Przeglądanie według Temat "rheumatoid arthritis"

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A study of several hematological and immunological parameters of patients with rheumatoid arthritis and their relationship with type 2 diabetes mellitus
(Rzeszów University Press, 2025-06) Abed, Gadder Osama; Ali, Baida Rihan
Introduction and aim. Rheumatoid arthritis (RA) is a systemic inflammation that damages the joints and causes disability. In RA, glucocorticoids reduce inflammation and peripheral insulin resistance. This study aimed to investigate hematological and immunological parameters, including interleukin-24 (IL-24), interleukin-32 (IL-32), and rheumatoid factor (RF), in patients with RA, type 2 diabetes mellitus, or both, and to assess their interrelationships. Material and methods. A case-control study on RA and type 2 diabetes mellitus was conducted at Al-Nasiriyah Education Hospital with 100 blood samples collected from patients, divided into four groups. Complete blood counts (CBC), erythrocyte sedimentation rate (ESR), RF, IL-24, and IL-32 levels were measured using automated analyzers and enzyme-linked immunosorbent assay. Results. Patients with both diseases showed elevated ESR (p<0.001) and RF (p<0.01). RA patients increased significantly in ESR and RF, but there was no statistically significant difference in RF in type 2 diabetic patients. IL-24 was not statistically significantly increased in RA patients. IL-32 levels increased significantly in type 2 diabetes (p=0.02), while RA showed no significant difference. Conclusion. Patients with RA have elevated levels of IL-32 expression and has a positive correlation with indicators of RA activity indicators such as ESR and RF. An increase in IL-24 and IL-32 in RA patients indicates a positive correlation between IL-24 and IL-32. Diabetic patients exhibit significantly elevated pro-inflammatory properties of IL-32.
Association between body mass and physical activity with quality of life in patients with rheumatoid arthritis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2017) Świtała, Anna; Wyszyńska, Justyna; Czerwińska, Kinga; Dereń, Katarzyna; Podgórska-Bednarz, Justyna; Guzik, Agnieszka
Introduction. Rheumatoid arthritis (RA) is a progressive joint condition that leads to joints destruction and complications in the internal organs and significantly affects the a patient’s functional, physical, psychological and social condition. Over the last few years, research into the quality of life (QoL) in people with chronic disease has been conducted to assess the results of treatment. Aim. The aim of the study was to assess QoL in various areas of life in regards to physical and mental functioning, social relations, and environmental influences in people with RA. Material and methods. The study group (subjects with RA) and the control group (subjects without RA) consisted of 48 people each. Subject age ranged from 19 to 68. In order to assess QoL, the WHOQOL-BREF questionnaire was used, while socio-demographic data were assessed with a questionnaire developed by the authors. Results. QoL in people with RA was lower than that of healthy individuals. The worst QoL was observed in the physical domain. No statistically significant association was found between BMI and QoL. It was found, however, that subjects with RA and a higher level of physical activity had a better QoL than those with a lower level of physical activity. Conclusion. There was no association between the body mass of RA patients and QoL assessment. However, an association was found between the level of physical activity in people with RA and QoL in the physical and environmental domain.
Autoimmune diseases and their various manifestations in the oral cavity – a systematic review
(Publishing Office of the University of Rzeszow, 2023) Lin, Shin-Yi; Huang, Yu-Wei; Błochowiak, Katarzyna
Introduction and aim. Oral manifestation of the disorder is the leading cause of common initial features of most autoimmune diseases. Therefore, this study aimed to present different oral manifestations of selected autoimmune diseases. Material and methods. We systematically reviewed the etiology, signs and symptoms, oral manifestations, epidemiology, diagnosis, treatment plan, and prognosis. We searched the articles on PubMed, Google Scholar and Web of Science for the following search term: Behcet’s disease, lichen planus, mucous membrane pemphigoid and bullous pemphigoid, pemphigus vulgarisms and paraneoplastic pemphigus, rheumatoid arthritis, Sjögren’s syndrome, IgG4-related disease, systemic lupus erythematous, and granulomatosis with polyangitis. Analysis of the literature. We conducted that the disorder’s oral manifestation causes most autoimmune illnesses’ earliest symptoms. Conclusion. Clinical-pathological is a piece of requisite knowledge for the dentist to recognize and diagnose in the early phase of the symptoms.
Correlation between rheumatoid arthritis and periodontitis
(Publishing Office of the University of Rzeszow, 2022-12) Zielińska, Anna; Tabarkiewicz, Jacek
Introduction and aim. The association between periodontitis (PD) and rheumatoid arthritis (RA) has been analyzed and described in literature. Periodontal pathogens, such as “Porphyromonas gingivalis” and “Aggregatibacter actinomycetemcomitans” are pointed as the common factors for both diseases. In this work we demonstrate that treatment of dental and oral diseases is an unconditional requirement for patients with RA. Material and methods. PubMed was searched with the keyword “rheumatoid arthritis” and “periodontitis” from May 1999 to January 2022, showed 181 articles. Ultimately 72 articles were included in the review. Analysis of the literature. The above mentioned pathogens exhibit multiple mechanisms that disturb immune and inflammatory responses of the human organism. Those mechanisms lead to the periodontal disease (PD) that may activate the systematic reactions which in turn lead to intensification of systematic diseases such as rheumatoid arthritis (RA). P. gingivalis has the ability to expresses PAD enzyme (peptidylarginine deiminase) and activates the citrullization process. Moreover, the bacterium produces gingipain cysteine proteinases, which degrade the mechanisms of immunological system. The latter pathogen, A. actinomycetemcomitans, expresses hypercitrullization in neutrophils. Conclusion. Both pathogens influence inflammatory response of the organism, through the common pro-inflammatory mediators for periodontitis and rheumatoid arthritis, intensify the clinical manifestations of both diseases.
Ocena metylacji DNA i polimorfizmów wybranych genów oraz ekspresji wyselekcjonowanych mikro-RNA u chorych na reumatoidalne zapalenie stawów
(Uniwersytet Rzeszowski, 2019-12-12) Cieśla, Marek
WSTĘP: Reumatoidalne zapalenie stawów (RZS) jest chorobą o podłożu autoimmunologicznym dotyczącą około 1% populacji globalnej. Czynnik V regulowany interferonem (IRF5) jest czynnikiem transkrypcyjnym, biorącym udział w ostrych i przewlekłych odpowiedziach immunologicznych. Supresor III sygnalizacji cytokin (SOCS3) oraz receptor dla interleukiny 6 (IL6R) są zaangażowane w szlak sygnałowy interleukiny 6 (IL-6), która odgrywa ważną rolę w patogenezie RZS-u. CEL: Celem pracy było oznaczenie markerów molekularnych dla RZS-u i ich związku z nasileniem choroby. MATERIAŁY I METODY: Do badania włączono 122 pacjentów z RZS-em, z których 82 było RF-pozytywnych, a 40 RF-negatywnych, oraz 24 zdrowe kontrole. Wśród pacjentów z RZS-em wybrano 32 o wysokiej aktywności choroby oraz 22 w remisji, jak również zdrową kontrolę, którzy zostali włączeni do analizy metylacji DNA i ekspresji miR-ów WYNIKI: Dla genu IRF5 pacjenci RZS wykazali o 43,6% niższy stopień metylacji w stosunku do grupy kontrolnej. Nie wykazano różnic w metylacji dla genów SOCS3 oraz IL6R. Pacjenci RF-ujemni wykazali wyższą frekwencję w polimorfizmach IRF5 rs4728142 oraz SOCS3 rs4969168, przy czym zależało to od zastosowanego modelu genetycznego. Ekspresja miR-22 była wyższa o około 62% w grupie pacjentów z RZS-em w stosunku do grupy kontrolnej. WNIOSKI: Zmiany w metylacji IRF5 we krwi obwodowej oraz ekspresja miR-22 w osoczu mogę stanowić potencjalne markery RZS-u.
Selegiline modulates inflammatory indicators in RAW 264.7 macrophages and LPS-aggravated CFA-induced rheumatoid arthritis in rats
(Publishing Office of the University of Rzeszow, 2024-03) Ahmed, Abdul Baquee; Chetia, Purbajit
Introduction and aim. Rheumatoid arthritis (RA) causes pain, inflammation, and deformities in numerous joints. Monoamine oxidase B (MOA-B) inhibitor selegiline exhibits anti-inflammatory characteristics and has the propensity to scavenge free rad icals. Therefore, the aim of this research comprises of assessing the effect of selegiline on proinflammatory cytokines in RAW 264.7 macrophages as well as its capacity to improve various arthritic parameters in rats with lipopolysaccharide (LPS) acceler ated complete Freund’s adjuvant (CFA) induced RA. Material and methods. In RAW 264.7 cells (lipopolysaccharide accelerated), nitric oxide (NO), tumor necrosis factor alpha (TNF-α), interleukin 6 (IL-6), inducible nitric oxide synthase (iNOS), and prostaglandin E2 (PGE2 ) were determined after treat ment with selegiline. Different arthritic parameters were analyzed after administration of selegiline in LPS accelerated CFA-in duced arthritis in rats. Results. LPS escalates NO, TNF-α, IL-6, iNOS, and PGE2 quantities in the RAW 264.7 cells, which was minimized by selegiline at 100 µg/mL and 150 µg/mL respectively. In rats, CFA induction causes a decrease in body weight, elevation of paw volume, splenic index, and arthritic index, which are further accelerated by LPS. 20 mg/kg of selegiline managed all these arthritic pa rameters effectively, including TNF-α, IL-6, and a few other biochemical parameters. Conclusion. Selegiline may be beneficial in RA extenuating joint and cartilage damage, and modulating inflammatory responses.
Simplified vs modified (reduced) ultrasound 6 joint score in assessing disease activity in rheumatoid arthritis patients
(Publishing Office of the University of Rzeszow, 2024-03) Gabal, Mervat Mamdouh Abo; Eldin, Amina Badr; Elserwy, Maha Ahmed; Mohammed, Mostafa Adel
Introduction and aim. With increasing ultrasound US assessment opportunities for tight rheumatoid arthritis (RA) management, more simplified accurate US-assessment is desired in clinical practice. Aim of the work is assessing modified vs simplified ultrasound 6-joint scores relevance in assessing rheumatoid arthritis disease activity. Material and methods. Fifty-five RA patients were subjected to detailed history, clinical, and musculoskeletal examination with disease activity assessment by clinical disease activity index, simple disease activity index and disease activity score in 28 joints. Com plete blood count, erythrocyte sedimentation rate, C-reactive protein, rheumatoid factor, anti-cyclic citrullinated peptide antibodies were done. Patients underwent US examination (gray-scale and power Doppler) for wrist, 2nd and 3rd metacarpophalangeal and knee joints bilaterally. Synovitis composite score was added. Two US indices were constructed: simplified S6 and modified M6 joint scores. Results. Statistical significant positive correlations were high between S6/M6 score parameters (total, grey-scale (GS), power doppler (PD), Composite) and disease activity markers. Both M6 and S6 scores differentiated mild-moderate and moderate-severe disease activity patients. However, only S6 score differentiated remission from mild disease activity patients. Conclusion. Ultrasound 6-joint scores (especially simplified S6) were rapid, easy and sensitive ultrasound tools assessing rheu matoid arthritis disease activity in clinical practice.
The effect of a physical therapy programme on the condition of upper limb muscles in patients with rheumatoid arthritis
(Publishing Office of the University of Rzeszow, 2023-12) Grygus, Igor; Nogas, Anzhela
Introduction and aim. Rheumatoid arthritis is a chronic progressive systemic disease of the connective tissue affecting the joints, mainly small, of the erosive-destructive polyarthritis type, and frequent systemic inflammatory damage to internal organs. The purpose of the research is to evaluate the effectiveness of physical therapy on the muscles of upper limbs in patients with rheumatoid arthritis by the dynamics of muscle strength and strength index. Material and methods. To determine the strength of the muscles of the affected upper limbs were used dynamometry, calculated strength index as a percentage to assess the functional ability of the affected limb. All patients were divided into control (n=92) and main (n=96) groups, taking into account the functional insufficiency of the joints. Results. After 6 months of physical therapy, muscle strength indicators in the main group of patients with 1st degree of functional joints insufficiency (FJI) in the affected right limb increased by 3.1 kg, in the left by 3 kg; with 2nd degree FJI – in the right limb by 4.2 kg, in the left – by 3.7 kg, significantly exceeded the same indicators in patients of the control group (р<0.05). Similarly, there was an increase in the strength index in the patients of the main group. Conclusion. Physical therapy technology has been developed and implemented effectively influenced the increase in muscle strength and strength index of affected upper limbs of the main group of patients with rheumatoid arthritis.