Przeglądanie według Temat "periodontitis"

Aktualnie wyświetlane 1 - 4 z 4

A new local therapy of periodontitis in the course of stomach pathology and tobacco smoke intoxication
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Romanova, Iuliia; Zolotukhina, Olena; Shnaider, Stanislav; Kravchenko, Lyudmila; Noneva, Nataliia
Introduction. Inflammatory periodontal diseases, arising against a background of stomach pathology from tobacco addiction remain an acute problem of modern dentistry. Aim. The experimental assessment of a new local treatment efficiency during therapy of simulated periodontitis with hyperacid gastritis and the tobacco smoke intoxication. Material and methods. The work was conducted in 2 stages. At the first stage, all experimental animals were divided into 4 groups: І — intact, II — with simulated periodontitis, III — with simulated periodontitis and hyperacid gastritis, IV — with simulated periodontitis with hyperacid gastritis and tobacco smoking. The local therapy efficiency was evaluated with the use of a new preparation for oral care and a comparison product conducted at the 2nd stage in rats with simulated periodontitis with hyperacid gastritis and tobacco smoking. Results. Experimental periodontitis with hyperacid gastritis and tobacco smoking provokes considerable changes in the periodontal tissues typical for the inflammatory process: lipid peroxidation activity rises and antioxidant system activity reduces. A local therapy in rats resulted in correction of detected metabolic disorders, improving removal of the damaging factors harmful influence and restoring the periodontal tissues condition. Conclusion. The medical efficiency of a new gel normalizes the influence of lipid peroxidation processes, inflammation and the oral cavity protective system activation during periodontitis which arises up against a background of the concomitant pathology of stomach – hyperacid gastritis.
Correlation between rheumatoid arthritis and periodontitis
(Publishing Office of the University of Rzeszow, 2022-12) Zielińska, Anna; Tabarkiewicz, Jacek
Introduction and aim. The association between periodontitis (PD) and rheumatoid arthritis (RA) has been analyzed and described in literature. Periodontal pathogens, such as “Porphyromonas gingivalis” and “Aggregatibacter actinomycetemcomitans” are pointed as the common factors for both diseases. In this work we demonstrate that treatment of dental and oral diseases is an unconditional requirement for patients with RA. Material and methods. PubMed was searched with the keyword “rheumatoid arthritis” and “periodontitis” from May 1999 to January 2022, showed 181 articles. Ultimately 72 articles were included in the review. Analysis of the literature. The above mentioned pathogens exhibit multiple mechanisms that disturb immune and inflammatory responses of the human organism. Those mechanisms lead to the periodontal disease (PD) that may activate the systematic reactions which in turn lead to intensification of systematic diseases such as rheumatoid arthritis (RA). P. gingivalis has the ability to expresses PAD enzyme (peptidylarginine deiminase) and activates the citrullization process. Moreover, the bacterium produces gingipain cysteine proteinases, which degrade the mechanisms of immunological system. The latter pathogen, A. actinomycetemcomitans, expresses hypercitrullization in neutrophils. Conclusion. Both pathogens influence inflammatory response of the organism, through the common pro-inflammatory mediators for periodontitis and rheumatoid arthritis, intensify the clinical manifestations of both diseases.
Evaluation of salivary alpha amylase activity in smokers with periodontitis, Khartoum state, 2023
(Publishing Office of the University of Rzeszow, 2023) Allah, Fatima Abd Alwhab Awad; Ahmed, Hafsa Ahmed Elrheima
Introduction and aim. Smoking widely affect oral health, including its role in the development of periodontitis. Saliva contains an antioxidant system and various enzymes. The study was designed to evaluate the activity of salivary alpha amylase among individuals who smoke and have periodontitis. Material and methods. A total of 100 participants were included, with 50 cases (cigarette smokers with periodontitis) and the remaining 50 nonsmokers with healthy periodontium as the control group. Saliva samples were collected to measure salivary alpha amylase activity. Results. Smokers with periodontitis had significantly higher levels of salivary alpha amylase compared to the control group (177.96±14.5 vs 94.04±19.6 IU/mL, p<0.001). Additionally, there was a weak negative correlation between the level of alpha amylase and the age of the patients (p=0.01, r=0.376). However, no correlation was found between the level of alpha amylase and the duration of smoking (p=0.584, r=0.079). Conclusion. There is a significant increase in salivary alpha amylase levels among smokers with periodontitis. No correlation was found between age and salivary alpha amylase levels. However, a weak positive correlation was observed between the duration of smoking and salivary alpha amylase activity.
The effect of thiocetam on the parameters of the nitric oxide system under the conditions of the experimental periodontitis and immobilization stress formation
(Publishing Office of the University of Rzeszow, 2024-06) Regeda, Mykhailo; Olekshij, Petro; Regeda-Furdychko, Maaryana; Furdychko, Lubomur; Kolishetska, Marta; Regeda, Stepan; Fil, Vitalii
Introduction and aim. The aim of this work is to study the parameters of the nitric oxide (NO) system in the blood of guinea pigs under the conditions of the experimental periodontitis (EP) and immobilization stress (IS) formation and to evaluate the effectiveness of thiocetam use. Material and methods. Experimental studies were performed on 50 guinea pigs (males, body weight 0.18–0.21 kg) which were divided into five groups (10 in each): the first group were intact animals as control; the second experimental group were animals with experimental periodontitis under conditions of immobilization stress (3rd day), the third group included guinea pigs with EP and IS on the 5th day of the combined model process, group IV – animals with EP and IS 15th day (without administration of thiocetam) and group V – animals on the 15th day of experiment with EP and IS after use of thiocetam. Results. As a result of this research, changes in the activity of the NO system in the blood were observed, namely an increase in the level of stable metabolites and an increase in the activity of total NO-synthase, which is accompanied by a compensatory inhibition of the L-arginine activity, and these indicators were most pronounced in the late stages of EP and IS formation. Conclusion. The use of thiocetam showed a corrective effect on the changed variables of NO metabolism in the peripheral blood of guinea pigs under the conditions of the EP and IS development.