Przeglądanie według Temat "lipid profile"

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Biochemical and cellular (liver and kidney) restorative properties of garlic (Allium sativum) aqueous extract in cow brain-induced hypercholesterolemic model Swiss albino mice
(Publishing Office of the University of Rzeszow, 2023-09) Kundu, Swarup Kumar; Khan, Mohammad Abu Hadi Noor Ali; Das, Shonkor Kumar
Introduction and aim. Garlic is one of the most popular traditional medicinal herbs which has a number of desirable health benefits. The study was designed to depict the improvement of serum biochemical parameters as well as the histomorphological recovery potential of garlic aqueous extract in hypercholesterolemic mice. Material and methods. A total of thirty Swiss albino mice weighing 24±5g and aged 5 weeks were randomly divided into three groups. Group A: supplied standard mice pellet and water; Group B: standard mice pellet + hypercholesterolemic diet (cow brain: 2 g/kg b.w.t.); and Group C: standard mice pellet + hypercholesterolemic diet (cow brain: 2 g/kg b.w.t.) + garlic extract (25 ml/kg b.w.t.). After four weeks of experimental tenure, samples (blood, liver, and kidney) were collected from each group of mice for serum biochemical analysis and histomorphological study. Results. Compared with hypercholesterolemic mice, total cholesterol (TC), triglyceride (TG) concentration, and low-density lipoprotein (LDL) levels significantly decreased respectively by 7%, 20% and 48% along with high-density lipoprotein (HDL) levels significantly increased by 47% in garlic extract supplemented group. Based on the histological evaluation in the liver sample of group C, both portal and central veins were normal, and fat droplets were not found in the hepatocytes which were found in the liver of group B. On the other hand, unchanged renal cortex, glomerulus, Bowman’s space, and kidney tubules were seen in group C. Conclusion. Therefore, the above findings of the present research would assist to provide affirmation about the cholesterol-decreasing and cellular restoration potentiality of garlic aqueous extract.
Evaluation of lipid profile, malondialdehyde, hemoglobin and ferritin in Iraqi women with polycystic ovarian syndrome
(Rzeszów University Press, 2025-06) Shenta, Ashwaq A.; Al-Maliki, Abbas D.M.; Abou-Turab, Mufid K.
Introduction and aim. The concept of polycystic ovarian syndrome (PCOS) is defined as a biochemical complex statement that affects many young and adult females (single and married). This case presents a variety of medical and biological concerns related to the reproductive system. The aim of the study was to investigate and estimate the levels of the lipid profile, malondialdehyde, hemoglobin and ferritin in women with PCOS. Material and methods. Blood samples were collected from 180 women who were divided into 100 PCOS patients and 80 healthy women according to the variables of age and body mass index. Triglycerides (TG) levels were measured in blood sera by spectrophotometric method, total cholesterol (TC) levels were estimated using enzymatic methods and the high-density lipoprotein (HDL) was determined by the HDL-phosphotungstic acid precipitation method. Results. Total cholesterol, triglyceride, low-density lipoproteins, and very low-density lipoproteins recorded a highly significant increase (p<0.001) whereas high-density lipoproteins decreased significantly (p<0.001) in women with PCOS women when compared to the control group depending on age and body mass index variables. The results showed that hemoglobin, ferritin and malondialdehyde levels increased significantly (p<0.001) in female PCOS compared to the healthy group according to age and body mass index variables. Conclusion. The importance of thorough medical management of PCOS includes minimizing oxidative stress, metabolic function, and lipid profiles for avoidance of chronic health conditions.
Silica nanoparticles from melon seed husk improves atherogenic, hematologic and oxidative stress indices in male Sprague Dawley rats exposed to Ni, Al and Ni/Al mixtures
(Rzeszów University Press, 2025-06) Anyachor, Chidinma P.; Dokubo, Awolayeofori; Ajibo, Doris N.; Dooka, Baridoo Donatus; Ugwu, Theresa C.; Husaini, Danladi C.; Orisakwe, Orish E.
Introduction and aim. With the increased awareness from circular bioeconomy that focuses on ‘no waste’ generation mantra, various technologies have been developed to valorize these wastes into useful products, including melon seed husk. The aim of the study was to evaluate the effects of silica nanoparticles from melon seed husk (SiNPs MSH) against Ni, Al, and Ni/Al mixture-induced hematotoxicity and lipotoxicity in Sprague Dawley rats. Material and methods. Fifty-six male Sprague Dawley, 6 to 8 weeks and weighing 220 to 250 g, were randomly allocated to eight groups (n=7). Group 1 received deionized water only (control), groups 2, 3 and 4 (exposed groups) received the Ni/Al mixture, 0.2 mg/kg Ni and 1.0 mg/kg Al, while groups 5 to 8 received the Ni/Al mixture, Ni, and Al plus 100, 200 and 400 mg/kg of SiNPs respectively for 90 days. Blood samples were collected for biochemical investigation. Results. Ni, Al and Ni/Al groups showed significant (p<0.05) alteration (p <0.05) in the classic lipid profile, hematological and oxidative stress markers compared to the control. Co-administration with SiNPs did not show significant (p>0.05) difference in these parameters compared to the control. Conclusion. MSH SiNPs reversed Ni, Al, and Ni/Al mixture mediated hemotoxicity and elevated superoxide dismutase, catalase, and glutathione probably via metal chelation.