Przeglądanie według Temat "lymphadenopathy"

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Case of multisystem inflammatory syndrome in adults
(Publishing Office of the University of Rzeszow, 2023-03) Dominik, Hanna; Dominik, Barbara
Introduction and aim. Multisystem inflammatory syndrome in adults (MIS-A) is a rare severe illness which is related to prior SARS-CoV2 infection in individuals>=21 years old. The condition was described few months after recognition of similar entity in children known as MIS-C (United Kingdom, April, 2020). The diagnosis of MIS-A is based on clinical symptoms andevidence of inflammation in laboratory markers. It is characterized by extrapulmonary organ dysfunction (cardiovascular, gastrointestinal), general symptoms such as fever, malaise, rash and deviations in blood tests (elevated level of ferritin, procalcitonin, CRP, IL-6, D-Dimer) with a previous or current SARS-CoV-2 infection. The purpose of this study is to present the syndrome on the basis of a clinical case example, to show the course of the disease, its symptoms and the result of applied treatment. Description of the case. The following case describes the clinical history, diagnostic process and applied treatment of 37-year old female patient who was admitted urgently to the hospital with a suspicion of sepsis originating from pharynx. The final diagnosis – MIS-A was settled after performing a broad panel of tests. Clinical picture was non- characteristic. The patient was successfully treated with steroids. Conclusion. MIS-A is a rare clinical entity linked with SARS-CoV-2 infection. The symptoms manifest from multiple organ systems and the diagnostic process may be challenging. The illness can be successfully treated with steroids.
Cytopathological diagnoses obtained in endobronchial ultrasound-guided transbronchial needle aspiration – a single-center one-year analysis
(Rzeszów University Press, 2025-06) Zając, Paweł; Kądziołka, Wojciech; Kaznowska, Ewa
Introduction and aim. Endobronchial ultrasound-guided fine needle aspiration (EBUS-FNA) is a widely adopted technique that replaces mediastinoscopy for the diagnosis of mediastinal lesions, significantly improving patient safety. This study assesses its diagnostic effectiveness and compares procedural quality with the existing literature, in order to identify characteristics of the patient population referred to the center. Material and methods. During a year-long retrospective analysis, data from 312 EBUS-FNA procedures were collected, resulting in a final study group of 274 patients. For patients initially without a definitive diagnosis, reinterventions were conducted, typically with additional EBUS or tissue biopsy, followed by precise statistical analyses and calculations. Results. The sensitivity of the EBUS examination to detect sarcoidosis, non-small cell lung cancer, small cell lung cancer, and lymphoproliferative disorders was determined to be 87.36%, 87.23%, 91.30% and 20%, respectively, based on false negative findings. Among patients who received a final diagnosis (n=237), a significant majority, i.e. 206 individuals or 86.92%, obtained it based on the first intervention. Conclusion. EBUS-TBNA is an effective method to diagnose the cause of mediastinal lymphadenopathy, allowing for a definitive diagnosis in a significant majority of patients in the first intervention and showing high sensitivity in detecting metastatic malignant lymph node involvement and sarcoidosis.