European Journal of Clinical and Experimental Medicine T.21, z. 3 (2023)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/9317

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Autoimmune diseases and their various manifestations in the oral cavity – a systematic review
(Publishing Office of the University of Rzeszow, 2023) Lin, Shin-Yi; Huang, Yu-Wei; Błochowiak, Katarzyna
Introduction and aim. Oral manifestation of the disorder is the leading cause of common initial features of most autoimmune diseases. Therefore, this study aimed to present different oral manifestations of selected autoimmune diseases. Material and methods. We systematically reviewed the etiology, signs and symptoms, oral manifestations, epidemiology, diagnosis, treatment plan, and prognosis. We searched the articles on PubMed, Google Scholar and Web of Science for the following search term: Behcet’s disease, lichen planus, mucous membrane pemphigoid and bullous pemphigoid, pemphigus vulgarisms and paraneoplastic pemphigus, rheumatoid arthritis, Sjögren’s syndrome, IgG4-related disease, systemic lupus erythematous, and granulomatosis with polyangitis. Analysis of the literature. We conducted that the disorder’s oral manifestation causes most autoimmune illnesses’ earliest symptoms. Conclusion. Clinical-pathological is a piece of requisite knowledge for the dentist to recognize and diagnose in the early phase of the symptoms.
Factors affecting work-life balance and psychological resilience levels of nurses working in internal clinics during COVID-19
(Publishing Office of the University of Rzeszow, 2023-09) Korkmaz Aslan, Tuba; Burucu, Rukiye; Akdoğan, Yunus
Introduction and aim. COVID-19 intensity has affected both the psychology of the nurses and the balance established between their work and social lives. In this study, it was aimed to examine the work-life balance and psychological resilience levels of nurses. Material and methods. Four Hundred and seventy two nurses, working in various hospitals and internal units in Turkey, voluntarily participated in the study. Data was collected online using the Work-Life Balance Scale, Brief Psychological Resilience Scale, and the Personal Information Form. Results. The sub-dimensions of the work-life balance scale include allocation of time for yourself (β=1.892; p<0.001), life merely being based on work (β=-0.513; p<0.05) and work-life balance; affect the psychological resilience score (β=-0.364; p<0.05). Based on this, devoting time for yourself has a positive effect on psychological resilience, while others have a negative effect. The total score of the nurses on work-life balance is 51.51±7.22 and their psychological resilience score is 15.27±3.93. Conclusion. Psychological resilience is affected by educational status, marital status, having children, and working schedule; work-life balance is affected by educational status, marital status, having children, income levels, and working schedule; while work-life balance sub-dimensions are affected by education, marital status, having children, income levels, place of work and working schedule. Both work-life balance and its sub-dimensions affect the psychological resilience of nurses.
Nutritional knowledge about the Mediterranean diet and its practical application among students in Poland
(Publishing Office of the University of Rzeszow, 2023-09) Karlik, Sandra; Dereń, Katarzyna
Introduction and aim. The popularity of the Mediterranean diet is increasing and following it has many health benefits, including improving mental well-being. The aim of the study was to assess the nutritional knowledge about the Mediterranean diet and its practical application among students in Poland. Material and methods. The study assessed a group of 313 students in Poland. The research tool was a questionnaire that focused on knowledge about the Mediterranean diet. Results. The study showed that in terms of knowledge of the Mediterranean diet, students scored on average 6.5±3.2 points (on a scale 0–11). When it comes to dietary compliance, the average score was 6.3±2.4 points (scale 1–13 points). The better the knowledge of the diet, the better the compliance with its rules. Statistically, the analysis showed that there is a significant relationship between the age and/or academic degree of the students and their higher level of knowledge. The greater compliance with Mediterranean eating patterns was influenced by the location, age, or education of the respondents. Conclusion. The study shows that the surveyed group of students in Poland has only an average level of knowledge and compliance with the Mediterranean diet.
Pathogenesis of selected multiple primary neoplasms
(Publishing Office of the University of Rzeszow, 2023-09) Witek, Marcin Kazimierz; Skrzynecka, Sabina; Bartoszek, Mateusz; Michalik, Julia; Pudźwa, Jakub
Introduction and aim. Multiple primary tumors are defined as having more than one primary tumor in a different organ location in the same person. Therefore, it is important to know pathogenesis of multiple primary neoplasms to discover new forms of primary prevention and secondary prevention, especially connected with genetic tests which are important for the future of medicine as a part of personalized medicine. The aim of the study is to present selected aspects of the pathogenesis of multiple primary neoplasms. Material and methods. PubMed databases and Google Scholar were searched. Analysis of the literature. The rising risk of developing multiple primary cancers is a consequence of the progressive growth and ageing of the population and development of cancer in patients previously treated for cancer. The formation of secondary neoplasms may be multifactorial – to a large extent it is associated with genetic factors that may facilitate neoplastic transformation, for example as a result of radiation therapy, chemotherapy, inherited syndromes, environmental factors such as tobacco or alcohol, sometimes random somatic mutations. Conclusion. Knowledge of the pathogenesis of multiple primary tumors can contribute to a better understanding of the problem, as well as help in the prevention or early diagnosis of multiple primary tumors (primary and secondary prevention).
The difficulties experienced in patient communication by nursing students taking the clinical practice course for the first time – a qualitative study
(Publishing Office of the University of Rzeszow, 2023-09) Harmanci, Pinar
Introduction and aim. Nursing fields begin to face a wide variety of challenges when they first enter clinical practice. The aim of this study is to determine the difficulties experienced in patient communication by nursing students taking the clinical practice course for the first time Material and methods. Focus group interview design was used for this study. Focus group design is used to give information about the opinions and experiences of the sample group on any subject. It is reported as a convenient design to identify different perspectives on a subject within the scope of the sample. Focus group interviews are a widely used method as data collection technique. Results. The findings of the study continue on 4 main themes at level 3, by identifying the similarities and differences in the codes determined by the three experts (researchers consulted and the researcher conducting/reporting the study). The findings of the study were evaluated in comparison with the findings of the studies reached in the literature and conducted in regions such as Israel, Iran, Sri-Lanka, Kenya, and Africa. Conclusion. There are many problems in student-patient communication in many different dimensions. The difficulties arising due to these problems generally focus on unknown clinical environment, lack of knowledge, differences between theory and practice, and mentor interaction.
Analysis of dysarthria in a 55-year-old female patient with multiple sclerosis by means of an IT tool based on respiratory and phonatory examination – a case study
(Publishing Office of the University of Rzeszow, 2023-09) Warmbier, Wojciech A.; Popiel, Małgorzata; Guzik, Agnieszka; Drużbicki, Mariusz; Bartosik-Psujek, Halina
Introduction and aim. There are no available objective tools for assessing dysarthric disorders in the course of multiple sclerosis (MS). The aim of the study is to analyse a case of mixed dysarthria in a 55-year-old female patient in the course of secondary progressive MS and to present the severity of the patient’s dysarthric disorder in contrast with the control group as evaluated by means of an IT tool based on respiratory and phonatory examination. Description of the case. A 55-year-old patient was admitted to the Clinic of Neurology with the Stroke Unit due to a worsening condition in the course of MS. She was examined with an objective tool for respiratory and phonatory disorders. Her results were, then, compared to those of 24 healthy individuals from the control group, matched in terms of sex and age. Following speech parameters were analysed: phonetics of utterances, number of produced syllables per breath during the execution of individual texts, sound quality, intonation, and the total performance time of each. Conclusion. The analysed case indicates that the developed objective IT tool is a promising diagnostic method that can facilitate diagnosis and can be used in clinical practice.
Management challenges and therapeutic strategies for metastatic melanoma – a case report
(Publishing Office of the University of Rzeszow, 2023-09) Aglio, Andrea M.; Cracchiolo, Salvatore; Impellizzeri, Giuseppe; Górecki, Michał
Introduction and aim. This case report focuses on a 26-year-old female with metastatic melanoma. It highlights the diagnostic process, initial immunotherapy, disease progression, and successful response to second-line therapy. Emphasizing the importance of early detection, personalized treatment, and adaptive strategies, it provides valuable insights into managing this aggressive form of skin cancer. Description of the case. A 26-year-old Caucasian female presented with a suspicious pigmented lesion on her thigh in 2013. The lesion was confirmed as superficial skin melanoma. No lymph node biopsy was performed. In 2021, she had abdominal pain and imaging revealed melanoma metastasis in the peritoneum, lungs and brain. Genetic testing showed BRAF V600E mutation and PD-L1 expression in tumor cells. She received immunotherapy and radiation for a central nervous system metastases but developed a brain hematoma. Follow-up imaging showed disease progression. She started second-line therapy with iBRAF/iMEK, and her condition rapidly improved with regression of metastatic lesions. Follow-up imaging confirmed significant positive changes and almost complete regression of neoplastic lesions. She continues to receive the targeted therapy and shows a positive response. Conclusion. Early diagnosis improves outcomes in metastatic melanoma. Peritoneal metastases should be considered in patients with abdominal symptoms. The combination of gamma knife radiosurgery with immunotherapy or targeted therapy shows promise for managing brain metastases, but careful patient selection and monitoring are vital due to potential risks. Treatment responses in advanced melanoma vary, with this case highlighting a favorable response to BRAF/MEK inhibitor therapy in a patient with a BRAF gene mutation. Further research and clinical trials are needed to refine treatment approaches and improve outcomes in metastatic melanoma.
Effectiveness of novel iron regulators in the treatment of diabetic nephropathy
(Publishing Office of the University of Rzeszow, 2023-09) Banerjee, Dekai; Kaur, Ginpreet; Chatterjee, Bappaditya; Joshi, Hemant; Ramniwas, Seema; Tuli, Hardeep Singh
Introduction and aim. The novel advancements of upcoming iron regulators used to treat diabetic nephropathy have implicated a common manifestation of combination chelation therapy used to eliminate end-stage renal disease associated with inflammation and iron imbalance that is altered by renal iron absorption. However, iron accumulation in the clustered kidneys that filter blood may cause problems that affect diabetic blood sugar regulation. Material and methods. A well-designed method was employed to discover relevant research publications on iron chelators and their potential to treat diabetic nephropathy. “Iron chelators”, “diabetic nephropathy”, “end-stage renal disease”, and “chelation therapy” were searched in Google Scholar, Web of Science, PubMed, and EMBASE. Analysis of literature. Although the specific etiology and development have not been fully explored, emerging evidence on iron pathophysiology helps comprehend the pathogenesis of acute kidney damage and chronic kidney disease, which crucially provides novel iron chelation therapy techniques. Ferroptosis and hepcidin marker proteins increase oxidative/nitrifying stress and kidney injury. Iron chelator medicines including deferoxamine, deferasirox, and deferiprone were tested as prophylactic strategies. Conclusion. This article covers both preclinical and clinical aspects of iron chelators to avoid diabetic nephropathy, including novel iron therapies that must be reviewed when selecting dosing regimens.
A study of knowledge attitude practices and identification of perceived barriers towards screening for diabetic retinopathy amongst diabetics in an industrial area in western Maharashtra
(Publishing Office of the University of Rzeszow, 2023-09) Bakare, Prachi; Sethi, Sejal; Mushtaq, Iqra; Maheshgauri, Rupali; Magdum, Renu; Modani, Neha Kamalkishor; Gogate, Parikshit
Introduction and aim. Diabetic retinopathy (DR) screening is first step in prevention of diabetic retinopathy related ocular morbidity. The aim of the study was to assess the gaps in the knowledge and awareness and evaluate its effects on the attitude and practice in known diabetic patients and to assess any anticipated barriers and its association with knowledge, attitude and practices. Material and methods. A closed-ended questionnaire was given to 112 diabetics who met the inclusion criteria and visited a tertiary eye hospital in western Maharashtra. The purpose of the questionnaire was to assess knowledge, attitude and practices and perceived barriers to the study of DR. The statistical analysis was done on SPSS software. Results. In our study, 73.4% did not know about DR, suggesting poor awareness about the disease, 59.5% did not feel the need for regular eye checkup. 67 (61.1%) had no knowledge about blood sugar control level and lipid control for effective control of DR, 89 (79.5%) of participants did not know about effective treatment options. Moreover, 74 (66.1%) participants were advised for DR screening by physician, while 60 (53.5%) were willing to get screened, negative attitude was not getting screened when vision is good seen in 87 (79.1%) participants. Furthermore, 84 (75%) patient think eye checkup are expensive, 66% people believe availability of doctor is an issue. 60 (54.5%) think that eye checkups are time consuming. Conclusion. Our study demonstrated, that Spearman’s correlation coefficient between knowledge and awareness and based on attitude and practice, is 0.54, and that this is statistically significant (p<0.01). Our study has shown poor awareness and knowledge about the disease thus affecting attitude and practices, eye screening is considered expensive has been pointed out a major barrier in this study.
Cancer patients’ attitudes towards holistic complementary and alternative medicine in the management of sleep problems
(Publishing Office of the University of Rzeszow, 2023-09) Baykal, Dilek; Dedeoğlu Demir, Burcu; Yildirim, Dilek
Introduction and aim. Sleep problems are frequently experienced in cancer patients and complementary and alternative medicine (CAM) is solve the problem. However, patients’ attitudes towards this practice are crucial. This study was purpose to investigate the attitudes of cancer patients towards CAM practices in the management of sleep problems. Material and methods. This cross-sectional. and descriptive study was conducted between February-June 2020, on 140 cancer patients in oncology/haematology clinics, three different hospitals in Istanbul. Data were collected by using the Information Form, “Richard Campbell Sleep Questionnaire and The Attitudes towards Holistic Complementary and Alternative Medicine scale”. Results. It was found that the patients had problems with sleep in general 42.74±21.31, mostly in the aspect of the quality of sleep 36.28±26.1. It was determined that stage IV cancer, education and income level of patients affect sleep problems. While female holistic health attitudes were more negative and, their attitudes towards CAM were positive. It was found in the analysis of variance that was performed to determine the difference between the mean scores towards sleep problems of patients in different stages (F=3.062; p<0.05). Conclusion. It was found that cancer patients usually had sleep problems, and their attitudes towards CAM practices were positive.
Evaluation of salivary pH and flow rate among exam going students of Karpaga Vinayaga Institute of Dental Sciences
(Publishing Office of the University of Rzeszow, 2023-09) Perumal, Raghupathy; Balasubramanian, Sasirekha; Subramaniam, Gokulapriya; Krishnan, Ishwariya; Shanmugam, Maheshwari; Santhosh, Kalaiselvi
Introduction and aim. The central nervous systems control salivary pH and Flow; hence it is considered as stress biomarker. To correlate the relationships linking test performance and the cognitive along with affective aspects for the stress of the exams, flow rate and pH levels of saliva. Material and methods. Cross-sectional research was carried out on the day of their final exam and after three months. 90 dental college students provided saliva samples for measuring pH and salivary flow rate. The saliva was collected to measure stress, anxiety, and wellbeing. Results. Salivary flow and pH were increased in the after-exam period. This is mostly due to less threat, stress, and anxiety perception. Conclusion. According to this study, perceived stress can affect salivary flow rate and pH levels, which can be used to gauge the degree of physiological reactions accurately, conveniently, and affordably to tests and variable realistic stresses.
The correlation between nursing students’ levels of fear and stress related to the COVID-19 pandemic and their compliance with standard precautions
(Publishing Office of the University of Rzeszow, 2023-09) Yilmaz Kurt, Fatma; Alankaya, Naile; Atay, Selma; Efil, Sevda
Introduction and aim. University students have been demonstrated in the literature to be a group particularly vulnerable to mental health problems during the COVID-19 pandemic. The aim of this study was to examine the correlation between the fear and anxiety levels of nursing students regarding the COVID-19 pandemic and their compliance with standard precautions. Material and methods. The sample consisted of 509 volunteer students. Data were collected using a Personal Information Form, the Fear of COVID-19 Scale (FCV-19S), the COVID-19 Anxiety Scale (CAS) and the Compliance with Standard Precautions Scale (CSPS). Results. The FCV-19S, CAS, and CSPS mean scores of the students were respectively 17.49±5.24 1.99±3.54 and 13.46±3.61. There was a moderate correlation (p<0.05) between the FCV-19S and CAS of the students, but no correlation was detected between CSPS and FCV-19S (p>0.05) and CAS (p>0.05). Conclusion. It was determined that students had a moderate fear of COVID-19 and a low level of anxiety over COVID-19. However, fear of COVID-19 and COVID-19 anxiety levels were not correlated with compliance with standard precautions.
Morbidity profile and outcome of new-born admitted in sick newborn care units of Uttar Pradesh, India
(Publishing Office of the University of Rzeszow, 2023-09) Singh, Satya Prakash; Paliwal, Harish Chandra; Shekhar, Saket; Kushwaha, Poonam
Introduction and aim. Reduction in child morbidity and mortality is result of upgradation of infrastructure and quality of public health care services. India alone accounts for 30% of the global neonatal deaths occur in India that occurs due to preventable cause. So, the aim of this study was to assess the pattern and status of neonatalmortality observed in SNCUs of Uttar Pradesh, India. Material and methods. Descriptive study was conducted based on secondary data obtained from sick new born care units (SNCU) online database from 89 Government-supported SNCUs of Uttar Pradesh, from April 2014 to March 2016. Data obtained included age, weight, sex, diagnosis, and outcome. Results. 22933 neonates admitted in SNCU were included in study with 14269 (62.2%) were males and 8664 (37.8%) females. Majority of the subject (20070; 87%) were in 0-5 days old age group. Most (72.5%) of admitted new-born improved and discharged. Low birth weight was significantly (χ 2 = 1334.2, p<0.001) related with outcome. Birth asphyxia contributed to maximum (36.11%) number of deaths, followed by respiratory distress syndrome (25.21%), sepsis (15.38%), prematurity and extremely low birth weight (5.8%). Conclusion. Improved antenatal care, improved access to health facility, timely referral of high-risk cases, capacity building, intensive interventional management can reduce neonatal mortality and its complications. Study also warrants, in-depth community-based qualitative study to identify gender-specific, equity issues.
Role of sulfide anion in the development of chronic alcoholic hepatitis under the conditions of modulation of adenosine monophosphate kinase – a correlational study
(Publishing Office of the University of Rzeszow, 2023-09) Mykytenko, Andrii; Akimov, Oleh; Shevchenko, Oleksandr; Neporada, Karine
Introduction and aim. Hydrogen sulfide (H 2 S) has attracted the attention of researchers as a novel signaling molecule that affects vascular metabolism, immune function, stress and inflammation. It plays an important role in pathophysiological disorders under the conditions of the development of obesity, diabetes, non-alcoholic fatty liver disease and cardiovascular diseases. The purpose of this work is to establish correlation ratios of H 2 S concentration with markers of oxidative-nitrosative stress and extracellular matrix metabolism of the liver during chronic alcoholic hepatitis modeling and AMPK modulation by phenformin and doxorubicin. Material and methods. The experiments were performed on 36 white, sexually mature male Wistar rats, weighing 180-220 g. Alcoholic hepatitis was modelled by alcohol administration, on the background of alcoholic hepatitis animals received phenformin orally at a dose of 10 mg/kg or doxorubicin at a dose of 1.25 mg/kg intraperitoneally. Statistical processing of the results of biochemical studies was carried out using the non-parametric method of Spearman to determine correlations. Results. H 2 S during alcoholic hepatitis inversely proportionally strongly correlates with the concentration of nitrites, oxyproline and arginase activity. Phenformin administration during alcoholic hepatitis leads to formation of inversely proportionally strongly correlation of H 2 S with the production of superoxide anion radical, the concentration of malondialdehyde, activities of constitutive NO-synthases, nitrite reductases, nitrate reductases, and arginase. Doxorubicin administration during alcoholic hepatitis leads to formation of directly proportional strongly correlation of H 2 S with the activity of constitutive NO-synthases, nitrite reductases, nitrate reductases. Conclusion. Administration of phenformin or doxorubicin expands correlations between H 2 S and indicators of oxidative-nitrosative stress.
Evaluation of nonpharmacological nursing practices related to thirst and the thirst of patients in the intensive care unit
(Publishing Office of the University of Rzeszow, 2023-09) Çelik, Sevim; Şengül, Münevver; Karahan, Elif
Introduction and aim. Thirst is a significant symptom and stressor among patients in the intensive care unit. The aim of this study is to assess the severity of thirst and associated symptoms experienced by patients in the intensive care unit, and to evaluate the nursing practices related to addressing thirst. Material and methods. This descriptive and correlational study involved a total of 66 patients in the intensive care unit. Severity of thirst experienced by these patients was assessed using a numeric rating scale. The nursing practices related to assessing thirst severity on admission to the unit, on the third day, and on the seventh day were also recorded. Results. Our findings showed a statistically significant increase in the levels of thirst, dry mouth, bad taste and odor in the mouth, as well as sensitivity and dryness in the throat among patients on the seventh day of hospitalization (p<0.05).Among nursing interventions, communication with the patient was the most frequently applied intervention during the seven-day period, with a range of 98.5% to 100%. biochemical control (100%), ventilation of the unit (100%), and temperature regulation (100%) were also frequently applied. Conclusion. The patients had all the symptoms of thirst.The frequency of nursing interventions increased in parallel with the severity of thirst.
The effect of uniform wearing and candle lighting ceremony on nursing students’ perspective on the profession – a qualitative study
(Publishing Office of the University of Rzeszow, 2023-09) Buldan, Özge; Harmanci, Pinar
Introduction and aim. The aim of this study was to investigate the effect of the Uniform Wearing Ceremony and the Candle Lighting on nursing students’ perceptions of the profession. Material and methods. A qualitative, phenomenological method was used to design the study. The standardised criteria for reporting qualitative research with 32 elements were used for the research. The study was conducted with 60 students who volunteered to participate in the study by not selecting a sample of first year nursing students from a university in Northern Turkey. Interviews were conducted 3 times for approximately 20-40 minutes. Results. In this study, the rate of students who perceived the Uniform Wearing Ceremony as positive was as high as (n=42), the rate of those who thought that the uniform had an effect on the image of the nursing profession was 88.3%, and the rate of those who considered nursing as a respected profession was (23%). Conclusion. Nursing students who participated in the study stated that the effect of the Uniform Wearing Ceremony and the Candle Lighting Ceremony positively influenced their perception of the profession and that the uniform had an impact on the image of the nursing profession.
The effect of foot baths on foot pain and leg edema of nursing students during clinical training
(Publishing Office of the University of Rzeszow, 2023-09) Çelik, Sevim; Cerrah, Gülbahar; Gürel, Berşan; Sağlık, Cavide; Albayrak, İrem
Introduction and aim. Edema and pain may occur in the lower extremities due to the long-term standing work of nursing students and the stress they experience. In this study, the aim was to determine the effect of foot baths applied after clinical practice on foot pain and leg edema in nursing students. Material and methods. This randomized controlled study was carried out with second year nursing students. The intervention group received a foot bath (including immersion in water and massage). No intervention was performed on the control group. The data was collected using a survey form, edema follow-up form, visual analog scale, and foot bath equipment. Results. Edema levels in the right tibia decreased statistically on the 1st and 2nd days after the foot bath compared to the values measured after nurses performed clinical practice, while the edema level in the left tibia decreased significantly in the first and fourth weeks (p<0.05). The right and left foot pain scores in the intervention group increased in the evening of the day after the clinical practice compared to before clinical practice, and pain scores decreased statistically significantly after foot bath (p<0.001). The foot pain scores expressed by the students in the first week increased continuously (p<0.001). Conclusion. The study showed that a foot bath performed after clinical practice were effective for easing foot pain and leg edema.
Drug-induced thrombocytopenia – etiology and alternative therapeutic approaches
(Publishing Office of the University of Rzeszow, 2023-09) Rajashekaraiah, Vani; Berikai Ananthakrishna, Anusha
Introduction and aim. The cumulative incidence of drug-induced thrombocytopenia (DIT) is 10 cases per one million people per year with a prevalence of approximately 25% in critically ill patients. This review provides a comprehensive view of drug-induced thrombocytopenia, diagnosis, underlying mechanisms, common strategies in therapeutics, and potential alternatives. Material and methods. Databases such as “Google Scholar”, “PubMed”, “Medline” and “MDPI” was used for literature review with the keywords, “platelets”, “platelet disorders”, “thrombocytopenia”, “drug-induced”, “oxidative stress” “plant extracts”, “phytochemicals”, “antioxidants”, for the articles published between 2013-2023 and written in the English language. Analysis of the literature. Several antimicrobials, anti-cancer drugs, and antivirals are often reported to cause adverse effects during treatment, such as thrombocytopenia. A thorough understanding of the underlying pathophysiology is important for appropriate treatment. Even though an improvement in platelet count is observed after the discontinuation of the causative drug, there is a dire need for treatment in some cases due to associated complications. There are various pitfalls with conventional treatments which include clinical complications and lack of effectiveness. Conclusion. Interventions in therapeutics through antioxidants can aid in faster recovery. Various plant extracts and phytochemicals have been employed as therapeutics in platelet disorders due to their exceptional antioxidant activity. It is imperative to explore the bioactive components of natural products and their influence on platelet efficacy. Also, it highlights how antioxidants can be used as a safe, yet effective option as therapeutics for treating a complicated disorder such as DIT or be used as supplements to prevent adverse effects of existing treatments involving antibiotics and chemotherapeutics.
Effect of meditation on premenstrual syndrome in female medical students
(Publishing Office of the University of Rzeszow, 2023-09) Kaur, Harminder; Kaur, Nimarpreet; Akula, Gangadhar Reddy; Kodidala, Satyanath Reddy
Introduction and aim. A symptom complex of cyclic irritability, depression and lethargy is known as the premenstrual syndrome (PMS). Since ages women suffered from PMS. As varied as the etiology, innumerable treatment modalities have been put forward for PMS. Stress is accompanied most closely associated in PMS. Practicing yoga and meditation significantly important for PMS symptoms in reducing its symptoms and period crams as well. The present study aims the impact of meditation in people with PMS. The aim of the study was to see any effect of Shavasana (meditation) training on stress parameters in premenstrual syndrome in female medical students. Material and methods. The present study was approved by institutional ethical committee. Thirty clinically healthy female medical students who were suffering from PMS selected using a premenstrual questionnaire. The values of heart rate, systolic and diastolic blood pressure, and serum cortisol were measured before meditation. Subjects were then taken through Shavasana (meditation) session for 4 weeks at the same time daily. On the last day of meditation session all above parameters were again recorded and the data was analyzed statistically. Results. The baseline values of all parameters in premeditation session compared to post meditation session. The basal SBP, DBP and HR of female medical students with PMS were significantly higher in pre meditation session than post meditation session with p value of SBP=0.0002, DBP=0.0001, HR<0.0001 respectively which indicated the presence of stress. Following a 4weeks of Shavasana meditation a significant fall in baseline SBP, DBP, HR and the serum Cortisol value was observed. Conclusion. These findings proves that Shavasana is an effective treatment modality to get rid of stress during premenstrual phase.
Hygienic assessment of the occurrence and development of emotional burnout syndrome among medical students and its prevention
(Publishing Office of the University of Rzeszow, 2023-09) Chorna, Valentyna; Syrota, Hanna; Syrota, Mariia; Khliestova, Svitlana; Poliarush, Vlada; Hudzevych, Lyudmyla
Introduction and aim. Emotional burnout syndrome has become increasingly common in recent decades, regardless of the field of professional activity. The purpose of our study was to compare the prevalence of emotional burnout in medical students of Vinnytsia National Medical University before the beginning of the academic semester and during the passing of exams. Material and methods. An anonymous, voluntary survey before the start of study was taken by 300 students, among them 82.3% were women, 17.7% were men. Results. During the exams, 362 students took part, including 76.2% women and 24.1% men. According to the results of the study, the proportion of the “average” degree of exhaustion increased in second-year students by 15.6%; third-year students by 44.4%. The “high” degree of emotional exhaustion according to the results of the study before the start of training was found in male students of the third year – 44.4% and 36.4% of male students of the sixth year. During the exams, the rate of “high” emotional exhaustion was observed in first-year students, increasing from 12.5% to 18% and in sixth-year students from 36.4% to 50%. Conclusion. Thus, it was found that female students are the most adapted to the educational load, to passing exams, which affects the psychosomatic state of future doctors.

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Przeglądanie European Journal of Clinical and Experimental Medicine T.21, z. 3 (2023) według Data wydania