European Journal of Clinical and Experimental Medicine T.18, z. 3 (2020)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/5805

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The impact of ademetionine and ipidacrine/phenibut on the NCAM distribution and behavior in the rat model of drug-induced liver injury
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Muraviova, Diana; Kharchenko, Yuliia; Pierzynowska, Kateryna; Pierzynowski, Stefan Grzegorz ; Wolinski, Jarek; Dyomshyna, Olga; Zhyliuk, Volodymyr; Ushakova, Galyna
Introduction. Recently, more attention is being paid to the drug-induced liver injury (DILI) as a consequence of the tuberculos is treatment and the need for new medicine is emphasized. The use of isoniazid and rifampicin has a potentiating effect, which increases the risk of substancial liver damage. In turn, systemic accumulation of toxic metabolites leads to negative changes in various organs, including the brain. It causes an imbalance in biochemical and neurophysiological processes in the brain, ultimately giving the onset to the development of hepatic encephalopathy. Aim. The effects of rifampicin and isoniazid on the central nervous system have not been studied before and we aimed to evaluate the impact these two substances have on the neuronal cell adhesion molecules (NCAM) distribution and animal behavior in the rat model of DILI. Material and methods. The 24 male Wistar rats, weighing 180-220 g were used for the experiment and divided to the groups (n=6): 1 – control; 2 – rats with experimental DILI; 3 – rats with DILI plus the intravenous infusion of S-adenosyl-L-methionine at a dose of 35 mg/kg; 4 – rats with DILI plus a fixed combination of ipidacrine hydrochloride at a dose 1 mg/kg body weight and phenibut at a dose 60 mg/kg body weight daily for the last 14 days of the experiment. All experimental procedures were carried out in the accordance with the principles outlined in the current Guide to the Care and Use of Experimental Animals. The locomotor and research activities were studied in the open field test. The activity of aspartate aminotransferase (AST, ЕС 2.6.1.1) and alanine aminotransferase (ALT, ЕС 2.6.1.2) in the serum of rats were tested to confirm the liver damage. The quantitative analyses of soluble and membrane forms of NCAM were performed with ELISA. The ANOVA followed by a Tukey post-hoc test was used to assess statistical differences between groups. Results. Our investigation in the open field test revealed a significant decrease in the locomotor and research activity of rats after 28 days of rifampicin and isoniazid administration. The recovery of investigated parameters was observed in groups of animals treated with ademetionine (AD group) or combination of ipidacrine and phenibut (IP/PB group). We also observed that changes in rats’ behavior were consistent with alterations of the NCAM levels in the thalamus and hippocampus. Thus, the level of membrane NCAM was significantly decreased under DILI in both investigated brain regions (thalamus and hippocampus), while both AD and IP/PB treatments restored membrane NCAM levels towards those observed in the control group at least in the hippocampus. Conclusion. Obtained data suggests that both ademetionine and combinated drug containing ipidacrine and phenibut possesses neuroprotective properties and could prevent the decline in synaptic plasticity under antitubercular therapy.
The Impact of ‘Stay At Home’ Orders on Emergency Room Admissions
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Kocak, Abdullah Osman; Dogruyol, Sinem; Akbas, Ilker; Kerget, Bugra; Akgol Gur, Sultan Tuna; Cakir, Zeynep
Introduction. The 2019-novel-coronavirus (2019-nCoV) outbreak has become a common problem for the whole world. Aim. To investigate the impact of the 2019-nCoV pandemic period in our country on emergency room admissions. Materials and methods. The study was designed as a retrospective cohort. The first case of pneumonia infected with nCoV in our country was diagnosed on March 11, 2020. Considering the date of March 11, 2020, emergency room admissions for two periods of 7 days were investigated, pre-COVID-19 and COVID19. Demographic data, admission diagnosis, vital findings, stay times in emergency room, terminations and emergency department mortality examined. A group of ‘geriatric’ patient populations were created to examine the admission characteristics of patients aged-65 and over. Results. The 3466 patients included in the study. The average number of daily admissions was significantly higher in the pre-COVID-19 period (350.4 ± 54.5), compared to the COVID-19 period (144.7 ± 20.2, p=0001). While the proportion of cardiac- caused admissions increased during the COVID period, the proportion of gastrointestinal-induced admissions decreased (p<0001). Hospitalization rates for both adult and geriatric patients increased during the COVID period (p<0001). Conclusion. Despite all the negativity caused by the outbreak, this period has been one in which the public is aware of unnecessary emergency room which has been subsequently lessened.
Seroprevalence of Toxoplasmosis among Human Immunodeficiency Virus infected pregnant women in Abuja Teaching Hospital, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Zakari, Maryam Muhammad; Isah, Aliyu Yabagi; Offiong, Richards; Yunusa, Thairu; Abdullahi, Idris Nasir
Introduction. Toxoplasmosis is a neglected parasitic infection that has economic and epidemiological significance. Data on toxoplasmosis seroprevalence among Human Immunodeficiency Virus (HIV) infected pregnant women may be of obstetric and neonatal concern. Aim. The study was designed to determine the seroprevalence of Toxoplasmosis and associated risk factors in HIV-positive pregnant women attending the University of Abuja Teaching Hospital, Abuja, Northcentral Nigeria. Material and methods. This was a hospital-based cross-sectional study. A total of 160 HIV seropositive pregnant women were recruited. Blood samples were collected and tested for anti-T. gondii IgM and IgG using Enzyme Linked Immunosorbent Assay (ELISA). Structured questionnaires were used to collate the sociodemographic variables of participants. Results. Out of the 160 of HIV seropositive pregnant women, the seroprevalence anti-T. gondii IgG and IgM were 29.4% and 4.4%, respectively. There was no significant association between anti-T. gondii and all sociodemographic variables studied (p>0.05). Conclusion. The overall result of this study revealed that the majority of pregnant women were exposed to toxoplasmosis much earlier in life. Hence, these findings will assist obstetricians and gynecologists in the early diagnosis and management of Toxoplasma gondii infection in pregnant women, especially HIV coinfected ones with IgM seropositivity.
Knowledge, perception and child care practices among adolescent mothers in Ibadan Metropolis, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Oyewole, Oyediran Emmanuel; Todowede, Christiana Mautin; Dipeolu, Isaac Oluwafemi
Introduction. There is little information regarding childcare practices among adolescent mothers in the study areas. Aim. This study was aimed at investigating knowledge, perception and childcare practices among adolescent mothers. Material and methods. A descriptive cross-sectional survey was conducted on randomly select 382 adolescent mothers. A validated semi-structured questionnaire was used to collect data, which were analysed using, descriptive and multivariate analyses with p-value set at 0.05. Age of respondents was 18.5±0.7 years. Results. Majority (80.6%) had poor knowledge of when to start ante-natal care. Also, 70.0% of the respondents could not perceive growth monitoring as a necessary strategy for child survival and 86.4% perceived diarrhoea as normal for children during the teething period. Many (58.4%) did not practise exclusive breastfeeding. Respondents with secondary education were less likely to have poor knowledge than those with primary education (OR: 0.2, CI: 0.6-0.9, 95%). Respondents, who received supervision from older women during childcare, were less likely to have poor childcare practice than those who did not (OR: 0.2, CI: 0.4-0.7, 95%). Conclusion. Respondents had poor knowledge of childcare practices when childcare survival strategies were used as the yardstick for evaluation. Involvement of older women is suggested to assist adolescent mothers improve their knowledge and practices of childcare.
The larynx cancer in vitro study by MRI relaxtion time of water
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Domka, Wojciech; Ożóg, Łukasz; Bartusik-Aebisher, Dorota; Aebisher, David
Introduction. Squamous cell carcinoma (SCC) of the larynx accounts for a significant percentage of all head and neck cancers. Aim. In this paper we determine the differences in magnetic resonance relaxation time (MRI) of water in cancerous and healthy larynx tissues. Material and methods. This study is aimed on T2 MRI modalities for monitoring morphology of larynx tissue. Results. Our results showed that T2 MRI relaxation time measured in larynx tissue can be used to assess early cancer condition of larynx tissues. The changes of T2 MRI correspond to tumor growth within normal tissue. Conclusion. The study showed potential of MRI for the non-invasive monitoring of larynx condition.
Cognitive behavioural therapy and core stabilization exercise on pain-related disability and psychological status in patients with non-specific chronic low back pain
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Akodu, Ashiyat Kehinde; Ogunbiyi, Thompson Adewale; Fapojuwo, Oluwaseun Akinleye
Introduction. Exercises have been shown to relieve symptoms in non-specific chronic low back pain (NSCLBP) patients. Aim. This study compared the effects of cognitive behavioural therapy (CBT) and core stabilization exercises (CSE) on pain-related disability, psychological status and sleep disturbance in patients with NSCLBP. Material and methods. This randomized controlled trial involved a total of thirty-seven (37) participants. They were randomly allotted into three groups [CBT (11), CSE (14) and control (12)]. The intervention was done once per week for duration of 60 minutes for the CBT group, 30 minutes for CSE group and 10 minutes for the control group twice per week for 8 consecutive weeks. Assessment of outcome was done at baseline, 4 weeks and 8 weeks. Data were analyzed using statistical package for social science version 25 at alpha level of less than 0.05. Results. The results of this study showed that there was significant improvement in the level of pain-related disability (p= 0.001), level of anxiety (p =0.001), depression (p = 0.01, p = 0.001, p =0.001) and sleep disturbance (p = 0.001) in all the groups (CBT, CSE, control) post treatment. Conclusion. CBT and CSE are both effective in the treatment of pain-related disability, sleep disturbance, and psychological status of NSCLBP patients.
Knowledge of modifiable risk factors for cardiovascular diseases among university undergraduates in Ibadan, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Oyewole, Oyediran Emmanuel; Solabi, Ayodele
Introduction. Undergraduates in many institutions live a lifestyle that could predispose them to non-communicable diseases (NCDs) including cardiovascular-related. Previous studies on modifiable risk factors (MRFs) against NCDs had focused mainly on adults, whereas young people should be prime targets for prevention programmes. Aim. This study was aimed at investigating knowledge of MRFs against cardiovascular diseases (CVDs) among university undergraduates in Ibadan, Nigeria. Material and methods. A descriptive cross-sectional design was adopted, where 500 undergraduates participated. Data were collected using Focus Group Discussion (FGD) guide and validated questionnaire. Data analyses were conducted using thematic approach and bivariate methods at 5% levels of significance, respectively. Results. Mean age was 22.8 }3.0 years and 51.4% were females. The majority reported that their fathers (82.8%) and mothers (83.0%) had no hypertension history. The FGD revealed that students were knowledgeable of MRFs and preventive behaviours but still engaged in unhealthy lifestyle practices. The MRFs identified included excessive alcohol consumption (85.4%), unhealthy diet (77.6%), physical inactivity (75.2%) and smoking (70.2%). Respondents (56.4%) had good knowledge of MRFs against CVDs; 57.0% had fair lifestyle practices and 54.8% had good knowledge of preventive behaviour against CVDs. Conclusion. Gender was significantly associated with knowledge of CVDs preventive behaviours. Institutional-based lifestyle modification programmes, using peer group education is suggested.
Behaviors, attitudes and opinions of medical students in the field of smoking and anti-smoking counseling in two countries of Central and Eastern Europe
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Hejda, Paulina; Hubert-Lutecka, Agnieszka; Chmiel, Zdzisława; Sidor, Adam; Iwanowicz-Palus, Grażyna; Żal, Marcin; Koryl, Agnieszka; Binkowska-Bury, Monika
Introduction. Europe is the region with the greatest proportion of deaths (16%) attributable to tobacco smoking worldwide. Medical students and physicians should set an example of tobacco-smoking abstinence for their patients. Aim. The aim of the study was to compare opinions on behaviors and attitudes of Czech and Polish medical students about tobacco smoking and the position of a physician in anti-smoking counseling. Material and methods. The Global Health Professions Student Survey (GHPSS) was conducted among 707 medical students in Czech Republic in 2011 and among 1164 medical students in Poland. Results. Twety percent of polish and 25,7% of Czech medical students declared current tobacco smoking. Eighty-one percent in Poland and 60% in Czech Republic felt that physicians should be trained in smoking cessation techniques but only 27% of the medical students in Poland and 2,8% in Czech Republic , declared that such a course had been realized during the course of their education. Conclusion. Over a fifth of Polish students and a quarter of Czech students declared themselves as active smokers. It is worrying that about half of Polish students were exposed to environmental tobacco smoke, while only one-fifth of Czech students declared such exposure. Polish and Czech students agreed that the doctor will play an important role in the patient’s smoking cessation process and that physicians should give advice on quitting smoking.
Cytotoxic and anticancer activity of Moringa oleifera
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Szlachetka, Kinga; Kut, Paulina; Stępień, Agnieszka
Introduction. Given its very strong antioxidant properties, Moringa oleifera is particularly noteworthy among medicinal plants. The high contents antioxidants in the M. oleifera determining her antioxidant activities deciding for very important anticancer properties. Aim. The aim of the paper is to provide an overview of the cytotoxic and anticancer activity of Moringa oleifera. Material and methods. This review was performed based systematic analysis of literature. Analysis of the literature. The results of scientific research conducted in vitro indicate that extracts from Moringa oleifera significantly affect the development of human cancer cells such as myeloma, leukemia, cervix, breast, colon, lung, liver, neuroblastoma, pancreas, colorectal, epidermoid, oral, ovarian, muscular, prostate, skin. Conclusion. This indicates Moringa oleifera as that they may be used as a therapeutic agent to support oncological therapies.
Forms of physical activity of the elderly
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Czarnecki, Piotr; Podgórska-Bednarz, Justyna; Perenc, Lidia
Introduction. Physical activity is known to be an important factor influencing health throughout human life. This issue has become crucial for public health due to the aging of the population in both developed and developing countries. Aim. is to present a literature review on the forms of physical activity undertaken by the elderly, as well as on issues related to physical activity and the population aging. Material and methods. The study was prepared on the basis of a review of Polish and foreign literature. The following databases and data sources were used: EBSCO, ScienceDirect and Google Scholar. An additional source of data were the websites of the Central Statistical Office. Strictly defined key phrases were used during the collection of literature. The work has been divided into thematic subsections on the aging of the society, the impact of physical activity on health and the main topic, i.e. forms of physical activity selected by the elderly. Analysis of the literature. The number of elderly people in Polish society has increased by almost 3.7 million over three decades. Therefore, an important topic is prophylaxis aimed at increasing the number of days in good health, largely covering the broadly understood activation of the elderly. The available data indicate that only 12% of elderly people undertake physical activity once a week. The most common form of spending free time actively is walking (as many as 73% of people in this population declare this form of physical activity in one of the presented studies). Conclusion. Organized forms of physical activity are undertaken much less frequently by the analyzed age group mainly due to financial limitations and limited availability of sports infrastructure.
Pancreatic tumor metastasis to the navel in a case with three primary tumors – case report and review of the literature
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Dilek, Fatma Hüsniye; Tosun, Furkan; Atay, Arif; Dilek, Osman Nuri
Introduction. Sister Mary Joseph nodule (SMJN) is a metastasis that can occur in the umbilical region due to many tumors in the abdomen. Most of the cases are of gastrointestinal system origin and are often an indicator of poor prognosis. It can be seen in 1-3% of intraabdominal and pelvic malignancies. In the literature, around 300 studies are presented, mostly in the form of case reports. Very few (7-9%) of the cases with SMJN are from pancreatic origin. In our literature review, we found that in the majority (>90%) of SMJN cases due to pancreatic tumors, the lesions originated from the pancreatic tail and/or body, and tumor marker Ca-19.9 was very high in most cases (>90%). Aim. Here, the case of SMJN seen in a patient with three different primary tumors was discussed in the light of the literature data. Description of the case. Here, our case, whose third primary malignancy was detected in the pancreas in the PET/CT examination performed to investigate the origin of SMJN in a 68-year-old female patient who had undergone surgery due to breast in 2011 and endometrium cancers in 2018 and came with umbilical metastasis, is presented in the light of the literature data. Conclusion. As a result, in our case, which was followed up due to two primary tumors, it became important to know the origin of the SMJN that occurred due to the third primary tumor detected during the CT and PET/CT examination due to the newly emerging SMJN. It is important to know the origin and histopathological features of the SMJN in order to determine the treatment to the patient.
Vascular surgery and an occurrence of stroke
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Leksa, Natalia; Uryniak, Adam; Aebisher, David; Leksa, Dawid; Bartusik-Aebisher, Dorota
Introduction. The brain responds to metabolic disorders with a limited array of symptoms and signs. The brain has enormous needs in terms of substrate and blood flow. Aim. This paper presents a case report reporting episode of stroke. Description of the case. The incidence of cerebral vascular episodes in the form of strokes, transient episodes of cerebral ischemia is reported. Conclusion. The chemical constituency of the brain are generally quite different from those of other tissues. Stroke is a clinical syndrome characterized by sudden focal or generalized brain dysfunction.
Bladder leiomyoma: diagnostics, laparoscopy, and treatment
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Godlewski, Dominik; Pszczółkowski, Patryk; Fedus, Tadeusz; Aebisher, David
Introduction. Leiomyosarcoma is the most common benign tumor of the bladder. However, it is only a small percentage of all proliferative changes of this organ. Aim. Presentation based on two clinical cases of diagnostics and surgical treatment from laparoscopic access of bladder leiomyoma. Description of the cases. Case 1. The work contains a diagnosis based on transvaginal ultrasound (TVUS), cystoscopy and computed tomography (CT), as well as partial laparoscopic bladder re section of leiomyoma in young women. Case 2. The case of young women with the histopathological result confirmed bladder leiomyoma. Conclusions. Leiomyoma is a rare bladder cancer. Laparoscopic bladder resection is a safe method that leads to healing.
An iliac artery aneurysm
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Leksa, Natalia; Leksa, Dawid; Gałuszka, Łukasz; Uryniak, Adam; Aebisher, David; Galiniak, Sabina; Bartusik-Aebisher, Dorota
Introduction. Isolated common iliac artery aneurysms (CIAs) are rare. The rarer are rupture of the common iliac artery. We can treat them surgically: classic or endovascular. Open surgery has a main role in the management of aneurysms not suitable for repair by endovascular techniques. Aim. The aim of the study is to present the possibility of occurrence of such a disease at a young age, to indicate non-characteristic symptoms that may predict the above-mentioned disease entity at the level of a primary care physician or SOR. Review of medical publications from 2000-2019 regarding guidelines or methods of conduct in that cases. Description of the case. A patient 39 years old, admitted to the Department of Vascular Surgery, in an interview: about 15 years ago severely beaten, as a result of injuries total loss of hearing, memory and basic skills such as: speech, writing, reading, hospitalized over 6 months. Conclusion. Good rehabilitation and patient persistence restored cognitive skills. Advances in surgical has lowered the mortality and morbidity rates even in patients.
Stroke masks – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Chmielewska, Beata; Leksa, Natalia; Aebisher, David; Galiniak, Sabina; Leksa, Dawid; Bartosz, Seweryn; Bartusik-Aebisher, Dorota
Introduction. Stroke is a common vascular disease encountered in the work of a practitioner. Despite this, his differentiation is difficult. This is due to a variety of diseases that can be a “mask” for stroke. These are neurological diseases other than vascular (brain tumors, epilepsy), head injuries and a number of metabolic disorders (fluctuations in glucose, electrolytes). Aim. This work aims to approximate the differentiation of this common disease entity. Case reports show both clinical view and diagnostic difficulties. Description of the cases. Case 1. The patient 59 years old treated for bipolar disorder, hypertension and alcohol abuse. Case 2. The patient 68 years old treated for type 2 diabetes, hypertension, ischemic heart disease, cholecystolithiasis – cholecystectomy. Conclusion. Stroke is a significant clinical and social problem both in Poland and in the world. Despite this, its diagnostics and especially differentiation is difficult. When analyzing the case of each patient with suspected sudden CNS vascular disease, all of them should be remembered. It should also be borne in mind that differential diagnosis cannot delay specific treatment for stroke.
Plasma Therapy: Why not for post – exposure prophylaxis in Health Care Professionals?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Nagoba, Basavraj; Gavkare, Ajay; Jamadar, Nawab
A concurrent outbreak of COVID-19 and methanol poisoning in Iran: Is this the time to make amendments to alcohol drinking laws?
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2020) Banagozar Mohammadi, Ali; Vahabzadeh, Maryam

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Przeglądanie European Journal of Clinical and Experimental Medicine T.18, z. 3 (2020) według Data dodania