Przeglądanie według Temat "autoimmune diseases"

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A patient with overlap syndrome: systemic lupus erythematosus, dermatomyositis, and Sjögren’s syndrome – a rare overlapping diseases case report
(Publishing Office of the University of Rzeszow, 2023-09) Sokołowska, Aldona; Iwański, Mateusz; Dąbrowski, Piotr
Introduction and aim. Autoimmune rheumatic diseases are a group of disorders with similar clinical, laboratory and immunological manifestations. Connective tissue diseases include systemic scleroderma, dermatomyositis or polymyositis, Sjögren’s syndrome, rheumatoid arthritis, and systemic lupus erythematosus. If the patient meets the diagnostic criteria for at least two of these diseases and has specific serologic markers, a diagnosis of overlap syndrome is possible. Description of the case. This case describes a 27-year-old man who had a history of paroxysmal fever, night sweats, erythema-like skin lesions on the forearms and lower legs, a feeling of progressive muscle weakness especially in the proximal muscles, and dry mouth. The patient was diagnosed with an overlap syndrome: systemic lupus erythematosus, dermatomyositis, and Sjögren’s syndrome. Conclusion. Overlap syndrome is difficult to treat due to its multisystem nature, requiring a symptomatic therapeutic approach and careful control of medication doses to reduce side effects while controlling disease activity.
Autoimmune diseases and their various manifestations in the oral cavity – a systematic review
(Publishing Office of the University of Rzeszow, 2023) Lin, Shin-Yi; Huang, Yu-Wei; Błochowiak, Katarzyna
Introduction and aim. Oral manifestation of the disorder is the leading cause of common initial features of most autoimmune diseases. Therefore, this study aimed to present different oral manifestations of selected autoimmune diseases. Material and methods. We systematically reviewed the etiology, signs and symptoms, oral manifestations, epidemiology, diagnosis, treatment plan, and prognosis. We searched the articles on PubMed, Google Scholar and Web of Science for the following search term: Behcet’s disease, lichen planus, mucous membrane pemphigoid and bullous pemphigoid, pemphigus vulgarisms and paraneoplastic pemphigus, rheumatoid arthritis, Sjögren’s syndrome, IgG4-related disease, systemic lupus erythematous, and granulomatosis with polyangitis. Analysis of the literature. We conducted that the disorder’s oral manifestation causes most autoimmune illnesses’ earliest symptoms. Conclusion. Clinical-pathological is a piece of requisite knowledge for the dentist to recognize and diagnose in the early phase of the symptoms.
Stan odżywienia i skład ciała dzieci z wybranymi chorobami autoimmunizacyjnymi – ocena za pomocą pomiarów antropometrycznych i bioimpedancji
(2015-02-23) Więch, Paweł
Głównym celem podjętych badań była ocena stanu odżywienia i składu ciała dzieci z wybranymi chorobami autoimmunizacyjnymi przy pomocy wskaźników antropometrycznych i bioimpedancji. Badania przeprowadzono w okresie od marca 2012 roku do sierpnia 2014 roku. Badaniami objęto 248 dzieci chorych (celiakia-51, WZJG-34, ChLC-25, cukrzyca-138) w wieku 4-18 lat hospitalizowanych w Klinicznym Oddziale Pediatrii z nr 2 w Rzeszowie. W pierwszej kolejności analizą objęto 100 dzieci z nowo rozpoznaną chorobą autoimmunizacyjną, do których przyporządkowano drogą losowania 100 dzieci zdrowych, dopasowanych pod względem płci i wieku (age- and sex matched controls). Zaburzenia stanu odżywienia dotyczyły 31% dzieci nowo zdiagnozowanych (niedobór masy ciała 18% vs 13% nadwaga/otyłość). Wykazano statystycznie istotną dodatnią korelację pomiędzy FM vs BMI (r=0,878), FFM vs WMC (r=0,873), FMI vs Cole (r=0,820) oraz FFMI vs WMC (r=0,803) w grupie dzieci chorych (nowe rozpoznania). U dzieci z nowym rozpoznaniem celiakii, po rocznym okresie stosowania diety bezglutenowej, zauważono statystycznie istotny wzrost wszystkich komponentów beztłuszczowej masy ciała (p < 0,05). Zaobserwowano niższe wartości FFM u dzieci z aktywną postacią IBD (WZJG: 13,6% < 2,3 centyl, 22,7% < 25 centyl vs ChLC: 22,2% < 2,3 centyl, 33,3% < 9,2 centyl. Dzieci z nowo zdiagnozowaną cukrzycą typu 1, charakteryzowały się obniżoną wartością FFM (głównie BCM [p=0,0060] i MM [p=0,0068]).
Unmasking the nature of granulomatosis with polyangiitis – a diagnostic odyssey revealed through a compelling case report
(Publishing Office of the University of Rzeszow, 2024-06) Sajdak, Piotr; Krużel, Aleksandra; Stodolak, Marcel; Bednarski, Artur; Ziajor, Seweryn; Turski, Mikołaj; Żurowska, Klaudia; Kłos, Kamil; Tomasik, Justyna; Dębik, Marika; Szydłowski, Łukasz
Introduction and aim. Granulomatosis with polyangiitis (GPA), formerly known as Wegener’s granulomatosis, presents a formidable challenge in the realm of autoimmune diseases. Granulomatosis, characterized by vasculitis and granuloma formation, exhibits diverse clinical manifestations. The rarity of GPA is evident, with an estimated incidence between 0.4 and 11.9 cases per 1 million person-years. The aim of this report is to show the complex diagnostic challenges inherent in GPA, demonstrating the diagnostic process from initial symptoms. Description of the case. This case report unfolds the diagnostic journey of a 52-year-old Caucasian male. The presented case, initially suspected as a respiratory infection, led to a comprehensive investigation owing to persistent symptoms, abnormal blood counts, and elevated inflammatory markers. This narrative aims to depict the patient’s diagnostic journey. Key diagnostic tools include ANCA testing, imaging studies, and tissue biopsy. Pulmonary nodules, lymphangitic changes, and renal involvement culminating in a GPA diagnosis confirmed by positive ANCA and anti-PR3 antibodies. The successful management of this case involved a tailored therapeutic regimen, including cyclophosphamide and methylprednisolone, addressing both vasculitic and renal components. Conclusion. This case contributes to the understanding of atypical presentations of GPA, emphasizing the importance of a holistic and dynamic diagnostic approach.