European Journal of Clinical and Experimental Medicine T.16, z. 4 (2018)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/4493

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How genetic predispositions may have impact on injury and success in sport
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Czarnik-Kwaśniak, Justyna; Kwaśniak, Konrad; Tabarkiewicz, Jacek
Introduction. Studies investigating the determinants of physical endurance were initiated nearly 30 years ago. The research was inspired by the curiosity to find out about the nature of talent for sport and why some athletes are better than others, despite the same or even greater effort in training routine, diet and the supplementation. An attempt was therefore made to determine the genotype of a perfect athlete, but conducted research showed that it is a very difficult task. Although 140 genes were proposed to affect of ideal sportsman fitness, scientists are still far from formulating answers about the nature of physical abilities and genotype. Aim. Our main goal was to review the literature about the selected genes and polymorphisms which are most often investigated in the context in relation to injury in sports. Materials and methods. Analysis of literature from US National Library of Medicine, National Institutes of Health, PubMED, Google Scholar. Results. We review the selected genes and polymorphisms which are most often investigated in the context in relation to injury in sports, we also present the function of genetic variants prevalent in athletes which are able to achieve better physiological adaptation during the training. Conclusions. There are probably more than 140 genes involved in physical performance. Changes in even one nucleotide within the gene (SNP) can improve the body’s adaptation to better physical performance and the frequency of injury to athletes.
Medicinal & Aromatic Plants
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Domka, Wojciech; Aebisher, David; Truszkiewicz, Adrian; Bartusik-Aebisher, Dorota
Introduction. The objective of this study is to discuss the potential of plants species in medical applications. Aim. The main purpose of this study is to discuss ethnobotanically selected plants used in medicine. Materials and methods. We analysed literature and collected information, data, and examples of selected plants used in medicine. Results. The literature shows that for several decades, the properties of medicinal plants have been investigated and reported in the biomedical and pharmaceutical literature. Conclusions. This review includes studies on plants material. The properties of various plants physiology were discuuses with the option for the use in phythotherapy.
Inflammatory bowel disease: the function of metalloproteinases
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Pasternak, Grzegorz; Aebisher, David; Filip, Rafał; Bartusik-Aebisher, Dorota
Introduction. Inflammatory bowel disease (IBD) is a group of inflammatory conditions of the colon and small intestine. Aim. The aim of this work was to review the current literature regarding matrix metalloproteinases. The databases such as PubMed, ScienceDirect and Springer were utilized to search the literature for relevant articles. Materials and methods. An analysis of literature. We collected information, data, and examples of the function of metalloproteinases. Results. Herein we show that metalloproteinases play a role in such processes as the immune response, angiogenesis, the epithelial barrier function, fibrosis induced by the inflammatory process, and in the process of carcinogenesis. Conclusions. Further studies on the role of metalloproteinases in the process of carcinogenesis associated with inflammatory bowel diseases are required.
A comparative analysis of the rehabilitation course of two patients after the implantation of an artificial hip joint
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Handkiewicz, Krzysztof
Introduction. Endoprosthetics is the most effective method of returning to a normal way of life without pain. The key element is the post-operative rehabilitation program where a patient has to comply with certain rules and principles. The rehabilitation also includes the family of the patient. Each person, after any surgery requires an individual approach, and no patient can be commonly treated. Aim. The aim of the article is to compare the effects of an early rehabilitation after the implantation of an artificial hip joint in two patient cases. Description of the cases. This research was conducted at Bodden-Klinken GmbH. An individual case study was used, based on an example of two patients at the age of 59 who had implantation of an artificial hip joint. The carried out rehabilitation of the patients was conducted without any disruptions. Patients were able to freely walk on crutches nine days after the procedure. Conclusions. In the cases analyzed, the rehabilitation course was described until the ninth day after implantation of an artificial hip joint. High results in terms of patient rehabilitation were achieved. Furthermore, in order to continue their therapy, they were referred to the sanatorium.
Evaluation of the knowledge of the issues related to human papillomavirus infections within young women
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Węgorowski, Paweł; Michalik, Joanna; Turkowska, Karolina; Stanisławek, Andrzej; Wolski, Dariusz; Bieńko, Marek; Radzki, Radosław P.
Introduction. Human papillomavirus infections are frequent in on average 9% to 13% of the female population, and the risk of infection throughout life exceeds 50%. The HPV virus causes changes in the mucous membranes and the skin of the genital area in both women and men. Aim. This paper presents epidemiology, prophylaxis, diagnostics and treatment of HPV and cervical cancer infections. In addition, the knowledge of issues related to human papillomavirus infection among young women was assessed. Materials and methods. The diagnostic survey method was used to carry out the research. The research tool was a questionnaire of own authorship consisting of 41 questions. The research group consisted of 240 women. The research was carried out from June to September 2016 at the Chodźki Medical Center and the Luxmed facility in Lublin. Results. There is a relationship between the education of the respondents and their knowledge about the human papillomavirus infection. The studies did not show a significant relationship between the self-esteem of the studied women and whether they were vaccinated against the HPV virus (Chi-square = 0.362, p = 0.547). Conclusions. The general level of knowledge on issues related to human papillomavirus infection among young women is at the secondary level. A higher level of general knowledge was shown by women with better education, related to the medical and biological sciences. The self-assessment of the respondents coincides with the general knowledge, based on detailed questions, on issues related to HPV infection. Promoting knowledge about HPV infection is unsatisfactory.
Provincial Commission for Adjudication of Medical Events as an alternative choice of indemnization of medical damage – functional and system analysis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Porada, Sławomir; Hejda, Paulina; Hubert-Lutecka, Agnieszka; Binkowska-Bury, Monika
Introduction. Since January 1, 2012 a patient who suffered so-called medical damage has the right to choose between two alternative routes to compensate for medical damages, i.e. legal or extrajudicial. Aim. To present the consequences of the out-of-court compensation for medical damages for patients on the basis of existing legal acts and the literature. Materials and methods. The analysis of legal acts and literature regarding extrajudicial compensation. Conclusions. The provisions regulating the out-of-court medical compensation for patients are inconsistent and unclear. As a result of the application of the regulations in force by Provincial Commission for Adjudication of Medical Events, there are difficulties for the injured patients to receive compensation or redress. The analysis of legal acts and literature shows that only court proceedings are the most effective way to assert their rights for patients who have suffered so-called medical damage.
Symptoms of menopause and health of women during perimenopause
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Nagórska, Małgorzata; Sowa, Aneta; Wardak, Katarzyna; Lesińska-Sawicka, Małgorzata
Introduction. Perimenopausal age is the time in a woman’s life, when her reproductive capacity declines. Characteristic symptoms in the majority of systems accompany this process. Aim. The aim of the study was to determine the symptoms of menopause and investigate the most common health problems in perimenopausal women. Materials and methods. The study involved 180 women in perimenopausal age (45-55 years). The subjects were mainly residents of rural areas (65%) and married (84%). Most of them declared secondary education (57%). A questionnaire developed by the authors was used in the study. Results. Most women observed typical menopausal symptoms mostly between 45 and 49 years of age. Most often, these were hot flushes, the second place was night sweats, and the third place was insomnia. Almost 40% of women are treated for chronic diseases, most of them for hypertension, thyroid disease and diabetes. Conclusions. The changes associated with perimenopausal age in the majority of respondents include genitourinary system, respiratory system, skeletal system and metabolic changes. Level of education influences the level of knowledge among women on the menopause. Women from rural areas used non-pharmacological methods to mitigate the symptoms of menopause to a greater extent.
The effect of alcohol on neuroglia in the developing brain and in adults
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Krawczyk-Marć, Izabela; Galiniak, Sabina; Sęk-Mastej, Anna; Marć, Mateusz; Orkisz, Stanisław; Wawrzyniak, Agata
Introduction. During puberty, the young body undergoes transformation not only within the reproductive and hormonal systems, but also significant changes in the central nervous system (CNS). Matured neural connections improve the integration of distant brain regions, the plasticity of neurons increases, and thus specialization of the brain occurs in the performance of specific tasks. During these transformations, both neurons and the accompanying neuroglia are sensitive to all toxic factors, among which ethanol occupies a special place. It causes an increase in the activity of glial cells, which by directing pro-inflammatory cytokines directly contribute to the death of apoptotic neurons. A long-lasting and irreversible impairment of brain function, especially in the hippocampus occurs as a result of alcohol abuse during the period of development. Aim. This paper presents an overview of current knowledge about the effects of alcohol on neuroglia in the developing brain and in adults. Materials and methods. The literature review of the following databases has been conducted: EBSCO, PubMed, Science Direct, Springer Link. Conclusions. The results of alcohol research have shown that it affects the neurotransmission and fluidity of cell membranes, changing the activity of neurons. By binding to GABA receptor (GABA) and N-methyl-D-aspartate receptors (NMDA receptor for glutamate), ethanol suppresses brain function. In addition to increased sensitivity and susceptibility to the addictive effects of ethanol, the neurogeneration activity is intensified followed by the induction and release of pro-inflammatory cytokines, which in the first stage disrupt the cortical function hindering logical thinking and disrupting the limbic system, directly affecting the memory and learning processes. Next, the cerebellum is attacked, which results in the impairment of balance and motor coordination, and consequently acts on the brain stem, directly affecting the respiratory and circulatory control centers.
Diversification of results of orientating questionnaire of motoric and psycho-social development in regard to the level of educational maturity (school readiness) in prematurely born children
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Perenc, Lidia; Cyran-Grzebyk, Barbara; Zajkiewicz, Katarzyna; Walicka-Cupryś, Katarzyna
Introduction. Currently, one of the most common problems in neonatology is the occurrence of distant consequences of prematurity. In infants, toddlers, and children with special problems, there can be disorders in psychomotor development and in growing, and later also intellectual and cognitive disorders. Pre-school and early-school age is particularly significant in the lives of prematurely born children. In this period, usually beside the stage of somatic growth, there is intensive physical and mental development and intellectual disorders may appear. Aim. Assessment of preterm training in motor skills and psychosocial development Materials and methods. The research group consisted of 61 prematurely born children aged 5-8. Perinatal interviews were collected and basic anthropometric measurements were performed. Results. There is no statistical significance between questionnaire results in particular areas of development, summary, age, gender, subsequent pregnancies, number of fetuses, delivery term and the type of delivery. Conclusions. The Apgar disinfectant scale differentiates the results of the indicative questionnaire on motor development research. The results of the study confirm the prognostic importance of the Apgar scale in terms of development.
Physical activity in postmenopausal women
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Szufnara-Wójcik, Gabriela; Boguszewski, Miłosz; Nizio, Norbert; Wyszyńska, Justyna; Drzał-Grabiec, Justyna
Introduction. Menopause is the time when the female body goes through substantial endocrine changes resultant from the gradual phasing out of the reproductive activity of the ovaries. Consequently, post-menopausal women face some perimenopausal symptoms. These symptoms affect everyday physical and psychological functioning to various extent, and result in certain limitations. Aim. The aim of this paper was to study which limitations are most difficult for postmenopausal women, and how menopause symptoms affect women’s physical activity and satisfaction with life, as these are important components of quality of life. Materials and methods. The study involved 60 postmenopausal women. We used our own questionnaire. Results. We did not find the remaining relationships enumerated in research questions: the impact of menopausal syndromes on the frequency of physical activity, on its intensity, and on satisfaction with life, nor with the impact of subjective health on intensity of physical effort. Conclusions. We confirmed the relationship between intensity of physical effort and satisfaction with life and the relationship between subjective assessment of one’s health and the frequency of physical activity.
Inflammatory bowel disease: clinical aspects
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Pasternak, Grzegorz; Aebisher, David; Filip, Rafał; Bartusik-Aebisher, Dorota
Introduction. Inflammatory bowel disease is a complex disease which arises as a result of an interaction between environmental and genetic factors leading to immunological responses and inflammation in the intestine. Aim. To review medical approaches used in inflammatory bowel disorders. Materials and methods. An analysis of literature regarding inflammatory bowel diseases, Leśniowski-Crohn’s disease, ulcerative colitis and mataloproteinases. Results. Current evidence suggests that patients with inflammatory bowel disease may have an elevated risk of endothelial dysfunction and coronary artery disease. Over the past two decades, great advances have been made in our understanding of the interplay between the inflammatory bowel disease. Conclusions. Inflammatory bowel diseases are increasing in Europe. The diagnosis is usually confirmed by biopsies on colonoscopy.
Changes in body proportions of children and adolescents from Rzeszów during a 35-year period from 1978/79–2013/14
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Perenc, Lidia; Radochońska, Anna; Błajda, Joanna
Introduction. Environmental conditions have been changing over the years and the body’s capacity to adapt affects human development, its growth and typogenesis. Aim. To confirm the secular trend in the population of children and adolescents aged 4 to 18 from Rzeszów in the last 35 years in terms of growing and differentiation body proportions. Materials and methods. In 2013/2014, a total of 1,563 children from Rzeszów were examined. The length of the trunk, the upper limb, the lower limb, the width of the shoulders and the width of the hips were measured and the following indices were calculated: trunk length, upper limb length, lower limb length, inter-limb, hip-shoulder and shoulder width. The data was subjected to statistical analysis and compared to the data collected in 1978/79, 1993/1994 and 2003/2004. Results. During the 35-year period, the following symptoms were observed: elongation of upper and lower limbs in both sexes, increase in shoulder width in boys from 15-18 years of age, and in girls generally in the entire examined age, tendency to decrease in hip width in both sexes in most age classes. Conclusions. The secular trend in the population of children and adolescents aged 4 to 18 from Rzeszów in the last 35 years regarding growth process and differentiating body proportions was confirmed.
Receiver operating characteristic analysis of the FeNO biomarker in the diagnosis of asthma
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Biesiadecki, Marek; Galiniak, Sabina; Bartusik-Aebisher, Dorota; Aebisher, David
Introduction. The fraction of exhaled nitric oxide (FeNO) is used as a non-invasive biomarker that reflects inflammation in the airways. It is so versatile that it used to control asthma severity as well as to monitor response to treatment. However, the exact cut-off point of the nitric oxide level which allows one to make a precise diagnosis of asthma is unclear. Aim. To examine the possibility of using advanced statistical methods such as receiver operating characteristic for the analysis of FeNO concentrations for improving the diagnosis of asthma. Materials and methods. Receiver operating characteristic (ROC) was used for analyzing results to determine levels of nitric oxide which may be a prognostic indicator of asthma. The studied group consisted of 111 children including 69 asthmatic patients, and 42 age- and sex-matched healthy subjects. Measurement of exhaled nitric oxide was conducted in all subjects included in this study. Results. FeNO level was higher in asthmatic patients. The analysis of results showed that the cut-off point for the FeNO concentration is 11.5 ppb. Sensitivity and specificity with the FeNO level allowed us to determine a value of the diagnostic variable of FeNO concentration of 14.0 ppb. A comparison of FeNO level and sex of the subjects showed there is no correlation between these parameters of patients. Conclusions. Currently, the FeNO measurement provides complementary data in the care of a patient suffering from asthma, however analysis of more studies on a larger group of patients is needed.
BMI as a factor influencing the number of steps among physical education students
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Herbert, Jarosław; Matłosz, Piotr; Grzywacz, Renata; Jaskierska, Patrycja; Sołek, Aleksander
Introduction. Organized physical activity (PA) is among factors that significantly influence the amount of realized PA. Aim. The aim of this study was to collect and analyze of the influence of BMI on the number of steps among women while undergoing obligatory sport camp as part of physical education studies and during study time at university. Materials and methods. The studies included women (n=60) ranging from 19 to 25 years of age. Their weekly physical activity was monitored using an accelerometer ActiGraph. The significance of the differences between the results for two consecutive measurements are pointed out among the same people, but under different conditions there was assessed at-student test for the variables. Compliance of measurement was described using testing and Bland-Altman chart. For the level of statistical significance p < 0.05 was adopted. Results. The requirements of the WHO on the minimum physical activity were met by almost all students. There is a lack of presence of a statistically significant relationship between BMI and the number of student steps, both in the case of measurement during study time (R = -0.03; p = 0.815) and at camp (R =-0.02; p = 0.865). Conclusions. Women are characterized by high activity (number of steps). BMI does not affect the number of steps for studies. Students meet the requirements of WHO (10000 steps).
The potential of phythotherapy in otorhinolaryngology
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Domka, Wojciech; Aebisher, David; Bober, Zuzanna; Ożóg, Łukasz; Bartusik-Aebisher, Dorota
Introduction. The objective of this paper is to review the evidence of the use of herbs in phytotherapy. Aim. To discuss plant properties and applications in otorhinolaryngology. Materials and methods. We analysed literature and collected information of phythotherapy in otorhinolaryngology. Results. The databases were searched using various keywords such as phytotherapy, otorhinolaryngology, and herbs such as: echinacea, eucalyptus, garlic, ginkgo, ginseng, kava, pelargonium sidoides, rosemary, spirulina, St John’s wort, and thyme. Conclusions. Due to the beneficial impact of meicinal plants in medicine there is a growing interest in analytical identification and quantification for clinical medicine and forensic toxicology.
Multistage treatment of a patient with developmental dysplasia of the hip: A case study
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Cyran-Grzebyk, Barbara; Szczepanik, Magdalena; Majewska, Joanna; Bazarnik-Mucha, Katarzyna; Snela, Sławomir
Introduction. Developmental dysplasia of the hip (DDH) concerns about 5 per cent of the newborn population, and congenital hip dislocation (1%) is considered a challenge in child orthopedics due to the risk of further complications. Recently, the occurrence of this illness has been decreasing due to early hip diagnostics in newborns and fast implementation of proper treatment. Aim. To describe multi-annual treatment and multiplicitous complications in a 15 years old patient diagnosed with DDH. Description of the case. Complications occurring, despite the treatment conducted in accordance with accepted standards, induced the necessity of surgical procedures. This paper describes applied surgical techniques, physiotherapy treatment, the functional status of patient during particular stages of treatment as well as current results of gait analyses. Conclusions. In spite of early diagnosis and treatment of DDH, surgical intervention does not always bring the expected result.
Select aspects of long-term care provision based on opinions of direct informal caregivers
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Czeczelewska, Ewa; Sikora-Mysłek, Irena; Kliś-Kalinowska, Anna
Introduction. The deteriorating health of persons of advanced age necessitates that essential health care services are provided not only by networks of health care institutions but by informal caregivers as well. Aim. The aim of this study was to assess select aspects of care provision for persons requiring long-term care on the basis of opinions shared by their direct informal caregivers. Materials and methods. Surveys were administered to 982 individuals providing informal care for chronically ill persons or for those with disabilities. The survey was conducted in 2017. The questionnaire contained questions concerning the dysfunctions of chronically ill or disabled persons in their daily functioning and addressed related care problems. Results. Over half of the informal caretakers in the study were over 50 years of age (52.5%), had completed secondary educations (45.8%), and lived mainly in cities with populations under 50 thousand (63.4%). Reconciling care-related duties with one’s own professional work or studies was a problem for 43.2% of caregivers. The care tasks which entailed the greatest difficulties for caregivers were washing intimate areas after urination (57.4%) and bowel movements (55.6%) as well as total body bathing. Conclusions. In the opinion of over half of the surveyed caregivers, the activity posing the greatest difficulty for those providing care for persons partially or completely immobilized and possessing physiological dysfunctions (urinary or fecal incontinence) was the washing of intimate areas of the body.
Influence of food-derived advanced glycation end products on health
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Galiniak, Sabina; Biesiadecki, Marek
Introduction. Advanced glycation end products (AGEs) are compounds formed endogenously in the human body. Besides this source of AGEs, they also exist in food and can be generated during cooking. Enhanced endogenous generation and intake of dietary AGEs have physiological impact on human health and are associated with progression of many diseases, including diabetes and its complications. Aim. The purpose of this review is to the present the current state of knowledge about the various negative effects of advanced glycation end products on human health. Materials and methods. This study is based on analysis of literature reporting the content of AGEs in food and high or low AGEs dietary interventions in human and animal subjects. Results. Literature data present databases gathering description of AGEs determinations in various types of food. Conclusions. Excessive consumption of AGEs-rich products, especially abundant in protein and fat or cooked for a long time at high temperature, may contribute to the deterioration of human health, including development of hypertension, insulin resistance, and diabetic complications.

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