Przeglądanie według Temat "genetics"

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Genetic factors contributing to the development of inguinal hernias – a narrative review
(Publishing Office of the University of Rzeszow, 2024-06) Kalali, Datis
Introduction and aim. Inguinal hernias are one of the major disorders in the field of general and visceral surgery and can be viewed as multifactorial diseases. Although the molecular mechanism that led to predistortion to inguinal herniation still remain unclear, is well known that defects leading to improper closure of the inguinal canal during fetal development and mechanisms contributing to weaker muscles of the abdominal wall can greatly increase the risk of developing the latter disease. Material and methods. A literature search was performed in all major electronic databases using keywords and Boolean operators to retrieve all available literature related to the topic. Due to the narrative nature of the review, there were no specific inclusion and exclusion criteria. Analysis of the literature. Genetic factors, undoubtedly, can interfere with these mechanisms and therefore play major role in developing hernias. To this end, the present narrative review provides an overview of genes with altered expression and genetic polymorphisms associated with inguinal herniation. Moreover, the results of genome-wide association studies (GWAS) exploring susceptible genetic loci associated with the disease have been reported. Conclusion. Nevertheless, more case-control studies and GWAS need to be conducted in different ethnic populations so as to provide better insights into the topic.
Na tropie polskiego thrillera medycznego w powieściach początku XX wieku
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Trześniewska, Agnieszka
A Polish medical thriller is a response to the American prototype. It seems that the native authors are trying to work out new determinants of the species, which will stand up to Polish reality. However, writers do not overlook topics that are important from a medical thriller point of view, such as the moral choices of doctors, the uncontrolled progress of science and technology. The new species on Polish soil did not manage to be protected by literary themes taken from American medical thrillers. Polish medical thrillers are forms of hybrids. Writers scooping out elements of the crime, psychological novels, teenage novels, or folklore literature are woven into the American medical thriller convention. Not all the novels discussed here can be called medical thrillers. Doktor śmierć of Jacek Caba appears closest to the American prototype. The writer, like American medical thriller authors, is a doctor and more credible in his narrative, based on his knowledge and experience.