Przeglądanie według Temat "subclinical hypothyroidism"

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Comparison of triglyceride-glucose index and HOMA-IR as indicators of insulin resistance in obese women with subclinical hypothyroidism
(Publishing Office of the University of Rzeszow, 2022-12) Kirac, Cem Onur; Sirikci, Vehbi; Findikli, Huseyin Avni
Introduction and aim. Thyroid hormones play an important role in glucose metabolism as in many metabolic events. The aim of our study is to evaluate the relationship between subclinical hypothyroidism (SCH) and insulin resistance, especially in obese women. Material and methods. Newly diagnosed SCH patients with body mass index (BMI) ≥30 who applied to our outpatient clinic between March 2021 and October 2021, and euthyroid obese women who applied for routine control were included in the study. In this study, we used homeostasis model assessment of insulin resistance (HOMA-IR) and triglyceride glucose (TyG) indexes, which are noninvasive, simple and useful methods for evaluating insulin sensitivity. Results. The study included 78 female patients between the ages of 19 and 64. A correlational analysis was performed between thyroid stimulating hormone (TSH) and HOMA-IR, TyG, and BMI. The results showed that TSH levels were positively correlated with HOMA-IR (R=0.297, p=0.008), TyG (R=0.316, p=0.005) and BMI (R=0.307, p=0.006). This relationship was stronger for TyG compared to the other variables. As another finding, BMI was positively correlated with HOMA-IR (R=0.359, p=0.001) and TyG (R=0.404, p<0.001). This relationship was stronger for TyG than HOMA-IR. Conclusion. These results show that patients with SCH are at risk of developing diseases that accompany insulin resistance, such as metabolic syndrome and cardiovascular disorders. The most important finding of our study is that the TyG index gives more significant results than HOMA-IR, especially in obese women.
Spatial working memory in hypothyroidism – an observational study on different ranges of thyroid stimulating hormone
(Rzeszów University Press, 2025-03) Jhandi, Satkarjit Kaur; Shenoy, Shweta; Singh, A. P.; Singh, Ajaypal
Introduction and aim. Hypothyroidism is associated with cognitive impairments. Clinically, subclinical hypothyroidism (SCH) is very common and patients often experience symptoms such as forgetfulness or memory deficits. Despite achieving normal thyroid stimulating hormone (TSH) levels through levothyroxine (LT-4) treatment, patients still report persistent complaints of lack of memory. Previous imaging studies have shown abnormalities in some cognitive domains, particularly in spatial working memory (SWM), that are characteristic of SCH. Therefore, the current study aimed to investigate SWM function across different ranges of TSH in patients with SCH. Material and methods. This cross-sectional study included a total of 136 participants. Group 1: 36 controls, group 2: 33 newly diagnosed patients with SCH (TSH levels ≥2.5 mIU/L), group 3: 32 patients with SCH (elevated TSH levels ≥4.0 mIU/L) having L-T4 treatment, group 4: 35 euthyroid (TSH levels <4.0 mIU/L) but ongoing LT-4 treatment. The SWM task was performed for an assessment of SWM function, using a computerized battery (Cambridge Neuropsychological Test Automated Battery-CANTAB). Results. Our results report a statistically significant difference in the key parameters of SWM task among all groups. Conclusion. Our findings indicate that patients with SCH show better performance in SWM when their TSH levels decrease with LT-4 treatment, in comparison to patients who were newly diagnosed. The present study suggests a TSH level of 2.5 mIU/L may be the optimal threshold for initiating LT-4 treatment in patients with SCH.