European Journal of Clinical and Experimental Medicine T.16, z. 2 (2018)

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Influence of Adriblastin and Bleomycin on Wistar rat mothers and fetus development
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Sęk-Mastej, Anna; Galiniak, Sabina; Krawczyk-Marć, Izabela; Balawender, Krzysztof; Szymczak, Artur; Kaniewski, Maciej; Leksa, Natalia; Biesiadecki, Marek; Orkisz, Stanisław
Introduction. Gestation is a very sensitive time both to mother and child. Any substance, factor, or environmental condition disturbing homeostasis may cause congenital defects, anomalies or even death. Teratology evaluates those potential factors and their influence. Also, medicinal products used during pregnancy may be teratogenic. Adriblastin, also known as Doxorubicin, and Bleomycin are widely used cytostatic drugs in oncology. Aim. Aim of this study was to evaluate the embryotoxic effects of Doxorubicin and Bleomycin in an animal model. Materials and methods. Fertilised Wistar rat females were given each drug intraperitoneally between the 8th and 15th gestation day, and compared to control group receiving placebo (distilled water, 0.9% NaCl). Another group received acetyl salicylic acid, as a model, well known teratogen. Changes in mothers’ weight from baseline, implantation of embryos, any discrepancies in mothers wombs and health as well as defects in fetuses were evaluated and compared. Fetus skeletons were stained by Dowson’s method to visualise bone defects. Results and conclusion. Both Adriblastin and Bleomycin were teratogenic, producing significantly more embryo absorptions, and fetal defects compared to placebo. The effects of the two cytostatics were similar to the model teratogen acetyl salicylic acid.
Retrospective analysis of reactive hyperplastic lesions in the oral cavity
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Farynowska, Justyna; Błochowiak, Katarzyna; Trzybulska, Dorota; Wyganowska-Świątkowska, Marzena
Introduction. Reactive hyperplastic lesions of the oral cavity are non-neoplastic lesions that result from low-grade chronic irritation of the oral mucosa. Objectives. The aim of this study was to present the epidemiological characteristics of reactive lesions. Materials and methods. The study was a retrospective analysis of the medical records of 116 patients with reactive lesions. The tissue specimens were obtained by biopsy. 115 patients underwent an excisional biopsy, whereas in one case an incisional biopsy was performed. Results. The most frequently encountered lesion was inflammatory fibrous hyperplasia (IFH) (n=37, 31.9%), followed by irritation fibroma (IF) (n=36, 31%), pyogenic granuloma (PG) (n=15, 12.9%), fissured granuloma (FG) (n= 14, 12.1%). The lesions were more commonly observed in females (n=70, 60.3%) than in males (n=46, 39.7%) with a ratio of 1.5:1, respectively. The buccal and labial mucosa were the most prevalent sites of reactive lesions. Most of the lesions were between >5 mm and ≤10 mm in diameter except for FGs, which were much bigger. Conclusions. Early detection and elimination of all potentially causative factors and irritants is a crucial matter, especially in the case of the vestibule of the oral cavity, which is the most susceptible area of the oral cavity.
Risk factors and the incidence of overweight and obesity in pre-school children from the southern part of Poland
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Dereń, Katarzyna; Jarmakiewicz, Sara; Sokal, Aneta; Łuszczki, Edyta; Motyka, Elżbieta; Wyszyńska, Justyna; Kowal, Regina; Mazur, Artur
Introduction. In recent years there has been a significant increase in the prevalence of overweight and obesity in humans. It turns out that the problem is not limited to adults; excessive body weight is occurring in children more often. Aim. The main purpose of this work was to determine the prevalence of overweight and obesity in preschool children from the Rzeszów district, and to determine risk factors for occurrence. Materials and survey method. The study was conducted among 200 preschool children (3 - 6 years of age) from the Rzeszów poviat area. Measurements of height, weight, and determination of BMI were performed and these values are standardized according to the WHO centile grids appropriate for each age group. Survey results. Normal weight was observed in 58% of the respondents, 11% were overweight, and 10.5% were obese, whereas 20.5% of children had undernourishment. Obese children were the largest group among 6-year-olds. Among 4 year old children, abnormal body weight were more frequent in boys. On the other hand, in children aged 5 years, undernourishment or overweight was found more frequently in girls. Conclusions. The study did not confirm a significant relationship between gender, place of residence and socio-economic situation of respondents, and the prevalence of overweight or obesity. The results of this study indicate that the problem of excessive body weight refers to the increasing number of children.
The comorbidity of papillary thyroid carcinoma and the primary hyperparathyroidism
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Podlasek, Robert; Bednarczyk, Grzegorz; Świder, Grzegorz
Introduction. The prevalence of papillary thyroid carcinoma (PTC) in patients with primary hyperparathyroidism (PHPT) is low, it can be estimated around 2 to 4%. For unknown reasons it is higher than the prevalence of PTC in the overall population. The authors analyse the comorbidity of PTC with PHPT on patients treated in their institution. Material and method. The analysis covered medical records of 885 patients subject to the thyroid resection procedure and 95 patients operated for PHPT, the procedures were performed in years 2005-2014. Results. In the above-mentioned period there were 121 patients operated due to a malignant thyroid tumour and there were 95 patients that had surgery for PHPT. There were 4 cases of comorbidity of PHPT with papillary thyroid cancer. Prevalence of PTC at the patients with PHPT was 4.2%. In two out of the four cases, both diseases were diagnosed prior to the procedure and the single appropriate surgery i.e. total thyroidectomy and excision of parathyroid adenoma was performed. In the other two cases false positive localisation of parathyroid adenoma occurred due to metastatic cancerous lesions in cervical lymph nodes. The diagnosis of PTC was made postoperatively based on surgical specimen examination. Second surgical procedure appropriate for this diagnosis was necessary in both cases. Conclusions. The comorbidity of PHPT and PTC is clinically important and should be taken into account in the case of patients with PHPT and thyroid tumours. There is the possibility of false positive localization of parathyroid adenoma in the case of metastatic cancerous lesions in cervical lymph nodes.
Analysis of the correlation between body composition, construction and aerobic capacity in teenage team sport training
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Matłosz, Piotr; Michałowska, Jadwiga; Sarnik, Grzegorz; Herbert, Jarosław; Przednowek, Krzysztof; Grzywacz, Renata; Polak, Ewa
Introduction. Research results indicate that a low level of physical fitness is associated with a high percentage of fat in the body and low levels of physical activity. The aim of this work was to assess the relationships between selected morphological indicators, and the level of aerobic capacity in adolescents attending the schools with team sports. Material and methods. The studies covered students participating in sports in middle school and high school; the study group included 90 boys aged 13-19 years. Body height and weight were measured as well as waist and hip circumference. Body weight components were assessed by using a Tanita Body Composition Analyzer. A Fitnessgram® test battery was used to assess physical fitness. Results. Research results indicates systematic increase of somatic characteristics such as weight, body height and waist and hips circuits with age. Taking into account the results obtained with the PACER test indicate a very good aerobic capacity of tested boys. Conclusions. Age is a factor that improves motor fitness of physically active adolescents. There is no linear relationship between BMI and fitness among the boys who regularly train team sports, but both lower and higher BMI values seem to be connected with lower physical fitness.
Effects of obesity on health condition with an emphasis on bone tissues disorders
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Wolski, Dariusz; Michalik, Joanna; Bieńko, Marek; Radzki, Radosław P.
Introduction. Obesity is today one of the most dangerous and the fastest growing civilization diseases in the world. The number of overweight or obese people is continually increasing. Obesity is defined as abnormal fat accumulation in an organism that may cause health impairment. Obesity may be conducive to an increased risk increase for occurrence of cardiovascular diseases as well as stroke, some types of cancer, endocrinal disorders, osteoarthritis and other bone disorders. Some studies have demonstrated that high body mass index (BMI) is protective against the development of osteoporosis and osteoporotic fractures in men and women. In slim people with a lower BMI than normal, weight loss is associated with low bone mineral density (BMD). On the other hand, obesity in childhood may lead to fragility fractures and may lead to early development of osteoporosis in adulthood. Currently, we have numerous methods for measurement of obesity such as dual-energy X-ray absorptiometry (DXA), bioelectrical impedance analysis (BIA), total body electrical conductivity (TOBEC) as well as magnetic resonance imaging (MRI) and computed tomography (CT). These methods are useful for diagnosing obesity and bone tissue disorders such as osteopenia with sarcopenia or osteoporosis, in particular in perimenopausal women and men after andropause. Aim of the study. The purpose of the study was review the literature on obesity and bone tissue disorders and their interrelations. Material and method. Analysis of literature.
Singlet oxygen lifetime and diffusion measurements
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Ożóg, Łukasz; Aebisher, David
Introduction. Photodynamic therapy (PDT) is considered to be a promising antitumor methodology due the cytotoxicity of singlet oxygen (1O2). Aim. To present singlet oxygen which is highly reactive and decomposes to the ground state rapidly. Material and methods. Analysis of literature. Results. This review presents techniques to measure lifetime and diffusion of 1O2.
Biological properties of Cistus species
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Stępień, Agnieszka; Aebisher, David; Bartusik-Aebisher, Dorota
Aim. This paper presents a review of scientific studies analyzing the biological properties of different species of Cistus sp. Materials and methods. Forty papers that discuss the current research of Cistus sp. as phytotherapeutic agent were used for this discussion. Literature analysis. The results of scientific research indicate that extracts from various species of Cistus sp. exhibit antioxidant, antibacterial, antifungal, anti-inflammatory, antiviral, cytotoxic and anticancer properties. These properties give rise to the possibility of using Cistus sp. as a therapeutic agent supporting many therapies.
Medicinal benefits from the use of Black pepper, Curcuma and Ginger
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Bober, Zuzanna; Stępień, Agnieszka; Aebisher, David; Ożóg, Łukasz; Bartusik-Aebisher, Dorota
Introduction. Black pepper, Curcuma and Ginger are three of the most popular and most frequently used spices. Due to their beneficial medical and pharmacological properties, they are increasingly appreciated phytotheraputic plants. Most of their actions are attributed to their biochemical compositions. Aim. Our intention is to equip the reader with the information and knowledge necessary to understand the role of natural products in the drug discovery process and to enable the assessment of potential benefits and harms of plant-based medicines when advising patients who wish to use them. Material and methods. Analysis of literature. Results. In this paper, we reviewed the use of Black pepper, Curcuma and Ginger documented in the treatment of colds and flu, support for immunity, but also use in digestive ailments and beneficial effects on the cardiovascular system and immune system.
Military candidate health qualification and adjudication
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Żal, Marcin; Więch, Paweł; Bartusik-Aebisher, Dorota; Hejda, Grażyna; Binkowska-Bury, Monika
Introduction. This study reviews the link between personal health and military qualifications. It was found that there is evidence of a strong link between obesity levels across young individuals and military qualification adjudication. Aim. The purpose of the study was to review the literature about significance of the rules for adjudicating on the ability to perform active military service and analysis of the literature regarding the health condition of Polish citizens subject to perform obligatory military service. Materials and method. Analysis of foreign and Polish literature.
Comparison of two suicide attempts with long-acting insulin – The rare way to commit suicide
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Radzka, Agnieszka; Ciechański, Krystian; Tkaczyk, Jędrzej; Brożyna, Klaudia; Tchórz, Michał
Introduction. In previous years, the number of suicide attempts has increased in Europe. Intoxication with hypoglycemic drugs, including insulin is a rare a tool for attempting suicide that may lead to a severe patient status. Aim. The aim of the study was to assess the severity of insulin poisoning with examples of two patients. Methods. The analysis of clinical history of patients and review of available literature. Results. A 22-year-old patient was hospitalized in the Department of Toxicology and Cardiology due to a suicide attempt in the way of insulin poisoning; time of poisoning was unknown, and the level of glucose was indeterminable. The patient was treated with intensive specific pharmacotherapy. After hospitalization, which lasted 5 months, the patient’s condition had been stabilized but with no verbal contact and quadriplegic paralysis. Another patient was a 41-year-old woman hospitalized two times in the Department of Toxicology and Cardiology due to the insulin poisonings. In each case of hospitalization of this woman, severe recurrent hypoglycemia was observed up to 25 mg% until the fifth day of hospitalization and the treatment used improved the patient’s condition and there was no development of serious complications. Conclusion. Normally effective treatment at the right time can recover the patient completely.
Combined aplasia of frontal and shenoid sinuses with hypoplasia of the maxillary sinus
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Błochowiak, Katarzyna; Kamiński, Bartłomiej
Introduction. Combined aplasia of multiple sinuses is extremely rare. Agenesis of the paranasal sinuses is an uncommon clinical condition that appears mainly in the frontal (12%) and maxillary (5-6%) sinuses. Case report. In this paper, we present the case of a 74-year-old woman with combined frontal and shenoid sinus aplasia accompanied by unilateral maxillary sinus hypoplasia. The findings were confirmed by a computed tomography scan of paranasal sinuses. The reason for admission was persistent headache, numbness of the left cheek and left alveolar process, and occasional nasal blockage. Discussion. The uniqueness of our case is that the patient is an elderly female with combined aplasia of the frontal and sphenoid sinus with hypoplastic maxillary sinuses, whereas previously reported cases were found in children and in young adults. Summary and conclusions. These anomalies can be misdiagnosed as chronic sinusitis or neoplasm. All potential sinus anomalies will have clinical implications and will hinder conventional and functional endoscopic sinus surgery.
Investigation of focal necrotizing pneumonia after diesel fuel ingestion
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Ciechański, Krystian; Radzka, Agnieszka; Brożyna, Klaudia; Tkaczyk, Jędrzej; Kędziora, Aleksandra; Tchórz, Michał
Introduction. Diesel oil is a mixture of hydrocarbons. These compounds are widely used in everyday life. Oral exposures are most often accidental and affect mainly children, but they also happen in adults. Oral ingestion may lead to aspiration of pulmonary alveoli which may cause necrotizing pneumonia. Aim. The aim of the study is to assess te severity of diesel oil intoxication on an example of a presented case. Methods. The analysis of the clinical patient history and review of available literature. Results. A 27 year old patient was admitted to the toxicology department due to accidental diesel poisoning. Patient drank a small amount diesel oil, then suffered nausea and vomiting, which resulted in aspiration of diesel to respiratory system. During hospitalization focal necrotizing pneumonia was diagnosed. Patient was treated with intensive specific pharmacotherapy. On the 11th day of stay, the patient was discharged with recommendation of control in the pulmonological and toxicological clinic and chest x-ray examination in order to diagnose the suspicious oval change discovered in the right lobe during hospitalization. Conclusion. First toxicity symptoms are non-specific, so well collected anamnesis is crucial. Complications of hydrocarbon ingestion can be a threat to patient’s life. Due to rarity of the problem, there are no clearly defined treatment guidelines.
Hyponatremia secondary to the syndrome of inappropriate secretion of antidiuretic hormone (SIADH) during the course of lung cancer. A case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2018) Radzka, Agnieszka; Fałkowska, Urszula; Sławiński, Aleksander; Ryczkowski, Aleksander; Obel, Ewa; Lewicki, Marcin
Introduction. Hyponatremia is a frequently observed electrolyte disorder among patients with cancer. In 1957, Schwartz et al. reported the first case of a patient with hyponatremia due to SIADH, secondary to lung cancer. From that moment on, there has been data published that indicates patients with SIADH are less responsive to chemotherapy, have greater predisposition to central nervous system metastases and are often characterized by an advanced stage of cancer during time of diagnosis. Hyponatremia has many possible causes, and the differential diagnosis can pose a challenge. Aim. The aim of the study was to consider the occurrence of secondary hyponatremia in the course of cancer and the significance of this disorder in the prognosis of the disease. Methods. An analysis of the clinical history of the patient and a review of available literature. Results. A 66-year old patient with hyponatremia was admitted to the Department of Endocrinology, and lung cancer was determined as the cause of the aforementioned electrolyte disorder. Conclusion. SIADH secondary to cancers should be included in a differential diagnosis of every case of hyponatremia of undetermined etiology.

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