Przeglądanie według Temat "diabetes"

Aktualnie wyświetlane 1 - 7 z 7

Complex relationships between endocrinopathies and obstructive sleep apnea syndrome
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2017) Szymańska, Monika; Mizerski, Grzegorz; Kiciński, Paweł
Sleep-related disordered breathing (SRDB) is a term covering a heterogeneous group of conditions with a similar clinical picture yet different pathogenesis. Nocturnal episodes of obstructive apnoea, leading to repeated periods of desaturation and re-oxygenation, activate chemoreceptors and increase the activity of the sympathetic as well as renin-angiotensin-aldosterone system. Moreover, the generation of free radicals and proinflammatory cytokines increases. All the above mentioned disturbances interfere with the function of endocrine glands. On the other hand, many endocrine disorders are associated with an increased risk of obstructive sleep apnoea syndrome (OSAS). In this paper, we discuss relationships between selected endocrinopathies and OSAS.
Influence of food-derived advanced glycation end products on health
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Galiniak, Sabina; Biesiadecki, Marek
Introduction. Advanced glycation end products (AGEs) are compounds formed endogenously in the human body. Besides this source of AGEs, they also exist in food and can be generated during cooking. Enhanced endogenous generation and intake of dietary AGEs have physiological impact on human health and are associated with progression of many diseases, including diabetes and its complications. Aim. The purpose of this review is to the present the current state of knowledge about the various negative effects of advanced glycation end products on human health. Materials and methods. This study is based on analysis of literature reporting the content of AGEs in food and high or low AGEs dietary interventions in human and animal subjects. Results. Literature data present databases gathering description of AGEs determinations in various types of food. Conclusions. Excessive consumption of AGEs-rich products, especially abundant in protein and fat or cooked for a long time at high temperature, may contribute to the deterioration of human health, including development of hypertension, insulin resistance, and diabetic complications.
Koszty leczenia wybranych chorób cywilizacyjnych w opiniach respondentów
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2015) Wyszkowska, Zofia
Systematycznie wzrasta liczba osób chorujących na choroby cywilizacyjne w Polsce, w Europie i na świecie. Rozwiązywanie problemów związanych z tymi chorobami jest dużym wyzwaniem stawianym przed ekonomiką zdrowia i systemami ochrony zdrowia, dlatego prowadzenie badań dotyczących określenia poziomu kosztów tych chorób wydaje się ważne. Celem pracy jest przedstawienie poziomu wybranych kosztów ponoszonych przez chorych na cukrzycę i astmę. Badanie przeprowadzono wśród chorych w wybranych placówkach ochrony zdrowia w Bydgoszczy. Korzystano z kwestionariusza ankiety. W badaniu uczestniczyło 285 osób. Prowadzono wywiad z pacjentami oczekującymi na wizytę u lekarza specjalisty w poradniach szpitalnych leczących dane choroby. Przy pomocy programu Excel utworzono bazę danych dla prowadzonych obliczeń. W badaniu uwzględniono strukturę płci chorych i ich wiek, zamieszkiwanie w mieście lub na wsi, status zawodowy, uzyskiwany poziom dochodu przypadający na jedną osobę w gospodarstwie domowym, czas trwania choroby, częstotliwość przyjmowania leków, korzystanie z prywatnych wizyt u lekarzy specjalistów, poziom ponoszonych wydatków finansowych na te wizyty, poziom miesięcznych wydatków na leki. Wykonano porównanie poziomu ponoszonych kosztów przez chorych na astmę i cukrzycę. Badania wykazały, że astmatycy częściej aniżeli chorzy na cukrzycę korzystają z prywatnych wizyt specjalistycznych i ponoszą wyższe w porównaniu z cukrzykami wydatki na ten cel. Ponad połowa respondentów zaznaczyła, że miesięczne wydatki związane z chorobą cukrzycą lub astmą stanowią duże obciążenie dla budżetu domowego.
Obesity-diabetes-endocrinopathy – the metabolic connection
(Publishing Office of the University of Rzeszow, 2022-12) Kozakowski, Jarosław; Dudek, Piotr; Zgliczyński, Wojciech
Introduction and aim. The article outlines the mechanisms of interrelationships between obesity, type 2 diabetes, and certain disorders of the endocrine system. The paper explains how insulin resistance develops, which is a key link between obesity and several related disorders, how hypercortisolemia leads to the development of obesity and glucose intolerance, why thyroid dysfunctions are bidirectionally associated with metabolic disturbances, in what way excessive body weight leads to the hypogonadism in men, or how menopause promotes the development of abdominal obesity, carbohydrate intolerance and, in some cases type 2 diabetes. Material and methods. Scientific articles were reviewed by searching for information using the online database with scientific articles, including PubMed, Google Scholar and other available scientific databases. Analysis of the literature. The huge prevalence of obesity, diabetes, and hormonal disorders (e.g., autoimmune thyroid disease, female and male hypogonadism) over the contemporary world together with the serious health consequences of these conditions makes up a specific triangle of metabolic connections, increasingly absorbing the human, organizational and financial resources of health systems. Conclusion. Recognizing the relationship between the components of this triangle and understanding the risks arising from this phenomenon may allow to effectively reduce its impact on our health.
Ocena wydolności fizycznej dzieci i młodzieży chorych na cukrzycę typu 1 przy zastosowaniu testu spiroergometrycznego
(Uniwersytet Rzeszowski, 2024-03-21) Wołoszyn, Filip
Cukrzyca typu 1 (T1DM) to choroba metaboliczna związana z brakiem insuliny. Dzieci i młodzież z T1DM często doświadczają ograniczeń w wykonywaniu ćwiczeń fizycznych. Celem pracy było zbadanie wydolności fizycznej dzieci i młodzieży z T1DM, uwzględniając skład ciała, czas choroby i poziom hemoglobiny glikowanej. Porównano wyniki z grupą kontrolną zdrowych dzieci aktywnych i nieaktywnych fizycznie. Uczestnicy przeszli test spiroergometryczny i ocenę składu ciała. Osoby z T1DM wykazywały niższą wydolność fizyczną i odmienne parametry fizjologiczne. Analiza parametrów jest istotna dla monitorowania zdrowia i bezpieczeństwa podczas aktywności fizycznej u dzieci z T1DM.
Prevalence of depression in Indian patients with type 2 diabetes mellitus and/or hypertension: DEPTH Study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Lalwani, Raj Kumar; Shah, Jayesh Dashrathlal; Chatterjea, Tapas; Nadakuduru, Papa Rao; Erande, Suhas
Introduction. Depression, a common psychiatric mood disorder, is a leading cause of disability and a significant contributor to the overall global burden of disease. Aim. To determine the prevalence of depression in patients with controlled and uncontrolled type-2 diabetes mellitus (T2DM) and/or hypertension (HTN) in India. The association of depression with socio-demographic profile and clinical risk factors was also assessed. Material and methods. In this cross-sectional epidemiological study, T2DM and/or HTN patients attending outpatient department at tertiary care hospitals and private clinics across 54 cities in India were enrolled. The primary outcome measure was to determine the prevalence of depression in T2DM, HTN and T2DM + HTN patients. Association of depression with patients’ demography, socio-economic status, anxiety, and clinically diagnosed insomnia were also investigated. Results. Of 1829 patients, the prevalence of depression in T2DM, HTN and T2DM+HTN cases were found to be 51.03%, 46.94% and 48.64%, respectively. A higher proportion of patients with uncontrolled T2DM and HTN reported depression (T2DM: 77.64% vs. 22.36%; HTN: 72.49% vs. 27.51%). There was a significant association between anxiety and severity of depression across all indications (p<0.0001). Depression was significantly associated with complications in T2DM (p=0.0001) and comorbidities in T2DM + HTN (p=0.0023) cases. Conclusion. Depression is highly prevalent and has a direct significant association with various socio-demographic variables and anxiety in Indian patients with T2DM and/or HTN.
Risk factors for cancer development in type 2 diabetes. A retrospective case-control study.
(2016-08-19) Dąbrowski, Mariusz; Szymańska-Garbacz, Elektra; Miszczyszyn, Zofia; Dereziński, Tadeusz; Czupryniak, Leszek
Abstract Background. The risk of several types of cancer is increased in type 2 diabetes mellitus. The earliest possible diagnosis of cancer – difficult within regular outpatient diabetes care - is of utmost importance for patients’ survival. The aim of this multicenter, retrospective (years 1998-2015), case-control study was to identify risk factors associated with malignancy in subjects with diabetes treated in a typical outpatient setting. Methods. In the databases of 3 diabetic and 1 primary care clinics 203 patients (115 women) with type 2 diabetes mellitus who developed malignancy while treated for diabetes were identified. The control group consisted of 203 strictly age- and gender matched subjects with type 2 diabetes without cancer. Factors associated with diabetes: disease duration, antidiabetic medications use and metabolic control of diabetes were analyzed. Also other variables: BMI (body mass index), smoking habits, place of residence and comorbidities were included into analysis. Results. The most prevalent malignancies in men and women together were breast cancer (20.7%) and colorectal cancer (16.3%). HbA1c (hemoglobin A1c) level ≥8.5%, obesity and insulin treatment in dose-dependent and time-varying manner demonstrated significant association with increased risk of malignancy, while metformin use was associated with a lower risk of cancer. Diabetes duration, comorbidities, smoking habits, place of residence and aspirin use did not show significant association with risk of malignancy. Conclusions. In the outpatient setting the obese patients with poorly controlled insulin treated type 2 diabetes mellitus should be rigorously assessed towards malignancies, particularly breast cancer in women and colorectal cancer in men.