European Journal of Clinical and Experimental Medicine T.22, z. 2 (2024)

URI dla tej Kolekcjihttps://repozytorium.ur.edu.pl/handle/item/10593

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Survival outcome and prognostic factors in patients with chemotherapy-naive metastatic castration-resistant prostate cancer treated with abiraterone acetate – real-world experience in Vietnam
(Publishing Office of the University of Rzeszow, 2024-06) Do, Tu Anh; Nguyen, Thai Hoa Thi; Nguyen, Hau Xuan; Nguyen, Loi Dinh; Nguyen, Chu Van
Introduction and aim. In real life, metastatic castration-resistant prostate cancer patients (mCRPC) had more complex clinical presentation than patients in the COU-AA-302 trial. This study primarily aimed to describe the overall survival of chemotherapy-naive mCRPC treated with abiraterone acetate plus prednisone (AAP). Other relevant outcomes and baseline characteristics of these patients were also evaluated. Material and methods. This retrospective, observational study collected data from chemotherapy-naive mCRPC patients treated with AAP in Vietnam. Kaplan-Meier curves were used to estimate time to treatment failure (TTF), and overall survival (OS). The impact of baseline characteristics on OS was explored using univariate and multivariate Cox proportional hazard models. Results. Data from 65 eligible patients were analyzed. The rate of PSA response was 73.8%, median PSA PFS was 10.5 months (95% CI: 7.4–13.6), median TTF was 15 months (95% CI: 11.1–18.9), and median OS was 24.9 months (95% CI: 18.9–30.9). Shorter OS was significantly associated with a higher Gleason score (≥8), shorter time from ADT start to mCRPC (<12 months), visceral metastases, and <50% PSA decline (p<0.05). Conclusion. Abiraterone acetate plus prednisone is well tolerated and effective for chemotherapy-naive mCRPC patients in clinical practice. Moreover, Gleason score, visceral metastasis, time from ADT start to mCRPC, and PSA response are the independent indicators for predicting the OS of mCRPC patients in both univariate and multivariate analyses.
Inference of oxidative stress in patients with hypothyroidism
(Publishing Office of the University of Rzeszow, 2024-06) Rada, Feryal
Introduction and aim. Oxidative stress is one of the complications that accompany defects in thyroid hormone levels. This study was designed to evaluate oxidative stress markers in patients with hypothyroidism. Material and methods. This case control study was comprised of forty-two hypothyroid patients aged 36–46 years and forty age matched (35–43 years) healthy control participants randomly selected from the Endocrine Clinic of Al-Yarmook Hospital in Iraq. Blood levels of thyroid hormones malondialdehyde, glutathione, and paraoxonase-1 were assessed. Body mass index was calculated for each patient and control participant. Results. Regarding the data of oxidative stress markers in hypothyroid patients compared to controls, a significant elevation was reported in blood levels of malondialdehyde and a significant reduction was found in blood levels of glutathione (p=0.031). On the other hand, the blood levels of paraoxonase-1 were significantly different in hypothyroid patients compared with the control. Conclusion. Elevated blood levels of malondialdehyde and declined blood levels of glutathione in hypothyroid patients are a signal of oxidative stress and consequently increase the risk of cardiovascular complications.
The prevalence of incidental findings in computed tomography of the head in Pediatric Emergency Department
(Publishing Office of the University of Rzeszow, 2024-06) Lipińska, Justyna; Lipiński, Łukasz; Kopeć, Izabela; Kowalczuk, Maria; Woźniak, Magdalena Maria
Introduction and aim. Computed tomography (CT) is the first imaging modality in the evaluation of children in case of patients with head injury in pediatric Emergency Departments (EDs). Radiological CT reports include not only lesions that are the main cause of the child’s complaints but also incidental findings. The objective of this study is to assess incidental findings observed in children who were admitted to the ED and had the head CT performed. Material and methods. This retrospective, cross-sectional study enrolled 644 children under the age of 18, from 1st January 2021 to 31st June 2021. Each child could have had one or more incidental findings in CT Results. Among all CT studies, incidental findings were found in 279 out of 644 (43.32%) cases, of which 73 (11.34%) had both lesions detected incidentally and related to the trauma. Conclusion. Head CT is an incredibly useful tool in the assessment of some head emergencies. However, evaluation of the prevalence of incidental findings is difficult. Most of them require no specific further investigation. Pediatricians, who order CTs in children, must be prepared to interpret and communicate findings to families and introduce treatment in necessary situations.
The relationship between knowledge levels of HPV and health literacy in youth – an example from Türkiye
(Publishing Office of the University of Rzeszow, 2024-06) Şen, Mehmet Ali; Yakıt Ak, Eda
Introduction and aim. Human papillomavirus (HPV) is a common infection responsible for many cancers. This study was conducted to determine the relationship between the knowledge level of HPV and the health literacy of youth living in Türkiye. Material and methods. The study sample comprised 543 youth aged 18 and 30 living in Türkiye. The data were assessed with a questionnaire, the human papilloma virus knowledge scale (HPV-KS), and the health literacy scale (HLS) and the correlation between them. Results. 50.6% of the youth informed that they are aware of HPV, and 54% of the youth know about the transmission mode of HPV. It was determined that knowing HPV increased 1.839 times by being a woman, 1.949 times by being married, and 14.339 times by knowing STIs. The HPV-KS total score average of the youth was low at 14.26±7.04, and the total score average of HLS was high at 107.91±16.81. A positive and significant correlation was found between HPV-KS total score, all sub-factor scores, HLS total score, and all sub-factors total score (p<0.001). Conclusion. Information studies on HPV should be increased by taking advantage of the generality of health literacy.
Characteristics of patients with cerebral aneurysms and arteriovenous malformations
(Publishing Office of the University of Rzeszow, 2024-06) Ożga, Joanna; Skiba, Marcin; Sztuczka, Szymon; Wyka, Michał
Introduction and aim. Aneurysms and arteriovenous malformations (AVMs) are both vascular abnormalities that can occur simultaneously or separately and increase the risk of intracerebral hemorrhage. The aim of this research was to characterize patients with intracranial aneurysms and AVMs. Material and methods. This retrospective research was based on analysis of Digital Subtraction Angiography. The research group consisted of 118 patients. StatSoft STATISTICA 13 was used for the statistical analysis of parameters, such as dimensions and vascularization pattern of vascular abnormalities. Results. The total number of aneurysms described was 168. In addition, 33 patients with cerebral aneurysms were also diagnosed with cerebral AVMs. The average dimensions of the aneurysms were 6.33mm, 95% CI (5.47 7.18) × 4.76mm, 95% CI (4.09, 5.43). The abnormalities were found in the extent of circulation of ACA (anterior cerebral artery) 50 (29.76%), ICA (internal carotid artery) 48 (28.57%), MCA (middle cerebral artery) 26 (15.48%), PCA (posterior cerebral artery) 23 (13.69%). There were 76 (64%) patients with diagnosed single aneurysms and 42 (36%) with multiple. Conclusion. Aneurysms are more likely to occur singly than multiply. The majority are located within the vascularization of the ACA. Aneurysms can coexist with AVMs, which increases the risk of rupture.
Encapsulation of genistein in glycidylated G3 polyamidoamine dendrimers enables diffusion of genistein through biological membranes and anti-nematode activity of the encapsulate
(Publishing Office of the University of Rzeszow, 2024-06) Filipowicz-Rachwał, Aleksandra; Drozdowska, Joanna; Zagórska-Dziok, Martyna; Uram, Łukasz; Wołowiec, Stanisław
Introduction and aim. Poorly soluble isoflavonoid genistein is known as an anti-nematode agent and also it decreases the risk of certain types of cancer. The biological activity of genistein is limited mostly by its low solubility. Therefore many attempts to increase genistein solubility in water were reported. We applied a polyamidoamine dendrimer, modified its surface by glycidylation, and used this macromolecule as a guest for genistein. Material and methods. Polyamidoamine dendrimer 3rd generation was substituted with 64 glycidol residues to obtain a macromolecule host for genistein. The stoichiometry of this host-guest complex was determined. The complex was tested for skin model permeability, toxicity on fibroblast (BJ) and keratinocyte (HaCaT) cell lines in vitro and anthelmintic activity on the Caenorhabditis elegans nematode. Results. The partition coefficient of genistein between octanol and water was determined (KO/W). The 1:1 host-guest complex was isolated and used as drug delivery system for genistein delivery. PAMAM G3 glycidyled dendrimer containing genistein indicated an anthelmintic activity at 50 µM concentration. Conclusion. The solubility of genistein in water increases 640 times in presence of an equimolar concentration of the dendrimer. One molecule of host dendrimer encapsulates 3 molecules of genistein. The encapsulate is an efficient anti-nematode formulation.
Effectiveness of health education on knowledge, attitude and practice regarding junk food consumption among interns in a tertiary health care center in Chennai, India – a quasi-experimental study
(Publishing Office of the University of Rzeszow, 2024-06) Mary, Bella; Murugan, Arun; Ramasubramanian, Ramachandran; Kamali, Ravinder; Ragavan, Mohanakrishnan Uppili Venkat; Sathishkumar, Kasinathan
Introduction and aim. Junk foods are defined as any of various pre-packaged foods that are high in calories but low in nutritional value. This study was done to evaluate the effect of health education intervention on the knowledge, attitude, and practices regarding junk food consumption among MBBS interns at the tertiary health care center in Chennai, India. Material and methods. This was a quasi-experimental study conducted from January to March 2023 among 105 CRMIs of a Government medical college in Chennai, India. After getting Institutional Ethics Committee approval, data was collected using a pretested self-administered semi structured questionnaire before and after health education intervention. Results. The majority (55.2%) of the respondent interns were hostellers. There was a significant increase in the knowledge (p<0.001), healthy attitude (p<0.001), and healthy practice (p<0.001) concerning junk food intake following health education intervention. Conclusion. Routine repeated sessions promoting health should be implemented in the medical curriculum in order for our future physicians to live a long healthy life as well as to set a good example
Relationship between perceived fear of COVID-19 and self-care management in heart failure patients
(Publishing Office of the University of Rzeszow, 2024-06) Yeni, Tuğba; Bülbül, Elif; Efil, Sevda; Yıldız-Ayvaz, Meryem; Türen, Sevda; Hiçerimez, Ayfer
Introduction and aim. The fear of contracting COVID-19, which affects human health biopsychosocially, is expected to affect the self-care management of patients with heart failure (HF). This study was conducted to investigate the relationship between perceived fear of COVID-19 and self-care management in HF patients. Material and methods. The study was conducted with 115 HF patients. “Sociodemographic characteristics form”, “Fear of COVID-19 tool” and “Nine-item European Heart Failure Self-care Behavior Scale (EHFScB Scale-9)” were used to collect data. Results. 51.3% of the participants in the study are in the 40–60 age range, 53.7% are male, 92.2% live with their family, 64.3% have a diagnosis of HF for less than 5 years. Levels of COVID-19 fear, and self-care management were found to be high in the participants who are 40 years old or younger, has higher education level, diagnosed within 1 to 3 years, received psychological support during the pandemic process, received training from doctor or nurse about COVID-19. Fear level and self-care levels were moderately positively correlated. Conclusion. During the COVID-19 pandemic, it is necessary to develop effective care strategies to identify individuals with diseases such as HF who should have high self-care management skills.
Evaluation of the knowledge, attitudes and behavior of healthcare workers concerning influenza vaccination in a training and research hospital in Türkiye
(Publishing Office of the University of Rzeszow, 2024-06) Apaydin, Mehmet; Dogan, Serap; Aypak, Cenk
Introduction and aim. Although increasing vaccination rates among healthcare workers (HCWs) is crucial for protecting their own health and preventing the spread of infections to patients, vaccination rates remain low. The purpose of this study is to evaluate the knowledge, attitudes, and behavior of healthcare workers concerning seasonal influenza vaccination in a training and research hospital in Türkiye. Material and methods. This cross-sectional descriptive study was conducted among 364 healthcare workers working in a training and research hospital in Ankara, Türkiye. A face-to-face questionnaire was completed by selected participants that included questions about their sociodemographic characteristics, receiving seasonal influenza vaccination, reasons for not receiving vaccination, attitudes and behavior towards seasonal influenza vaccination recommendations for their surroundings, knowledge of who should get the vaccine, and their immunization history. Results. Among the participants, 58.5% stated that they had never received an influenza vaccination, 35.7% mentioned not receiving the regular influenza vaccination, and only 5.8% reported receiving the influenza vaccination regularly every year. Reasons for not getting vaccinated included not trusting the influenza vaccine’s protection (60.1%), not believing they are in the risk group (38.9%), and not finding a suitable time to get vaccinated (36.1%). A total of 57.1% of the healthcare workers recommended the influenza vaccine for their surroundings. Conclusion. Influenza vaccination rates among healthcare workers are quite low. To maximize influenza vaccine uptake, awareness programs are needed to correct the misconceptions health care workers have about the vaccine, and diverse strategies should be implemented to encourage them to get vaccinated, thereby promoting influenza vaccination.
Turkish cross-cultural adaptation of Pediatric Transition Experience Measure
(Publishing Office of the University of Rzeszow, 2024-06) Kurt, Aylin; Dinç, Fatma; Şan, Emine Güneş
Introduction and aim. The period immediately after leaving the hospital is known as the transition home, which presents a critical time for parents to take on all the responsibilities and care of a child without the support of the hospital environment. The purpose of this study is to culturally adapt the Pediatric Transition Experience Measure (P-TEM) instrument into Turkish and test its validity and reliability. Material and methods. We conducted this methodological study with parents of children who were discharged from the hospital between May 2021 and May 2022. We evaluated linguistic, content, construct, convergent validity, and internal consistency. Results. The P-TEM exhibited a two-factor structure and accounted for 65% of the overall variability. The internal consistency reliability for the transition preparation and transition support subdimensions was 0.779 and 0.793, respectively, while the total measure had a reliability of 0.831. The item-total correlations for the P-TEM ranged from 0.493 to 0.671. Parents who received the highest P-TEM scores experienced a 5.1-point improvement (95% confidence interval: 1.7 to 8.6) in their satisfaction with healthcare services, which was greater than that of parents who reported lower P-TEM scores. Conclusion. It is worth noting that the P-TEM has been validated and has high reliability in Türkiye.
Prognostic significance of C-reactive protein/albumin and neutrophil/lymphocyte ratios in patients with COVID-19
(Publishing Office of the University of Rzeszow, 2024-06) Polat, Hatice Beyazal; Arpa, Medeni; Polat, Zehra; Beyazal, Mehmet; Çelike, Fatma Beyazal; Ayaz, Teslime; Ertürk, Ayşe
Introduction and aim. COVID-19 causes an uncontrolled and generalized inflammatory response of the host immune system. Early recognition of the disease and early prediction of the clinical course are of great importance. The aim of this study was to evaluate the predictive role of the C-reactive protein/albumin ratio (CAR) and the neutrophil/lymphocyte ratio (NLR) for mortality in patients hospitalized with the diagnosis of COVID-19. Material and methods. The patients, who were hospitalized for COVID-19 and whose CRP, albumin, neutrophil, and lymphocyte levels were documented within the first 24 hours after admission, were analyzed retrospectively. Patients were divided into survivors and non-survivors; the groups were compared. Univariate and multivariate Cox regression models were developed to evaluate the CAR and the NLR as risk factors for mortality in COVID-19 patients. Results. One hundred and thirty patients were included in this study. The mean age of the survivor group (n=114) was 60±16 and 52% were male. The mean age of the non-survivor group (n=16) was 75±13 and 56% were male. In the non-survivor group, the CAR detected at the time of admission to the hospital was significantly higher compared to patients in the survivor group (p=0.026). Conclusion. As a result, the CAR, the NLR and LDH are independent risk factor indicators of mortality in hospitalized patients
Comparative study of pterygium excision with suture and sutureless conjunctival autograft
(Publishing Office of the University of Rzeszow, 2024-06) Khandelwal, Richa; Tigga, Mary Jenifa; Metri, Rajashekar; Deshpande, Anand; Tarun
Introduction and aim. This is a prospective interventional study to compare corneal astigmatism before and after pterygium excision with conjunctival autograft, to determine the difference in mean corneal curvatures before and after pterygium excision, to evaluate the safety and efficacy of autologous blood technique, and sutured conjunctival autograft for primary pterygium. Material and methods. Patients were divided into group A – pterygium excision+sutured conjunctival limbal autograft and group B – pterygium excision+autologous conjunctival limbal autograft under local anesthesia. The preoperative and post operative K1 and K2 values and BCVA were noted. Results. There was statistically significant reduction in mean astigmatism at each post operative follow up in group A at 1 week (p=0.0249), 2 weeks (p=0.004), 1 month (p=0.0031) and at 3 months (p=0.0009) and similarly in group B post operative follow up at 1 week (p=0.0011), 2 weeks (p=0.0021), 1 month (p=0.0009) and at 3 months (p=0.0003). Conclusion. Pterygium surgery decreases the cylindrical error and reverts corneal curvatures to normal, thus improving subjective visual acuity. Astigmatism produced by the pterygium is reduced after surgery We found autologous conjunctival autograft is superior than sutural conjunctival autograft. Pterygium causes astigmatism depending upon the size of pterygium it should be surgically removed to prevent obstruction in the vision.
The effect of thiocetam on the parameters of the nitric oxide system under the conditions of the experimental periodontitis and immobilization stress formation
(Publishing Office of the University of Rzeszow, 2024-06) Regeda, Mykhailo; Olekshij, Petro; Regeda-Furdychko, Maaryana; Furdychko, Lubomur; Kolishetska, Marta; Regeda, Stepan; Fil, Vitalii
Introduction and aim. The aim of this work is to study the parameters of the nitric oxide (NO) system in the blood of guinea pigs under the conditions of the experimental periodontitis (EP) and immobilization stress (IS) formation and to evaluate the effectiveness of thiocetam use. Material and methods. Experimental studies were performed on 50 guinea pigs (males, body weight 0.18–0.21 kg) which were divided into five groups (10 in each): the first group were intact animals as control; the second experimental group were animals with experimental periodontitis under conditions of immobilization stress (3rd day), the third group included guinea pigs with EP and IS on the 5th day of the combined model process, group IV – animals with EP and IS 15th day (without administration of thiocetam) and group V – animals on the 15th day of experiment with EP and IS after use of thiocetam. Results. As a result of this research, changes in the activity of the NO system in the blood were observed, namely an increase in the level of stable metabolites and an increase in the activity of total NO-synthase, which is accompanied by a compensatory inhibition of the L-arginine activity, and these indicators were most pronounced in the late stages of EP and IS formation. Conclusion. The use of thiocetam showed a corrective effect on the changed variables of NO metabolism in the peripheral blood of guinea pigs under the conditions of the EP and IS development.
ChatGPT in hospital infection prevention and control – assessing knowledge of an AI model based on a validated questionnaire
(Publishing Office of the University of Rzeszow, 2024-06) Jawanpuria, Ankita; Behera, Aruna Rani; Dash, Chinmaya; Rahman, Mohammad Hifz Ur
Introduction and aim. An AI model like ChatGPT is a good source of knowledge. We can explore the potential of AI models to complement the expertise of healthcare professionals by providing real-time, evidence-based information in infection prevention and control (IPC). Material and methods. This study involved 110 queries related to IPC, validated by subject experts in IPC. The responses from ChatGPT were evaluated using Bloom’s taxonomy by experienced microbiologists. The scores were divided as 4 as a good response. Statistical analysis was done by correlation coefficient and Cohen’s Kappa. Results. The overall score was 4.33 (95% CI, q1 3.65–q3 4.64) indicating ChatGPT’s substantial IPC knowledge. A good response (i.e.>4 score) was found in 70 (63.6%) questions, while in 10 (9%) questions, it showed a poor response. The poor response was seen in needle stick injury and personal protective equipment (PPE) doffing-related questions. The overall correlations were found to be significant. Cohen’s Kappa confirmed moderate to substantial agreement between evaluators. Conclusion. ChatGPT demonstrated a commendable understanding of IPC principles in various domains and the study identifies specific instances where the model may require further refinement especially in critical scenarios such as needlestick injuries and PPE doffing.
Gifted children and their peers perceived parental attitudes, psychosocial problems and quality of life
(Publishing Office of the University of Rzeszow, 2024-06) Yildiz, Sümeyye; Altay, Naime
Introduction and aim. Gifted children are defined as extraordinary children due to their high level of intelligence and specific skills. This study aimed to examine gifted children and their peers perceived parental attitudes, quality of life (QoL), and psychosocial problems. Material and methods. The study sample consisted of two groups: (1) gifted children (study group) and their parents and (2) peers (control group) and their parents. Data were collected using a descriptive characteristics form, the parental attitude scale (PAS), the pictorial pediatric symptom checklist (PPSC) and the pediatric quality of life inventory (PedsQL). Results. Both groups were similar in terms of age, gender and grade level. It was mostly the mothers who completed the data collection forms. The study and control groups had a mean PAS score of 94.18±0.738 and 99.31±0.798, respectively and a mean PPSC score of 16.11±0.475 and 16.76±0.480, respectively. The study and control groups had a mean QLS score of 83.19±0.70 and 80.28±0.83, respectively. There was a weak positive correlation between the PAS and PPSC scores (r=0.92; p<0.166). Conclusion. It is recommended that parental attitudes and their effects on children’s psychosocial status and QoL be monitored and that parents be supported. Parental attitudes and a child’s psychosocial and behavioral problems and QoL levels should be assessed to by health professionals be able to improve the well-being of both children and their parents.
The relationship between psychological well-being with levels of anxiety, COVID-19 fear and depression in individuals hospitalized with COVID-19
(Publishing Office of the University of Rzeszow, 2024-06) Düzgün, Nurcan; Çoban, Sibel Arguvanli; Kaya, Özlem Bolat
Introduction and aim. The COVID-19 pandemic negatively affected both the physical and mental health of societies. The present study was conducted to determine the relationship between psychological well-being with levels of anxiety, COVID-19 fear, and depression in individuals hospitalized with COVID-19. Material and methods. This descriptive correlative study was conducted with 685 individuals diagnosed with COVID-19 treated in the clinics of a pandemic hospital. The data of the study were collected with the information form, psychological well-being scale (PWBS), COVID-19 fear scale (FCV-19S), and hospital anxiety and depression scale (HADS). Results. The mean PWBS score of the participants was 37.21±14.3, the FCV-19S score was 20.10±10.41, the HADS-anxiety score was 9.07±7.29, and the depression score was 10.74±7.35. The PWBS scores with FCV-19S scores of the participants, HADS-anxiety, and HADS-depression scores were found to be negatively correlated (p<0.001). Conclusion. In conclusion, as the anxiety, fear, and depression levels experienced by individuals receiving inpatient treatment in a pandemic hospital due to COVID-19 increase, their psychological well-being levels decrease at a statistically significant level. It may be recommended to intervene in the anxiety, fear, and depressive symptoms of individuals receiving inpatient treatment due to a diagnosis of COVID-19 to increase their psychological well-being.
A study of etiological spectrum in 106 cases of pancytopenia
(Publishing Office of the University of Rzeszow, 2024-06) Singhal, Parul; Mittal, Adreena; Dixit, Ritvija
Introduction and aim. Pancytopenia is the simultaneous presence of anemia, leucopenia and thrombocytopenia. The aim of this work was to study the etiological spectrum of pancytopenia in the National capital region of India, and evaluate the relationship of pancytopenia with serum vitamin B12 levels. Material and methods. This study is of a prospective and analytical type conducted on patients attending the outpatient and inpatient department of Santosh Medical College and the Saraswathi Institute of Medical Sciences tertiary care centers in NCR. Complete blood counts and peripheral blood smear examination was used for morphological classification and typing of anemia. Bone marrow aspiration and vitamin B12 estimation was performed where required. Results. The maximum number of pancytopenia cases were etiologically attributed to megaloblastic anemia (64.2%) followed by aplastic anemia (19.8%). Malaria was attributed to 6.6% cases of pancytopenia. Iron deficiency anemia and tuberculosis both accounted for 1.9% of cases. each. A history of drug intake and mixed nutritional anemia each contributed to 2.8% of cases. Serum vitamin B12 levels showed a significant relationship with pancytopenic cases. Conclusion. In our study, the main cause of pancytopenia is megaloblastic anemia which responds very well to treatment if diagnosed correctly in time. A detailed hematological assessment along with vitamin B12 levels should be evaluated in all cases of pancytopenia irrespective of the etiological categorization.
Synthesis, characterization of isoxazole derivatives and evaluation of their antibacterial, antioxidant and anticancer activity
(Publishing Office of the University of Rzeszow, 2024-06) Vashisht, Ketan; Sethi, Pooja; Bansal, Anshul; Singh, Tejveer; Kumar, Raman; Tuli, Hardeep Singh; Saini, Shallu
Introduction and aim. The synthesis of heterocyclic compounds containing oxygen and nitrogen is profoundly intriguing due to their mechanistic implications in both research and development within organic chemistry and drug discovery. The primary aim of this study is to fabricate a range of pharmacologically active drugs containing the isoxazole moiety. Material and methods. The synthesis of new derivatives of isoxazole was achieved through a one-pot condensation reaction of 2-[(Substituted phenyl)hydrazono]malononitrile (1) and 3-[(Substituted phenyl)azo]-2,4-Pentanedione (2) with sodium acetate and hydroxylamine hydrochloride (1:1) in ethanol. All the compounds were screened for their in vitro antibacterial activity, in vitro antioxidant and anticancer activity. The synthesized compounds underwent characterization through FTIR, 1 H NMR, and 13C NMR analyses, supported by mass spectral data and elemental analysis. Results. A set of novel isoxazole derivatives was synthesized with a favorable yield. Among compounds 1d, 1e, 2c, 2d, and 2e exhibited notable antioxidant activities. Compounds 1a, 1b, and 1c demonstrated significant anticancer potential against prostate cancer [PC3] cell lines compared to normal HEK cell lines, while 2a displayed the highest inhibitory zone against Escherichia coli. Conclusion. Novel compounds with multifaceted biological activities have been successfully designed, and a synthetic route to create isoxazole derivatives has been devised and verified.
Knowledge of esophageal cancer and preventive behaviors among nursing students – a cross-sectional study
(Publishing Office of the University of Rzeszow, 2024-06) Cevik, Ayfer Bayindir; Andsoy, Işıl Işık; Yıldız, Hicran
Introduction and aim. There is a gap in nursing student understanding, knowledge, and preventive behaviors concerning esophageal cancer. This study aimed to investigate knowledge, risk factors, and preventive behaviors among Turkish nursing students. Material and methods. A descriptive cross-sectional survey was performed. The questionnaire was conducted online over a four-month period. A convenience sample of 688 undergraduate nursing students was recruited from health science faculty at three universities in Türkiye. The survey was performed using a self-administered questionnaire. The reliability coefficients of the knowledge test were calculated, yielding Cronbach’s alpha (0.952), KR-20 (0.952), and KR-21 (0.945), respectively. A significance level p<0.05 was accepted. Results. The mean age of the study group was 20±1.86 (min: 17, max: 32). The study group consists of 487 women (70.8%) and 201 men (29.2%). Most of the study population report never using alcohol and smoking (88.4%, 73.1%, respectively), and reported paying attention to oral hygiene (88.5%). Nursing students had a low family history of EC (0.4%), obesity (10.2%), and vitamin deficiency (19.2%) which are risk factors. Knowledge of esophageal cancer risks was low (x̄=14.34±9.53; Min=0; Max=31). Total knowledge scores have higher for students with complaints of EC, vitamin deficiency, and diagnosis of Human Papilloma Virus disease (p<0.05). Conclusion. This study showed that there are significant gaps in the knowledge of nursing students and these need to be addressed through an improved nursing curriculum. In this context, the study can be used as important evidence and a resource in the issues that should be given priority to in the training and research needed to increase the knowledge and awareness of future nurses about esophageal cancer.
Brazilians living with diabetes do not meet basic physical activity guidelines for health – a cross-sectional study
(Publishing Office of the University of Rzeszow, 2024-06) de Lima, Dartel Ferrari; Lima, Lohran Anguera; de Souza, Dayane Cristina; Sampaio, Adelar Aparecido; Machado, Daiana
Introduction and aim. The purpose of this study was to describe the profile of physical activity (PA) of Brazilian adults living with diabetes mellitus living in large Brazilian urban centers, as well as to determine whether the practice aligns with the physical activity guidelines recommended for people with diabetes. Material and methods. Cross-sectional data were acquired from the 2020 Surveillance System for Risk and Protective Factors for Chronic Non-communicable Diseases, in which about 54,000 persons aged 18 and older in all Brazilian state capitals were contacted in a telephone survey. Participants reported on their engagement in recreational physical activity and active commuting to school and/or work in the three months preceding the interview, as well as the weekly frequency and duration of these activities. They also stated whether they were living with diabetes. A descriptive analysis was performed, and statistical significance was determined using Pearson’s chi-squared test. Results. In 2020, 7.9% of the population identified themselves living with diabetes. There was a greater frequency among older women and those with less education. Walking, water aerobics, and general gymnastics were the most common kinds of physical activity reported by people with diabetes. Moreover, over half of them (54.5%) were inactive, and 15% matched the physical activity criteria. The majority (90%) practiced PA for 30 minutes or more per day, while 87% of those who were active and exercised 1 to 2 times per week did not meet the requirements of the Ministry of Health. Conclusion. In 2020, 7.9% of the population identified themselves as having diabetes. There was a higher frequency among older women and those with less schooling. In the sample as a whole, approximately 70% of people living with diabetes were inactive (54.5%) or did not meet the minimum BP recommendations for people with diabetes. The duration of each session seemed to be in line with the recommendations, however, the lack of regularity caused by the low weekly frequency meant that the minimum recommended target could not be achieved. Efforts involving the continued monitoring of people living with diabetes and counseling in Primary Health Care to opt for a more physically active life, seem to be promising acts for a healthier life, pending a definitive resolution to the disease.

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Przeglądanie European Journal of Clinical and Experimental Medicine T.22, z. 2 (2024) według Data dodania