Przeglądanie według Temat "cardiovascular diseases"

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Exploring the versatility of ciclopirox – from anti-fungal to anticancer agent and beyond
(Publishing Office of the University of Rzeszow, 2023-12) Singh, Dhishank; Kaur, Ginpreet; Chintamaneni, Meena; Joshi, Hemant; Ramniwas, Seema; Tuli, Hardeep Singh
Introduction and aim. Ciclopirox has been treating fungal infections for decades. Recent studies suggest ciclopirox may be repurposed to treat cancer, viral infections, and neurological disorders. Ciclopirox exerts anticancer by inhibiting multiple pathways of cancer cell growth and survival and anti-viral actions by reducing viral replication and altering the host immunological response to viral infection. Recent research suggests that ciclopirox may protect against neurodegenerative illnesses including Alzheimer’s and Parkinson’s. This narrative review shows ciclopirox’s potential to treat cancer, viral infections, and neurological diseases. Material and methods. Current relevant research publications focused on ciclopirox and its repurposing medicinal potential, therefore a well-designed technique was used to find them. „Ciclopirox”, „Anti-fungal”, „Anti-cancer”, „Repurposing”, and „Therapeutic potential” were used to search PubMed, Web of Science, EMBASE, and Google Scholar. Analysis of literature. Ciclopirox may reduce oxidative stress and inflammation, which may cause several illnesses. Overall, the repurposing of ciclopirox for the treatment of cancer, viral infections, and neurodegenerative disorders represents a promising avenue of research that warrants further investigation. Conclusion. It was concluded that CPX and olamine derivatives as outstanding antifungal medications, as well as provide information on ongoing research to use them for other illnesses.
Knowledge of modifiable risk factors for cardiovascular diseases among university undergraduates in Ibadan, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Oyewole, Oyediran Emmanuel; Solabi, Ayodele
Introduction. Undergraduates in many institutions live a lifestyle that could predispose them to non-communicable diseases (NCDs) including cardiovascular-related. Previous studies on modifiable risk factors (MRFs) against NCDs had focused mainly on adults, whereas young people should be prime targets for prevention programmes. Aim. This study was aimed at investigating knowledge of MRFs against cardiovascular diseases (CVDs) among university undergraduates in Ibadan, Nigeria. Material and methods. A descriptive cross-sectional design was adopted, where 500 undergraduates participated. Data were collected using Focus Group Discussion (FGD) guide and validated questionnaire. Data analyses were conducted using thematic approach and bivariate methods at 5% levels of significance, respectively. Results. Mean age was 22.8 }3.0 years and 51.4% were females. The majority reported that their fathers (82.8%) and mothers (83.0%) had no hypertension history. The FGD revealed that students were knowledgeable of MRFs and preventive behaviours but still engaged in unhealthy lifestyle practices. The MRFs identified included excessive alcohol consumption (85.4%), unhealthy diet (77.6%), physical inactivity (75.2%) and smoking (70.2%). Respondents (56.4%) had good knowledge of MRFs against CVDs; 57.0% had fair lifestyle practices and 54.8% had good knowledge of preventive behaviour against CVDs. Conclusion. Gender was significantly associated with knowledge of CVDs preventive behaviours. Institutional-based lifestyle modification programmes, using peer group education is suggested.