Przeglądanie według Temat "wound healing"

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A promising approach to wound healing – in-vivo study of carbon nanodots infused PVA hydrogel with Kamias extract as antibacterial wound dressing
(Publishing Office of the University of Rzeszow, 2023-06) Hipolito, Marilene C.
Introduction and aim. The use of carbon nanodots (C-nanodots) synthesized from Kamias leaves for developing antibacterial wound dressings has gained attention due to their potential in promoting wound healing and contraction. To extract Kamias leaves, synthesize C-nanodots through microwave-assisted pyrolysis, characterize the synthesized C-nanodots, and test the polyvinyl alcohol (PVA) hydrogel infused with C-nanodots for antibacterial activity and wound contraction in Sprague Dawley rats. Material and methods. Kamias leaves extract was used to synthesize C-nanodots with varying amounts of monoethanolamine. The C-nanodots were characterized using UV-Vis spectrophotometer, electron microscope, and the paper disk method. The PVA hydrogel infused with C-nanodots was tested for antibacterial activity and wound contraction in Sprague Dawley rats. Results. The synthesized C-nanodots exhibited antibacterial properties against Staphylococcus aureus and Subtilis bacillus, with a zone of inhibition ranging from 15 mm to 23.6 mm at different concentrations. The carbon nanodots-PVA hydrogel patch showed potential wound healing ability, with significant differences in wound contraction compared to the positive and negative controls. Conclusion. C-nanodots synthesized from Kamias extract have potential applications in antibacterial and wound healing fields. However, further studies are required to investigate the mechanism of action and potential side effects of using carbon nanodots in these applications.
Wound healing potential of Apamarga Ksharodaka (herbal alkaline water made from Achyranthus aspera Linn.) in excision rodent wound model
(Rzeszów University Press, 2025-03) Garg, Ayush Kumar; Rai, Sachchida Nand; Prajapati, Chandrabhan; Mishra, Shashank Shekhar; Singh, Santosh Kumar; Sen, Binay
Introduction and aim. Wound healing is a biological process that aims to restore tissue integrity and function. Despite medical advances, wound management remains challenging. Traditional medicinal preparations, like Apamarga ksharodaka (AK), offer promising therapeutic potential due to their phytochemical richness. This study evaluated wound healing and antimicrobial activity of AK. This study aimed to validate the traditional claim of AK’s wound healing potential using an excision wound model. Material and methods. An excision wound model was created using 24 male Wistar rats. A positive control group applied 5% w/w povidone-iodine (PI) ointment. Wound contraction (WC), epithelialization period (ET), wound closure day, and histopathology were assessed. Antibacterial activity was evaluated against Escherichia coli, Streptococcus aureus, Pseudomonas aeruginosa, and Acinetobacter baumannii. Results. AK showed slightly better wound healing than PI ointment, with significant results in WC rate, wound closure, and ET. Histopathology revealed normal skin and organ architecture. The minimum MIC was 6.25 mg/ml against Pseudomonas aeruginosa with a maximum inhibition zone of 15 mm. Conclusion. AK is safe and effective for wound healing.