European Journal of Clinical and Experimental Medicine T.17, z. 3 (2019)

URI dla tej Kolekcjihttp://repozytorium.ur.edu.pl/handle/item/5054

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Stem cell therapy for renal failure: present considerations
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Wiwanitkit, Viroj
Dynamics of changes in the level of IgA in patients with bronchial asthma against the background of excessive body weight or obesity
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Lahoda, Daria; Velychko, Valentyna
Introduction. Among patients with asthma, a lot of attention is being given to, at the present time, to such comorbidity as excessive body mass (EBM) or obesity. Aim. To evaluate the level of IgA in patients with bronchial asthma against the background of excessive body weight or obesity and to evaluate the effects of drug on the bacterial lysate and inosine pranobex. Material and methods. According to the design, the study was conducted in two stages: the first stage – examination of 105 patients with asthma. 105 patients with a basic diagnosis of asthma were examined whose average age was 41.19 ± 1.05 years, 75 patients were found to have EBM or obesity (BMI 31.67 ± 0.53) who were included in the main group and 30 patients with NBMI (BMI 22.13 ± 0.32), which were the comparison group. Results. The patients in the main group with a severe course had significantly lower serum IgA values than the patients in the comparison group (p<0.05), but the statistically significant difference between this index in the patients with a severe course in the main group and the control group was not revealed. The patients in the main group had a significant increase in the level of secret IgA against the background of the use of treatment-and-prophylactic complex (TPC) with the inclusion of a preparation of bacterial lysate in combination with inosine pranobex against the background of training in asthma school, receiving the basic treatment (p<0.05). Conclusion. Patients with asthma who have large BMI have a more severe course of bronchial asthma. A Correlation relationship was established in the group of patients with bronchial asthma and with excessive body weight or obesity between the level of sIgA and the severity of the asthma course; there is a direct strong correlation. Patients in the main group had a significant increase in the level of sIgA against the background of the use of TPC with the addition of a basic treatment by the preparation of bacterial lysate together with inosine pranobex.
Association of fat patterning, type 2 diabetes mellitus and MTHFR gene polymorphism: a study among the two ethnic groups of Tripura, North-East India
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Bhattacharya, Priyama; Chatterjee, Diptendu; Sarkar, Pranabesh; Ghosh, Kusum; Bandyopadhyay, Arup Ratan
Introduction. Type 2 Diabetes Mellitus (T2DM) is a group of metabolic disorders resulting from insufficient action of insulin. The etiology of T2DM is multi-factorial that includes genetic factors, obesity and lifestyles. Recent reviews of overall and stratified meta-analyses demonstrated the association between MTHFR polymorphism (C677T) including fat distribution and risk of T2DM. Publications of Indian context regarding fat patterning and MTFHR genetic polymorphism of the North East Indian population are insufficient and scant among the ethnic population of Tripura. Aim. In this backdrop, the present study is the first attempt to understand the relationship of fat patterning, MTHFR gene polymorphism and T2DM among two Tibeto-Burman speaker endogamous ethnic populations (Chakmas-the migrant group and Tripuris – the aboriginal group) of Tripura, North East India. Material and methods. The present study consists of age matched 280 males (Chakmas 147 and the Tripuris 133) from Tripura. Anthropometric and metabolic (Fasting Blood Glucose) variables and to discern obesity, blood glucose level and genotyping of MTHFR was performed following standard techniques. Results. The result revealed significant (p<0.05) association of obesity, TT genotypes and fasting blood glucose among the Chakmas with in comparison to the Tripuris. Conclusion. In this first attempt from North East India on the aspects of association of fat Patterning, Type 2 Diabetes Mellitus and MTHFR gene polymorphism suggests that the Chakmas are more diabetic, and this might be due to the concomitant effects of T alleles and higher central obesity and Percent Body Fat (PBF). More population screening from other under-represented indigenous populations of North East India is needed for prevention of metabolic disorders.
Health behaviors in professionally active nurses – preliminary research
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Kilar, Renata; Harpula, Kinga; Nagórska, Małgorzata
Introduction. Health behaviors are all behaviors related to health. The study was aimed at recognizing the health behaviors of professionally active nurses. Aim. The aim of the study was to evaluate health behaviors presented by professionally active nurses. Material and methods. 103 nurses were included in the study. The method of diagnostic survey was used in the paper, and the research tool was the author’s questionnaire for socio-demographic data and the Inventory of Health Behaviors. Results. Nearly 60% of the respondents declared participation in preventive examinations. 70% of nurses put the family first in the hierarchy of life values. In the group of professionally active nurses, the value of health behavior index was 80.52 points. Conclusion. The greatest value in the life of nurses was the family right after health and work. Nurses declared regular participation in preventive screenings. They presented the average level of health behaviors. The nurses’ educational level positively affected the level of their health behavior. Nurses living in the countryside showed a higher level of health behavior. Nurses with chronic condition presented a lower level of health behaviors than their healthy colleagues.
The factors discriminating the results of screening test aimed at detection of scoliosis and detection of flexibility disorders in group of preterm children at the beginning of school age
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Piwoński, Paweł; Perenc, Lidia; Walicka-Cupryś, Katarzyna; Zajkiewicz, Katarzyna; Rachwał, Maciej; Drzał-Grabiec, Justyna; Przygoda, Łukasz; Cyran-Grzebyk, Barbara; Hudáková, Zuzana; Czarnecki, Piotr
Introduction. The threshold of compulsory schooling for prematurely born children is of particular importance. It’s a period of intense physical development which may increase the risk of scoliosis. Aim. The aim of this research is to determine whether age, gender, BMI value and selected elements of perinatal interview discriminate the results of screening test aimed at detection of scoliosis and flexibility disorders in group of preterm children at the beginning of school age. Material and methods. The study population consisted of 61 preterm children aged 5–8 years. The study included perinatal interview, BMI assessment, screening tests to detect scoliosis and flexibility. Results. Statistically significant dependence was obtained between age and normal and abnormal results of the screening test aimed at detection of scoliosis and between the result of the screening test for detecting flexibility disorders and: age, number of foetuses, assessment on the Apgar scale. Conclusion. The results of screening test aimed at occurrence of scoliosis in group of preterm children are significantly correlated with the age and screening test aimed at occurrence of the flexibility disorders are discriminated by age, origin from monoor multi-foetus pregnancy and assessment on the Apgar scale.
Evaluation of neutrophil phagocytic, complement functions, and cytokines expression among diabetic patients in Abuja, Nigeria
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Babandina, Musa Muhammad; Mainasara, Abdullahi Suleiman; Bakare, Mustapha; Emeribe, Anthony Uchenna; Shuwa, Halima Ali; Haruna, Shamsuddeen; Muhammad, Aminu Said; Abdullahi, Idris Nasir
Introduction. Inflammatory response in Diabetes Mellitus (DM) begins with chronic sub-clinical inflammations as a result of insulin resistance and activation of both innate and adaptive immune system as the disease progresses to complicated diabetes. Hence, the present study investigated the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among diabetic and non-diabetic patients attending the National Hospital in Abuja, Nigeria. Aim. To evaluate the neutrophil phagocytic, complement function (CH50), and some cytokine profiles among post-operative septic diabetic and post-operative septic non-diabetic patients at the National Hospital in Abuja, Nigeria. Material and methods. Subjects were recruited by convenient sampling technique through interviewer-administered questionnaires. Subsequently, blood samples were collected. Fasting blood sugar (FBS) (mmol/L) was determined using glucose oxidase method. Neutrophil function test (Fmol/phag) was assayed using nitroblue tetrazolium reduction test (NBT). Hemolytic complement function (CH 50) test was conducted using serum harvested from sheep sensitized with human group (ORh D +ve) red blood cells. While serum Interleukin-4, -6, -10 and TNF- α were determined using Enzyme Linked Immunosorbent Assay (ELISA). Results. Mean ±} Standard deviation (SD) of FBS concentration of 10.5 ±} 1.3 (mmol/|L) among diabetic and 4.7 ±} 0.9 (mmol/L) among non-diabetics was recorded. There is a decrease in neutrophil phagocytic function with a mean ±} SD of 5.4 ±} 2.1 (Fmol/ phag) in diabetics compared to 9.2 ±} 2.1 (Fmol/phag) in non-diabetics. Similarly, complement (CH 50) function and C-reactive protein were significantly lower in diabetics when compared to non-diabetics (p<0.001). There was a significant difference in IL-6 concentration between diabetics and non-diabetics groups, but no significant difference was observed in TNF-α, IL-4 and IL-10 concentrations between study groups (p>0.05). TNF-α and IL-6 was significantly higher in diabetics with cardiovascular disorders compared to non-diabetics subjects with cardiovascular disorders (p<0.001). Conclusion. Findings from this study revealed the association of complement, neutrophil phagocytic function, CRP and IL-6 among septic diabetic patients,. In addition TNF-α and IL-6 expression was higher in DM patients with cardiovascular disorders.
Factors determining the level of knowledge about parabens in cosmetics
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Marć, Małgorzata; Martyn, Julia
Introduction. Parabens are preservatives that can be found in all types of cosmetics. Aim. Analysis and evaluation of sociodemographic and psychosocial factors related to the level of knowledge of young people about parabens in cosmetics. Material and methods. Three hundred students from randomly selected colleges in the Subcarpathian Province took part in the study. The author’s questionnaire was used, which consisted of a statement, a scale of attitudes, and a test of knowledge as well as the Multidimensional scale of Health Locus of Control. Results. A high level of knowledge about preservatives in cosmetics was possessed by 14 % of respondents. The respondents who read cosmetic ingredients showed a higher level of knowledge about parabens more often than others. Young people were most often characterized by type MHLC strong-internal, accounting for 34% of the sample, and this group had a higher level of knowledge about parabens more often than the other respondents. Conclusion. The respondents who thought that their health depends only on them had a high level of knowledge about parabens. Respondents with a low level of knowledge about cosmetic ingredients are the type that increases the influence of coincidence and the type that magnifies the influence of others.
Epidemiology of breast cancer in Podkapackie voivodship
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Gustalik, Joanna; Bartusik-Aebisher, Dorota; Ostańska, Elżbieta; Przyczyna, Piotr; Osuchowski, Michał; Aebisher, David; Galiniak, Sabina; Kaznowska, Ewa
Introduction. Breast cancer is the second most prevalent reason for cancer deaths after lung cancer. Incidence rates have increased worldwide. Aim. To present epidemiology of breast cancer in Podkapackie voivodship. Material and methods. This analysis was performed using a systematic literature search. Results. In the Podkarpackie voivodship up until 2014, the incidence rate of female breast cancer was rising and in 2015 it dropped by 68 cases. Even though the survival rate is increasing, it is still one of the leading causes of cancer deaths placing second after lung cancer. Conclusion. Mortality rate, unfortunately, rose gradually. This shows that even though there is a National Health Program aiming at breast cancer awareness and prevention, it is still not enough to reduce the number of breast cancer deaths.
The use of imaging tests to obtain optimal margins in breast surgery
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Ostańska, Elżbieta; Bartusik-Aebisher, Dorota; Gustalik, Joanna; Aebisher, David; Galiniak, Sabina; Kaznowska, Ewa
Introduction. The proper negative margins (R0) breadth in the breast - conserving surgery for invasive breast cancer (IBC) and ductal carcinoma in situ (DCIS) is very important. The presence positive surgical margins (R1) is associated with the necessity of reoperation. It delays the adjuvant therapy and psychologically burdens the patient. The re-operation increases the costs of treatment. The introduction of mammography (MMG) increased detection of DCIS by 20%. With the increase in malignancy, cancer detection decreases in MMG, inversely in MRI groving. Effective preoperative and intraoperative diagnosis aims to reduce the number of R1 resections. Aim. The size of the tumor next to its biology, determines the clinical course of the tumor. The accurate analysis of imaging tests is important. Material and methods. This analysis was performed using a systematic literature search. Results. Adequate surgical margins in breast cancer surgery for breast cancer have been reviewed. It is important to know if the cancer is multifocal and what the extent of the tumor is. Conclusion. The adequacy of margins is important for adjusting the volume of excision. It is avoiding unnecessary resection of healthy breast tissue. It is essential for a good cosmetic result and the local recurrence rate. The combination of breast MRI with conventional breast imaging resulted in the lover rate of the R1 resectios and the lower rate of the re-operation.
Nootropics: Phytochemicals with Neuroprotective and Neurocognitive Enhancing Properties
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Crespo-Bujosa, Héctor B.; Suárez Rodríguez, Ramón L.F.
Introduction. Neurological chronic conditions represent a healthcare concern worldwide. They hinder a person’s functionality affecting family, social interactions, as well as academic and work performance. In addition, the complexity of these illnesses and the variable response to treatments, as well as the side-effects, call for the research and implementation of phytochemicals known as Nootropics to form part of an integrative treatment. Aim. To present the influence of nootropics on neuroprotection and neurocognition. Material and methods. Analysis of literature data found in the PubMed database. Results. Nootropics, which can be synthetic or natural, possess properties that translate in enhancement of mental or neurocognitive functions. Within the natural options, vitamins, plants and even fungi have been found to produce cognitive enhancement with less side-effects. Continuing research has shown promising therapeutic uses for B vitamins, Hericium herinaceus and Ginkgo biloba as coadjuvants in the treatment of neurologic chronic conditions to improve an individual’s neurocognitive functions and quality of life. Conclusion. Nootropics open the door for new research, clinical implementation and promotion of integrative health especially in cognitive neuroscience by implementing products of natural sources. This is particularly important in order to identify side-effects, drug-herb interactions, proper posology and synergic actions that may prove to improve neurocognitive functioning and health improvement.
Therapeutic possibilities of botulinum toxin in neurological disorders – treatment of limb spasticity in the course of brain damage
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Nowak, Przemysław; Balicka-Adamik, Luiza; Stybel, Katarzyna
Introduction. Botulinum toxin is produced by the anaerobic bacterium Clostridium botulinum. The sporulation form of the C. botulinum is widely found in the environment (in soil) and may develop in inappropriately stored food. The symptoms of poisoning occur 18-36 hours after consumption of contaminated food. Aim. The aim of this study is to present the benefits of using botulinum toxin in the treatment of spasticity of the upper and lower limbs in both adults and children. Material and methods. A literature review of the following databases was carried out: PubMed, UpToDate. Results. Botulinum toxin interferes with neural transmission by blocking the release of acetylcholine and causes muscle paralysis. The typical symptoms are diplopia, xerostomia, enteroparesis, speaking and swallowing disorders, as well as paralysis of respiratory muscles which leads to death. However, botulinum toxin is also a very potent medication. The biggest application is found in the field of neurology, inter alia, in the treatment of spasticity. Conclusion. The study provides current evidence regarding the safety and efficacy of botulinum toxin injection for spasticity of the upper and lower limbs. Botulinum toxin injections are applicable in the treatment of many neurological disorders and the list of indications will certainly become wider.
Multi Drug Resistant Tuberculosis
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Zacharia, Balaji; Roy, Antony
Introduction. Tuberculosis is one of the oldest infections known to mankind. Of all infectious diseases, tuberculosis causes the most fatalities of any infection. The incidence of tuberculosis on the rise due to the increased prevalence of HIV infection. The incidence of drug resistance strains of mycobacterium is also on the rise. When the mycobacterium is resistant to both INH and rifampicin it is called multi drug resistant tuberculosis. There is a primary and an acquired type of drug resistance. Multidrug resistant tuberculosis is a not only a problem for the patient but also for society at large. The treatment of multidrug resistant tuberculosis requires an entirely different approach. Aim. In this review, we are going to describe the etiopathogenesis, diagnosis, investigations and treatment of multi drug resistant tuberculosis. Material and methods. Analysis of the current literature. Results. Genetic factors, previous treatment, and other factors predisposes the onset of drug resistance. By early detection and prevention of spread of drug resistant strains we can prevent the spread of resistant strains. Conclusion. Drug resistance in tuberculosis is a very complex and dangerous problem. We have to prevent the development and spread of MDRTB. Good quality drugs should be used and made available to all sections of the population. Enhancing the National tuberculosis programs is the best way to attain an effective way to control this menace.
Open mesh repair of a voluminous recurrent inguinal hernia complicated by strangulation and intestinal obstruction
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Edeh, Anthony Jude; Nwangwu, Chukwuemeka Chijioke; Okenwa, Wilfred Okwudili; Anekpo, Chijioke Chinedu; Eze, Balantine Ugochukwu Nicholas; Basil-Nwachukwu, Chinonso Chibueze
Introduction. Inguinal hernia is a common surgical pathology in Nigeria but a giant (voluminous) recurrent strangulated inguino- scrotal hernia causing intestinal obstruction is very uncommon. Such a hernia, when it is recurrent and becomes complicated with strangulation and dynamic intestinal obstruction, presents many difficulties in management. Aim. To present the successful management of a case of a strangulated and obstructed giant recurrent inguinal hernia. Description of the case. Here we present the case of 47 year old man who had intestinal resection and anastomosis with prolene mesh repair of the posterior wall for a strangulated recurrent large inguinal hernia using the technique of tension free sutured prolene mesh popularized by Lichtenstein Conclusion. The patient recovered, was satisfied with his care and has been symptom free at 18 months of follow up. Giant recurrent hernias complicated by strangulated and intestinal obstruction are uncommon in Nigeria today, despite our resource- poor status. When they occur, tension free repair with sutured onlay prolene mesh after Lichtenstein, can be a useful and the best option with satisfactory results, as in the case reported.
Adrenomyeloneuropathy – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Leksa, Natalia; Aebisher, David; Galiniak, Sabina; Uberman-Kluz, Dominika; Bartosz, Seweryn; Bartusik-Aebisher, Dorota
Introduction. Adrenoleukodystrophy is a genetic disorder linked to the X chromosome, in which the peroxisomal beta-oxidation process is disturbed. It is a metabolic disease that results in the accumulation of very long chain fatty acids (VLCFAs - very long chain fatty acids) responsible for the symptoms of damage to the adrenal cortex, gonads and the brain. Aim. A clinical case is reported. Description of case. This article describes the case of a 64-year-old woman who had neurological symptoms for many years, gradually increasing without significant improvement after the treatment (periodic steroid therapy). Conclusion. Based on tests (including the determination of the ABCD1 gene and very long chain fatty acids - VLCFA), adrenoleukodystrophy was suspected.
Bladder Mullerianosis – a case report
(Wydawnictwo Uniwersytetu Rzeszowskiego, 2019) Ostańska, Elżbieta; Aebisher, David; Kaznowska, Ewa; Bartusik-Aebisher, Dorota
Introduction. Bladder mullerianosis is a rare and proliferative lesion that contains at least two types of ectopic Mullerian tissue in its wall. Aim. To present case of bladder mullerianosis. Description of case. The text contains a description of a clinical case of a 50-year-old woman admitted to a gynecological ward due to diarrheal symptoms and abdominal pain. In a CT examination of the abdominal cavity with contrast, within the posterior left-sided wall of the bladder a 43x25mm proliferative lesion suggestive of neoplastic character was revealed. Transurethral resection of the lesion (TURB) was performed. Histopathology revealed endosalpingiosis with small endocervical foci. The picture of hyperplasia met the criterion of mullerianosis. Conclusion. Bladder Mullerianosis is a very rare disease that occurs mainly in women of reproductive age. It has very good prognosis. It is important to differentiate the lesion with malignant tumor. The basis for the diagnosis is the histopathological examination of the lesion tissues taken during the surgery.

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Przeglądanie European Journal of Clinical and Experimental Medicine T.17, z. 3 (2019) według Data dodania