Additionally, national repositories of several countries was explored, and contact established with universities represented by the members of this research team. The screening process entailed two steps carried out by two independent reviewers: firstly, screening by title and abstract and secondarily by full text. Data describes the literature according to the review research questions that were defined following the PPC mnemonic. Data will be presented graphically when possible and accompanied by a narrative that describes the Ph.D. dissertation characteristics. Conclusion. Identifying areas of research in nursing contributes to the development of nursing as a science.
Effect of sensory retraining program on latency, amplitude and conduction velocity of sensory nerves of lower limb in type 2 diabetic peripheral neuropathy
(Publishing Office of the University of Rzeszow, 2024-12) Maruboyina, Sowjanya; Attry, Sanjeev; Kumari, B. Kusuma; Reddy, K. Eswar; Perakam, Sravanthi
Introduction and aim. India is known as the world’s diabetes capital. Diabetic neuropathy is the most common complication of diabetes, and if not managed properly, leads to diabetic foot complications like ulcers and amputations. Physiotherapy interventions addressing these complications are very limited. Hence, this study was performed to access to what extent a sensory retraining program affects the latency, amplitude, and conduction velocity of the sural nerve in lower limbs. The study aims to improve the nerve conduction velocity of the sural nerve in diabetic neuropathy with a sensory retraining program. Material and methods. One-hundred individuals who met the inclusion criteria were randomly allocated into 2 groups. The control group had received routine medical care. The experimental group individuals were managed with a sensory retraining program 5 days a week for 16 weeks. Latency, amplitude, and conduction velocity values were recorded before and after the study. Results. Results conclude that the sensory retraining program is effective in decreasing the latency and improving conduction velocity. It did not have any effect on the amplitude. Conclusion. Hence, we conclude that a sensory retraining program can be incorporated into routine physical therapy intervention in subjects with diabetic peripheral neuropathy.
Effects of vitamin D3 supplementation on lipid profile and renal indices in rat model of drug induced renal injury
(Publishing Office of the University of Rzeszow, 2024-12) Sonuga, Ayobola A.; Adeyanju, Motunrayo M.; Ladokun, Olusola A.; Sonuga, Oyebola O.
Introduction and aim. Renal injury is associated with decreased renal function, hypovitaminosis D, deranged calcium-phos phate metabolism and dyslipidemia, thus increasing risk for chronic kidney disease and cardiovascular diseases. However, re ports on the effects of vitamin D on drug induced renal injury are few. The aim was to investigate the possible role of vitamin D supplementation in reversing deranged lipid profile and renal function post drug induced renal injury. Material and methods. Wister male rats (36) were randomly divided into group 1, 2 and 3 (n=12). Single dose of Adriamycin was given to all except group 1(control) to induce renal injury. Group 2 left untreated, group 3 given vitamin D3 for 28 days. Serum urea, creatinine, total protein, total cholesterol (TC), triglycerides (TG), LDL-C, HDL, apolipoprotein (Apo) A and B were measured. C-reactive protein (CRP) and nitric oxide were assessed in kidney homogenate. Results. Vitamin D3 significantly brought down levels of serum creatinine, TC, LDL CRP, nitric oxide and increased the levels of Apo A, albumin, HDL. Serum urea, TG and Apo B in group 3 were not significantly different after vitamin D3 administration. His tological examination revealed improvement in glomerular messangialisation. Conclusion. Vitamin D3 may improve renal health, through its positive impact on dyslipidemia, inflammation, and oxidative stress in drug induced renal injury.
Forensic aspects of salbutamol overdose – doping, abuse, and suicide
(Publishing Office of the University of Rzeszow, 2024-12) Kycler, Maciej; Rzepczyk, Szymon; Teżyk, Artur; Żaba, Czesław
Introduction and aim. Salbutamol is a popular drug used in respiratory diseases. With the increasing prevalence of the use of this substance for therapeutic purposes and its availability on the market, the frequency of its use for other purposes has also risen due to its effects outside the respiratory system. The aim of the study was to investigate the medico-legal aspects of salbutamol. Material and methods. Medical literature databases such as PubMed, Scopus, Web of Science and Google Scholar were searched. The search was carried out in accordance with the specified purpose of the keyword research using Boolean operators. Analysis of the literature. In sports, the use of salbutamol is strictly regulated by anti-doping regulations. Recreational substance abuse and accidental overdoses, mainly among children and the elderly, are also important. Rare cases of suicide attempts associated with the use of salbutamol have also been reported. Conclusion. Salbutamol overdoses are usually not life threatening. However, one should remember about the possibility of accidental overdose, especially among the elderly and children taking the drug chronically. Currently, the use of salbutamol for recreational purposes is rare. In sports, the status of salbutamol use, especially among athletes who do not require its use for therapeutic reasons, is still a controversial issue.
Growth differentiation factor 15 – a review of current literature on biological roles and clinical significance
(Publishing Office of the University of Rzeszow, 2024-12) Rzemieniewski, Bartosz; Kasztelan, Aleksandra; Poboży, Kamil; Domańska-Poboża, Julia
Introduction and aim. Growth differentiation factor 15 (GDF15), a member of the TGF-β superfamily, plays crucial roles in various physiological and pathological processes including inflammation, apoptosis, angiogenesis, cell repair, growth, metabolic regulation, and immune response. This review aims to discuss the biological roles and clinical significance of GDF15 and to analyze its impact across different medical fields such as cardiology, oncology, neurology, gynecology, and areas related to aging and metabolic disorders. Material and methods. A review was constructed through a literature search on PubMed and Google Scholar databases, focusing on studies from 2014 to 2024, using relevant keywords. Analysis of the literature. Recent research highlights GDF15’s potential as a biomarker in cardiovascular diseases, its role in cancer progression and resistance to therapies, and its significance in metabolic regulation affecting conditions like obesity, diabetes, and cachexia. Emerging research also points to its role in aging, mitochondrial diseases, and systemic conditions such as sepsis, liver, and lung disorders. Conclusion. GDF15’s involvement in multiple pathological states and its broad impact across various medical disciplines underline its potential for future clinical applications. Understanding GDF15’s complex roles could lead to novel therapeutic strategies and enhance prognostic assessments in diverse medical fields.
Improving sleep quality among ICCU patients – evaluating the effectiveness of ear plug and eye mask interventions
(Publishing Office of the University of Rzeszow, 2024-12) Waladani, Barkah; Utami, Wuri; Ernawati; Suwaryo, Putra Agina Widyaswara
Introduction and aim. Sleep quality is crucial for patient recovery, particularly in critical care settings such as the Intensive Cardiac Care Unit (ICCU). This study aimed to investigate the effectiveness of using eye masks and earplugs in improving sleep quality among ICCU patients. Material and methods. A quasi-experimental study was conducted using a one-group without control design. A total of 40 ICCU patients were provided with eye masks and earplugs for a minimum duration of three days. Sleep quality was assessed using the Richard Campbell Sleep Questionnaire (RSCQ) before and after the intervention. Data were analyzed using descriptive and inferential statistics. Results. The use of eye masks and earplugs significantly improved sleep quality among ICCU patients (p<0.05). There was a notable increase in sleep duration, reduction in sleep onset latency, and improvement in sleep efficiency following the intervention. These findings support the efficacy of non-pharmacological interventions in enhancing sleep quality in critical care settings. Conclusion. The findings highlight the importance of incorporating simple interventions such as eye masks and earplugs into routine care practices in ICCUs to improve patients’ sleep quality.
Low depression scores among pet dog owners – a comparative cross-sectional study from Anuradhapura Sri Lanka
(Publishing Office of the University of Rzeszow, 2024-12) Rathish, Devarajan; Rajapakse, Jayanthe; Weerakoon, Kosala
Introduction and aim. The role of canine companionship in psychosocial and cardiovascular health is increasingly explored. However, such studies are scarce in South Asia. Hence, we aim to compare psychosocial and cardiovascular indices between pet dog owners and age and sex-matched non-pet owners in Anuradhapura, Sri Lanka. Material and methods. A community-based, comparative, cross-sectional study was done among 52 pet dog owners and 52 age, sex-matched non-pet owners. An allostatic load was calculated using predefined cutoffs. Chi-square (or Fisher’s exact), Mann Whitney U, and Spearman’s rho were performed (p<0.05). Results. The pet dog owners’ group had a significantly lower mean (SD) [7.8 (7.2)], and median (interquartile range) [6 (2–12.5)] depression score when compared to the non-pet owners [11.2 (8.6)], 10 (6–14.5) respectively (p=0.03). Also, the pet dog owners showed a significant negative correlation between the pet bond scale score and cortisol (r=-0.36, p=0.01). Conclusion. A significantly lower depression score in the pet dog owners’ group than in the non-pet owners’ group was observed. And, the pet bond score had a significant negative correlation with the stress hormone cortisol. Thus, pet dog ownership could improve psychosocial health and will guide towards one-health interventions and research among South Asian communities.
Morphometric analysis of dry acetabulum and iliac bones from anatomy museums in south eastern Nigeria with relation to clinical practice
(Publishing Office of the University of Rzeszow, 2024-12) Ekwedigwe, Henry Chinedum; Esom, Emmanuel; Katchy, Amechi Uchenna; Anyaehie, Udo Ego; Ozor, Ignatius Ikem; Ekwunife, Remigius Tochukwu; Aniagu, Chikaodi Victoria
Introduction and aim. Good outcomes of total hip replacement and acetabular surgeries have been linked to proper understanding of the morphometry of acetabular and iliac bones. The aim of this study was to analyze the clinical morphometry of dry acetabulum and iliac bones in southeastern Nigeria. Material and methods. The measurements were done on human hip bones in anatomy museums using a Vernier caliper. The acetabular and iliac bone parts were measured. Results. A total of 148 dry hip bones were measured during the study. The mean acetabular depth and diameter are 32.10±2.33 mm, and 53.93±2.74 mm respectively. The mean thicknesses of the acetabular walls are 5.88±1.38 mm, 12.64±1.84 mm, 15.79±2.07 mm and 19.74±2.18 mm for the antero-inferior, antero-superior, postero-inferior and postero-superior walls respectively. The distances between landmarks on the iliac bone are: anterior-inferior-iliac-spine – posterior-inferior-iliac-spine = 112.91±8.01 mm, posterior-superior-iliac-spine – anterior-inferior-iliac-spine = 135.29±8.04 mm, anterior-inferior-iliac-spine – anterior-superior-iliac-spine = 34.98±9.55 mm, posterior-superior-iliac-spine – upper-edge-of-acetabulum = 119.14±7.83 mm and anterior-superior-iliac-spine – nearest-edge-of-acetabulum = 55.71±5.60 mm. The regression model for prediction of diameter of the acetabulum using the depth of the acetabulum shows that for every 1 mm increase in the acetabular depth, the acetabular diameter increases by 0.312 times. The regression equation is “Y = bx + a”; Y = acetabular diameter, x = acetabular depth, b = margin of error = 0.312, and a = constant determined to be 43.919. Conclusion. The study established the mean values and the relationship between acetabular depth and diameter.
Neonatal lupus in an infant with maternal history of Jessner’s lymphocytic infiltrate
(Publishing Office of the University of Rzeszow, 2024-12) Katakam, Bhumesh Kumar; Dhabal, Arunima; Gurram, Narsimha Rao Netha; Chintagunta, Sudharani
Introduction and aim. Neonatal lupus erythematosus (NLE) is a rare autoimmune condition occurring in infants born to mothers with circulating antinuclear autoantibodies, particularly anti-Ro and anti-La. It presents with a characteristic cutaneous rash, which may be accompanied by systemic manifestations. The condition is mostly self-limited, although congenital heart block, if present, is irreversible. We report a rare case of cutaneous NLE in an infant of a mother with a prior history of Jessner’s lymphocytic infiltration of skin (JLIS), which is arguably a variant of cutaneous lupus erythematosus (LE). Description of the case. This report concerns an infant presenting with cutaneous manifestations of NLE, without any systemic involvement. The mother was asymptomatic, but had been previously diagnosed with JLIS. The diagnosis of NLE was made based on serological results from both the infantile and maternal blood. Conservative management was sufficient to achieve complete resolution. Conclusion. The case underscores the importance of considering NLE in infants presenting with annular rash, even in asymptomatic mothers with no known rheumatic disease. It also suggests that JLIS may belong to the same spectrum as LE, rather than being a separate entity. This warrants careful prenatal monitoring in mothers with a concurrent or prior diagnosis of JLIS.
Perceived COVID-19 anxiety, fear and depression levels among university students during the decreased restrictions of COVID-19 pandemic
(Publishing Office of the University of Rzeszow, 2024-12) Baş, Kazim
Introduction and aim. The COVID-19 pandemic has negatively impacted human life. It is observed that a significant group affected by this situation are university students. Evaluating the psychological states of students during the transition to normal life from the pandemic period is important. This study was conducted to examine the perceived levels of COVID-19 anxiety, fear, and depression among university students during the descreased restrictions of the COVID-19 pandemic. Material and methods. This cross-sectional study was conducted with 1170 university students. The data were collected using “the Introductory Information Form, the Fear of COVID-19 Scale, the Coronavirus Anxiety Scale – Short Form, and the Depression Scale. Results. It was observed that there was a difference between gender, class, education level, income level, having had COVID-19, and having a deceased relative due to COVID-19 and perceived COVID-19 anxiety and fear and depression levels among university students (p<0.05). Conclusion. During the COVID-19 pandemic, although restrictions have been lifted, students still experience moderate levels of COVID-19 anxiety, fear, and depression. Therefore, considering the factors that affect university students’ mental state, there is a need for services that support students’ mental well-being.
Phytochemical analysis, stability, and antimicrobial activity of eighteen medicinal plants studied against five multi-drug resistant human pathogens
(Publishing Office of the University of Rzeszow, 2024-12) Malya, G. Dharshana; Bhattacharjee, Jhumpa; Mukherjee, Sahana; Deka, Shubhajyoti; Saikia, Lahari; Nandi, Shoma Paul
Introduction and aim. Several medicinal plants from India have been reported to be effective against human pathogens, but comprehensive comparative studies are scarce. The aim of this study has been to evaluate and compare the antimicrobial activity, phytochemical composition, and stability at different temperatures and pH of ethanolic extracts of eighteen Indian medicinal plants which are prevalent in North-east India and thrive abundantly. Material and methods. These plants included Syzygium cumini, Cannabis sativa, Camellia sinensis, Murraya koenigii, Alstonia scholaris, Terminalia chebula, Flemingia strobilifera, Azadirachta indica, Prunus persica, Euphorbia thymifolia, Averrhoa carambola, Paderia foetida, Psidium guajava, Spondias pinnata, Garcinia cowa, Litsea cubeba, Micania macrantha, and Phlogocanthus thyrsiflorus. Their potent medicinal properties made them the ideal choice for this study which included the use of agar well diffusion method and phytochemical analysis. Results. Agar well diffusion has been used to test their antibacterial activity, which demonstrated higher antibacterial activity of G. cowa extract against Vibrio cholerae and Staphylococcus aureus, whereas S. pinnata extract was most effective against V. cholerae and Enterococcus faecium. Conclusion. Phytochemical analysis revealed the presence of tannins, alkaloids, saponins, glycosides, steroids, terpenoids, flavonoids, and phenols. The antimicrobial activity of these plant extracts remained stable at higher temperatures and varying pH levels.

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Przeglądanie European Journal of Clinical and Experimental Medicine T.22, z. 4 (2024) według Tytuł