European Journal of Clinical and Experimental Medicine T.21, z. 3 (2023)

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Synthesis and characterization of Fulvestrant and Paclitaxel conjugates with polyamidoamine dendrimer fourth generation
(Publishing Office of the University of Rzeszow, 2023-09) Wróbel, Konrad; Wołowiec, Stanisław
Introduction and aim. Poorly soluble anticancer drugs can be attached covalently into biologically inert macromolecule in order to administrate a drug as water soluble form. It was proven that covalent linkers, for instance amide or carbamate bonds are susceptible to hydrolysis. Thus the attached drug can be released from the conjugates in tissue, specifically within the targeted cell. We aimed at construction of water soluble conjugates of Fulvestrant and Paclitaxel with PAMAM G4 dendrimer. In order to obtain water soluble conjugates the amine groups were substituted with R-glycidol. Material and methods. Polyamidoamine dendrimer of fourth generation was synthesized and examined by detailed NMR analysis in water and in DMSO. The conjugates were covalently linked to amine groups of PAMAM after activation of Fulvestrant 17-OH group with 4-nitrophenylchloroformate and activation of end-carboxyl group of Paclitaxel succinate. Results. The method of binary conjugate PAMAMG4-Fulvestrant-Paclitaxel synthesis was elaborated and the product was characterized by physicochemical methods. Conclusion. The glycidylated PAMAMG4-Fulvestrant-Paclitaxel conjugate is better soluble in water than unconverted drugs.
Biochemical and cellular (liver and kidney) restorative properties of garlic (Allium sativum) aqueous extract in cow brain-induced hypercholesterolemic model Swiss albino mice
(Publishing Office of the University of Rzeszow, 2023-09) Kundu, Swarup Kumar; Khan, Mohammad Abu Hadi Noor Ali; Das, Shonkor Kumar
Introduction and aim. Garlic is one of the most popular traditional medicinal herbs which has a number of desirable health benefits. The study was designed to depict the improvement of serum biochemical parameters as well as the histomorphological recovery potential of garlic aqueous extract in hypercholesterolemic mice. Material and methods. A total of thirty Swiss albino mice weighing 24±5g and aged 5 weeks were randomly divided into three groups. Group A: supplied standard mice pellet and water; Group B: standard mice pellet + hypercholesterolemic diet (cow brain: 2 g/kg b.w.t.); and Group C: standard mice pellet + hypercholesterolemic diet (cow brain: 2 g/kg b.w.t.) + garlic extract (25 ml/kg b.w.t.). After four weeks of experimental tenure, samples (blood, liver, and kidney) were collected from each group of mice for serum biochemical analysis and histomorphological study. Results. Compared with hypercholesterolemic mice, total cholesterol (TC), triglyceride (TG) concentration, and low-density lipoprotein (LDL) levels significantly decreased respectively by 7%, 20% and 48% along with high-density lipoprotein (HDL) levels significantly increased by 47% in garlic extract supplemented group. Based on the histological evaluation in the liver sample of group C, both portal and central veins were normal, and fat droplets were not found in the hepatocytes which were found in the liver of group B. On the other hand, unchanged renal cortex, glomerulus, Bowman’s space, and kidney tubules were seen in group C. Conclusion. Therefore, the above findings of the present research would assist to provide affirmation about the cholesterol-decreasing and cellular restoration potentiality of garlic aqueous extract.
Evaluation of nonpharmacological nursing practices related to thirst and the thirst of patients in the intensive care unit
(Publishing Office of the University of Rzeszow, 2023-09) Çelik, Sevim; Şengül, Münevver; Karahan, Elif
Introduction and aim. Thirst is a significant symptom and stressor among patients in the intensive care unit. The aim of this study is to assess the severity of thirst and associated symptoms experienced by patients in the intensive care unit, and to evaluate the nursing practices related to addressing thirst. Material and methods. This descriptive and correlational study involved a total of 66 patients in the intensive care unit. Severity of thirst experienced by these patients was assessed using a numeric rating scale. The nursing practices related to assessing thirst severity on admission to the unit, on the third day, and on the seventh day were also recorded. Results. Our findings showed a statistically significant increase in the levels of thirst, dry mouth, bad taste and odor in the mouth, as well as sensitivity and dryness in the throat among patients on the seventh day of hospitalization (p<0.05).Among nursing interventions, communication with the patient was the most frequently applied intervention during the seven-day period, with a range of 98.5% to 100%. biochemical control (100%), ventilation of the unit (100%), and temperature regulation (100%) were also frequently applied. Conclusion. The patients had all the symptoms of thirst.The frequency of nursing interventions increased in parallel with the severity of thirst.
Hygienic assessment of the occurrence and development of emotional burnout syndrome among medical students and its prevention
(Publishing Office of the University of Rzeszow, 2023-09) Chorna, Valentyna; Syrota, Hanna; Syrota, Mariia; Khliestova, Svitlana; Poliarush, Vlada; Hudzevych, Lyudmyla
Introduction and aim. Emotional burnout syndrome has become increasingly common in recent decades, regardless of the field of professional activity. The purpose of our study was to compare the prevalence of emotional burnout in medical students of Vinnytsia National Medical University before the beginning of the academic semester and during the passing of exams. Material and methods. An anonymous, voluntary survey before the start of study was taken by 300 students, among them 82.3% were women, 17.7% were men. Results. During the exams, 362 students took part, including 76.2% women and 24.1% men. According to the results of the study, the proportion of the “average” degree of exhaustion increased in second-year students by 15.6%; third-year students by 44.4%. The “high” degree of emotional exhaustion according to the results of the study before the start of training was found in male students of the third year – 44.4% and 36.4% of male students of the sixth year. During the exams, the rate of “high” emotional exhaustion was observed in first-year students, increasing from 12.5% to 18% and in sixth-year students from 36.4% to 50%. Conclusion. Thus, it was found that female students are the most adapted to the educational load, to passing exams, which affects the psychosomatic state of future doctors.
The effect of foot baths on foot pain and leg edema of nursing students during clinical training
(Publishing Office of the University of Rzeszow, 2023-09) Çelik, Sevim; Cerrah, Gülbahar; Gürel, Berşan; Sağlık, Cavide; Albayrak, İrem
Introduction and aim. Edema and pain may occur in the lower extremities due to the long-term standing work of nursing students and the stress they experience. In this study, the aim was to determine the effect of foot baths applied after clinical practice on foot pain and leg edema in nursing students. Material and methods. This randomized controlled study was carried out with second year nursing students. The intervention group received a foot bath (including immersion in water and massage). No intervention was performed on the control group. The data was collected using a survey form, edema follow-up form, visual analog scale, and foot bath equipment. Results. Edema levels in the right tibia decreased statistically on the 1st and 2nd days after the foot bath compared to the values measured after nurses performed clinical practice, while the edema level in the left tibia decreased significantly in the first and fourth weeks (p<0.05). The right and left foot pain scores in the intervention group increased in the evening of the day after the clinical practice compared to before clinical practice, and pain scores decreased statistically significantly after foot bath (p<0.001). The foot pain scores expressed by the students in the first week increased continuously (p<0.001). Conclusion. The study showed that a foot bath performed after clinical practice were effective for easing foot pain and leg edema.
Nutritional knowledge about the Mediterranean diet and its practical application among students in Poland
(Publishing Office of the University of Rzeszow, 2023-09) Karlik, Sandra; Dereń, Katarzyna
Introduction and aim. The popularity of the Mediterranean diet is increasing and following it has many health benefits, including improving mental well-being. The aim of the study was to assess the nutritional knowledge about the Mediterranean diet and its practical application among students in Poland. Material and methods. The study assessed a group of 313 students in Poland. The research tool was a questionnaire that focused on knowledge about the Mediterranean diet. Results. The study showed that in terms of knowledge of the Mediterranean diet, students scored on average 6.5±3.2 points (on a scale 0–11). When it comes to dietary compliance, the average score was 6.3±2.4 points (scale 1–13 points). The better the knowledge of the diet, the better the compliance with its rules. Statistically, the analysis showed that there is a significant relationship between the age and/or academic degree of the students and their higher level of knowledge. The greater compliance with Mediterranean eating patterns was influenced by the location, age, or education of the respondents. Conclusion. The study shows that the surveyed group of students in Poland has only an average level of knowledge and compliance with the Mediterranean diet.
The correlation between nursing students’ levels of fear and stress related to the COVID-19 pandemic and their compliance with standard precautions
(Publishing Office of the University of Rzeszow, 2023-09) Yilmaz Kurt, Fatma; Alankaya, Naile; Atay, Selma; Efil, Sevda
Introduction and aim. University students have been demonstrated in the literature to be a group particularly vulnerable to mental health problems during the COVID-19 pandemic. The aim of this study was to examine the correlation between the fear and anxiety levels of nursing students regarding the COVID-19 pandemic and their compliance with standard precautions. Material and methods. The sample consisted of 509 volunteer students. Data were collected using a Personal Information Form, the Fear of COVID-19 Scale (FCV-19S), the COVID-19 Anxiety Scale (CAS) and the Compliance with Standard Precautions Scale (CSPS). Results. The FCV-19S, CAS, and CSPS mean scores of the students were respectively 17.49±5.24 1.99±3.54 and 13.46±3.61. There was a moderate correlation (p<0.05) between the FCV-19S and CAS of the students, but no correlation was detected between CSPS and FCV-19S (p>0.05) and CAS (p>0.05). Conclusion. It was determined that students had a moderate fear of COVID-19 and a low level of anxiety over COVID-19. However, fear of COVID-19 and COVID-19 anxiety levels were not correlated with compliance with standard precautions.
Estimation of age by mental foramen using CBCT in central India
(Publishing Office of the University of Rzeszow, 2023-09) Bose, Sourav; Sur, Jaideep; Khan, Fatima; Dewangan, Deeplaxmi; Paul, Sushmita; Sawriya, Ekta; Roul, Ayesha
Introduction and aim. This study aims to estimate the age of a population in Central India by analyzing the mental foramen using cone beam computed tomography (CBCT). The objectives of the study are to determine the parameters for age determination and study bilateral variations in mental foramen dimensions using CBCT. Material and methods. One hundred and twenty CBCT scans, HD LED monitor, GALAXIS GALLIEOS viewer. Results. Results from the study show significant values for various parameters such as the upper and lower borders of the mandible and mental foramen. Bilateral variations were also observed. The age regression model indicates a significant correlation between estimated and original ages for individuals aged between 31 to 50 years. While the study only analyzed five parameters of the mental foramen, it suggests that a more comprehensive assessment of mental foramen parameters with a larger sample size can yield more definitive results for age determination. Conclusion. As only five parameters of mental foramen had been assessed in this retrospective study, so a comprehensive assessment of various other parameters of mental foramen with an increased sample size may be done for more definitive results for gender and age determination.
Factors affecting work-life balance and psychological resilience levels of nurses working in internal clinics during COVID-19
(Publishing Office of the University of Rzeszow, 2023-09) Korkmaz Aslan, Tuba; Burucu, Rukiye; Akdoğan, Yunus
Introduction and aim. COVID-19 intensity has affected both the psychology of the nurses and the balance established between their work and social lives. In this study, it was aimed to examine the work-life balance and psychological resilience levels of nurses. Material and methods. Four Hundred and seventy two nurses, working in various hospitals and internal units in Turkey, voluntarily participated in the study. Data was collected online using the Work-Life Balance Scale, Brief Psychological Resilience Scale, and the Personal Information Form. Results. The sub-dimensions of the work-life balance scale include allocation of time for yourself (β=1.892; p<0.001), life merely being based on work (β=-0.513; p<0.05) and work-life balance; affect the psychological resilience score (β=-0.364; p<0.05). Based on this, devoting time for yourself has a positive effect on psychological resilience, while others have a negative effect. The total score of the nurses on work-life balance is 51.51±7.22 and their psychological resilience score is 15.27±3.93. Conclusion. Psychological resilience is affected by educational status, marital status, having children, and working schedule; work-life balance is affected by educational status, marital status, having children, income levels, and working schedule; while work-life balance sub-dimensions are affected by education, marital status, having children, income levels, place of work and working schedule. Both work-life balance and its sub-dimensions affect the psychological resilience of nurses.
Are our sub-centers prepared enough to tackle high-risk pregnancies? A cross-sectional survey from Southern Rajasthan, India
(Publishing Office of the University of Rzeszow, 2023-09) Paliwal, Bharti; Sharma, Rupa; Rao, Rajath
Introduction and aim. Sub-centers (SC) are the first contact point with the community with auxiliary nurse midwife (ANM) as the instrument, delivering all the primary health care services. The SCs are under constant criticism for their inability to deliver quality services. This study assessed the preparation of facilities available at the SC to manage high-risk pregnancies (HRP) and to compare the same between rural and tribal blocks of the selected district. Material and methods. This health facility-based cross-sectional observational study was done for 6 months among 276 rural and tribal SC of the Udaipur district by a two-stage random sampling method using an observational checklist to assess the infrastructure and logistics of SCs. Data were analyzed using SPSS 20. Results. The study covered 264 (95.7%) non-24x7 SCs and 12 (4.3%) 24x7 SCs. Only one-third SCs, 93 (33.6%) were situated at the center of the village. Only 151 (54.7%) SCs had attached ANM quarters. All 24x7 SCs and 78.4% of non-24x7 SCs had adequate equipment and infrastructure. Conclusion. Most of the subcentres’ infrastructure and functional equipment was equipped to tackle HRP. Rural SC adhered more than tribal. Most HRPs were tracked and referred to higher centers. Unless we emphasize strengthening SCs, the dream of a healthy nation will remain obscure.
The effect of uniform wearing and candle lighting ceremony on nursing students’ perspective on the profession – a qualitative study
(Publishing Office of the University of Rzeszow, 2023-09) Buldan, Özge; Harmanci, Pinar
Introduction and aim. The aim of this study was to investigate the effect of the Uniform Wearing Ceremony and the Candle Lighting on nursing students’ perceptions of the profession. Material and methods. A qualitative, phenomenological method was used to design the study. The standardised criteria for reporting qualitative research with 32 elements were used for the research. The study was conducted with 60 students who volunteered to participate in the study by not selecting a sample of first year nursing students from a university in Northern Turkey. Interviews were conducted 3 times for approximately 20-40 minutes. Results. In this study, the rate of students who perceived the Uniform Wearing Ceremony as positive was as high as (n=42), the rate of those who thought that the uniform had an effect on the image of the nursing profession was 88.3%, and the rate of those who considered nursing as a respected profession was (23%). Conclusion. Nursing students who participated in the study stated that the effect of the Uniform Wearing Ceremony and the Candle Lighting Ceremony positively influenced their perception of the profession and that the uniform had an impact on the image of the nursing profession.
Effect of meditation on premenstrual syndrome in female medical students
(Publishing Office of the University of Rzeszow, 2023-09) Kaur, Harminder; Kaur, Nimarpreet; Akula, Gangadhar Reddy; Kodidala, Satyanath Reddy
Introduction and aim. A symptom complex of cyclic irritability, depression and lethargy is known as the premenstrual syndrome (PMS). Since ages women suffered from PMS. As varied as the etiology, innumerable treatment modalities have been put forward for PMS. Stress is accompanied most closely associated in PMS. Practicing yoga and meditation significantly important for PMS symptoms in reducing its symptoms and period crams as well. The present study aims the impact of meditation in people with PMS. The aim of the study was to see any effect of Shavasana (meditation) training on stress parameters in premenstrual syndrome in female medical students. Material and methods. The present study was approved by institutional ethical committee. Thirty clinically healthy female medical students who were suffering from PMS selected using a premenstrual questionnaire. The values of heart rate, systolic and diastolic blood pressure, and serum cortisol were measured before meditation. Subjects were then taken through Shavasana (meditation) session for 4 weeks at the same time daily. On the last day of meditation session all above parameters were again recorded and the data was analyzed statistically. Results. The baseline values of all parameters in premeditation session compared to post meditation session. The basal SBP, DBP and HR of female medical students with PMS were significantly higher in pre meditation session than post meditation session with p value of SBP=0.0002, DBP=0.0001, HR<0.0001 respectively which indicated the presence of stress. Following a 4weeks of Shavasana meditation a significant fall in baseline SBP, DBP, HR and the serum Cortisol value was observed. Conclusion. These findings proves that Shavasana is an effective treatment modality to get rid of stress during premenstrual phase.
Evaluation of salivary pH and flow rate among exam going students of Karpaga Vinayaga Institute of Dental Sciences
(Publishing Office of the University of Rzeszow, 2023-09) Perumal, Raghupathy; Balasubramanian, Sasirekha; Subramaniam, Gokulapriya; Krishnan, Ishwariya; Shanmugam, Maheshwari; Santhosh, Kalaiselvi
Introduction and aim. The central nervous systems control salivary pH and Flow; hence it is considered as stress biomarker. To correlate the relationships linking test performance and the cognitive along with affective aspects for the stress of the exams, flow rate and pH levels of saliva. Material and methods. Cross-sectional research was carried out on the day of their final exam and after three months. 90 dental college students provided saliva samples for measuring pH and salivary flow rate. The saliva was collected to measure stress, anxiety, and wellbeing. Results. Salivary flow and pH were increased in the after-exam period. This is mostly due to less threat, stress, and anxiety perception. Conclusion. According to this study, perceived stress can affect salivary flow rate and pH levels, which can be used to gauge the degree of physiological reactions accurately, conveniently, and affordably to tests and variable realistic stresses.
A study of knowledge attitude practices and identification of perceived barriers towards screening for diabetic retinopathy amongst diabetics in an industrial area in western Maharashtra
(Publishing Office of the University of Rzeszow, 2023-09) Bakare, Prachi; Sethi, Sejal; Mushtaq, Iqra; Maheshgauri, Rupali; Magdum, Renu; Modani, Neha Kamalkishor; Gogate, Parikshit
Introduction and aim. Diabetic retinopathy (DR) screening is first step in prevention of diabetic retinopathy related ocular morbidity. The aim of the study was to assess the gaps in the knowledge and awareness and evaluate its effects on the attitude and practice in known diabetic patients and to assess any anticipated barriers and its association with knowledge, attitude and practices. Material and methods. A closed-ended questionnaire was given to 112 diabetics who met the inclusion criteria and visited a tertiary eye hospital in western Maharashtra. The purpose of the questionnaire was to assess knowledge, attitude and practices and perceived barriers to the study of DR. The statistical analysis was done on SPSS software. Results. In our study, 73.4% did not know about DR, suggesting poor awareness about the disease, 59.5% did not feel the need for regular eye checkup. 67 (61.1%) had no knowledge about blood sugar control level and lipid control for effective control of DR, 89 (79.5%) of participants did not know about effective treatment options. Moreover, 74 (66.1%) participants were advised for DR screening by physician, while 60 (53.5%) were willing to get screened, negative attitude was not getting screened when vision is good seen in 87 (79.1%) participants. Furthermore, 84 (75%) patient think eye checkup are expensive, 66% people believe availability of doctor is an issue. 60 (54.5%) think that eye checkups are time consuming. Conclusion. Our study demonstrated, that Spearman’s correlation coefficient between knowledge and awareness and based on attitude and practice, is 0.54, and that this is statistically significant (p<0.01). Our study has shown poor awareness and knowledge about the disease thus affecting attitude and practices, eye screening is considered expensive has been pointed out a major barrier in this study.
Cancer patients’ attitudes towards holistic complementary and alternative medicine in the management of sleep problems
(Publishing Office of the University of Rzeszow, 2023-09) Baykal, Dilek; Dedeoğlu Demir, Burcu; Yildirim, Dilek
Introduction and aim. Sleep problems are frequently experienced in cancer patients and complementary and alternative medicine (CAM) is solve the problem. However, patients’ attitudes towards this practice are crucial. This study was purpose to investigate the attitudes of cancer patients towards CAM practices in the management of sleep problems. Material and methods. This cross-sectional. and descriptive study was conducted between February-June 2020, on 140 cancer patients in oncology/haematology clinics, three different hospitals in Istanbul. Data were collected by using the Information Form, “Richard Campbell Sleep Questionnaire and The Attitudes towards Holistic Complementary and Alternative Medicine scale”. Results. It was found that the patients had problems with sleep in general 42.74±21.31, mostly in the aspect of the quality of sleep 36.28±26.1. It was determined that stage IV cancer, education and income level of patients affect sleep problems. While female holistic health attitudes were more negative and, their attitudes towards CAM were positive. It was found in the analysis of variance that was performed to determine the difference between the mean scores towards sleep problems of patients in different stages (F=3.062; p<0.05). Conclusion. It was found that cancer patients usually had sleep problems, and their attitudes towards CAM practices were positive.
Evaluation of the relationship between job satisfaction and professional behaviors in pediatric nurses
(Publishing Office of the University of Rzeszow, 2023-09) Dinç, Fatma; Yıldız, Dilek
Introduction and aim. Pediatric nurses play an important role in ensuring quality healthcare through job satisfaction and professional behaviors. This study aims to examine the relationship between job satisfaction and professional behaviors in pediatric nurses. Material and methods. This was a descriptive and cross-sectional study.The sample of the study consisted of 244 pediatric nurses who worked in tertiary university hospitals in Turkey and agreed to participate in the study. Data were obtained through face-to-face interviews using a personal information form, the job satisfaction scale for nurses (JSSN), and the behavioral inventory form for professionalism in nursing (BIPN). Data were analyzed using the SPSS 22.0 software and evaluated using descriptive statistics, independent t-tests, one-way ANOVA, Pearson correlation, and simple linear regression analysis. Results. The nurses’ JSSN and BIPN means scores were 3.42±0.59 and 5.69±4.05, respectively. A statistically significant moderate positive relationship was found between the pediatric nurses’ professional behaviors and job satisfaction (R=0.342; p<0.001). The regression analysis revealed that professional behaviors significantly and positively influenced job satisfaction in pediatric nurses (β=0.050; p<0.001). Conclusion. This study found that pediatric nurses had a moderate level of job satisfaction and a low level of professional behaviors, and as their professional behavior increased, their job satisfaction also increased.
Predictors of hospitalization in patients presenting to emergency department with an acute exacerbation of COPD – a single-center study in Turkey
(Publishing Office of the University of Rzeszow, 2023-09) Sanalp Menekşe, Tuğba; Sert, Ekrem Taha
Introduction and aim. In this study, we evaluated parameters that might be associated with hospitalization in patients admitted to the emergency department (ED) with an acute exacerbation of chronic obstructive pulmonary disease (AECOPD). Material and methods. Patients with COPD who presented to ED due to AECOPD between January 1, 2020 and December 31, 2021 were included in the study. Patient data were obtained from the hospital database. Univariable and multivariable logistic regression methods were used to identify the relationship between hospitalization and clinical parameters. Results. The study included 237 patients divided into two groups: inpatients (n=124) and outpatients (n=113). We found significant differences between the two groups in terms of temperature, oxygen saturation, respiratory rate, C-reactive protein, white blood cell count, procalcitonin, albumin, arterial blood pH, pCO 2 , and non-invasive mechanical ventilation (NIMV) requirement. Multivariable logistic regression analysis showed that body temperature [odds ratio (OR):1.62;95% confidence interval (CI):1.21–4.91; p<0.001], oxygen saturation (OR:0.73, 95% CI:0.39-0.94, p<0.001), respiratory rate (OR:1.96; 95% CI: 1.07–6.14; p<0.001), albumin (OR:0.71; 95% CI:0.41–0.93; p=0.042), procalcitonin (OR:2.93; 95% CI:1.22–4.84; p<0.001), arterial blood pH (OR:0.78; 95% CI:0.29-0.91; p=0.038), pCO 2 (OR:2.45; 95% CI:1.24–4.65; p<0.001), and NIMV requirement (OR:2.31; 95% CI:1.41–5.13; p<0.001) were the independent predictors of hospitalization. Conclusion. Our findings may help identify patients who will require hospitalization at an early stage.
Role of sulfide anion in the development of chronic alcoholic hepatitis under the conditions of modulation of adenosine monophosphate kinase – a correlational study
(Publishing Office of the University of Rzeszow, 2023-09) Mykytenko, Andrii; Akimov, Oleh; Shevchenko, Oleksandr; Neporada, Karine
Introduction and aim. Hydrogen sulfide (H 2 S) has attracted the attention of researchers as a novel signaling molecule that affects vascular metabolism, immune function, stress and inflammation. It plays an important role in pathophysiological disorders under the conditions of the development of obesity, diabetes, non-alcoholic fatty liver disease and cardiovascular diseases. The purpose of this work is to establish correlation ratios of H 2 S concentration with markers of oxidative-nitrosative stress and extracellular matrix metabolism of the liver during chronic alcoholic hepatitis modeling and AMPK modulation by phenformin and doxorubicin. Material and methods. The experiments were performed on 36 white, sexually mature male Wistar rats, weighing 180-220 g. Alcoholic hepatitis was modelled by alcohol administration, on the background of alcoholic hepatitis animals received phenformin orally at a dose of 10 mg/kg or doxorubicin at a dose of 1.25 mg/kg intraperitoneally. Statistical processing of the results of biochemical studies was carried out using the non-parametric method of Spearman to determine correlations. Results. H 2 S during alcoholic hepatitis inversely proportionally strongly correlates with the concentration of nitrites, oxyproline and arginase activity. Phenformin administration during alcoholic hepatitis leads to formation of inversely proportionally strongly correlation of H 2 S with the production of superoxide anion radical, the concentration of malondialdehyde, activities of constitutive NO-synthases, nitrite reductases, nitrate reductases, and arginase. Doxorubicin administration during alcoholic hepatitis leads to formation of directly proportional strongly correlation of H 2 S with the activity of constitutive NO-synthases, nitrite reductases, nitrate reductases. Conclusion. Administration of phenformin or doxorubicin expands correlations between H 2 S and indicators of oxidative-nitrosative stress.
The effect of different blood groups on visual evoked potentials
(Publishing Office of the University of Rzeszow, 2023-09) Eski, Mehmet Tahir; Yabalak, Ahmet; Şahan, Halime; Ayaslı, Alper Aziz Hüdai; Sezer, Taha
Introduction and aim. Purpose of the study is to determine whether it is required to use different standards when evaluating visual evoked potential (VEP) measurements of healthy individuals with different blood groups. Material and methods. The study consisted of healthy individuals with different blood groups who have applied to the ophthalmology and neurology outpatient clinic of Düzce University Medical Faculty from January to December 2022. The patients went through detailed ophthalmologic examination and VEP test and only the ones with normal results were included to the study. Results. The study consisted of 119 individuals, with a blood group distribution of 30 A, 29 B, 30 AB and 30 O. VEP latency and amplitude changes were compared and no significant difference was observed within 4 groups in terms of P100 and N70 latency and amplitudes. There was N70 latency prolongation in Rh- group and this difference was found to be statistically significant (p=0.009). Rh+ group was found to be high in terms of P100 amplitudes and this was considered statistically significant (both p=0.023). Conclusion. There was no statistically significant difference in the VEP parameters of the individuals with the ABO blood groups hence same VEP normal values can be used for ABO blood groups.
Nursing care for symptoms seen in patients undergoing palliative surgery – a retrospective study
(Publishing Office of the University of Rzeszow, 2023-09) Uçar, Özge; Çelik, Sevim; Karahan, Elif; Altıntaş, Sibel
Introduction and aim. Palliative care is an approach to improve the quality of life of patients and their families facing problems associated with life-threatening illnesses or old age, to manage their pain, distress, and other symptoms, improving their quality of life, and providing psychological support. This study was designed to identify the care practices planned by nurses for the health issues of palliative surgical patients. Material and methods. This is a retrospective, cross-sectional, descriptive study. The data was collected from digital records of the two state hospitals in the Western Black Sea Region of Turkey between January 2019 and January 2020. The research was completed with a total of 391 data of patients undergoing palliative surgery. Frequency and percentage distributions were used in descriptive statistics. Results. The frequency of symptoms observed in patients were determined as cough and sputum (81.8%), dehydration (73.9%), dyspnea (71.9%), fatigue (49.9%), loss of appetite-weight (49.9%), insomnia (44%), pain (37.6%), nausea (29.2%), and constipation (23.8%). The planned nursing diagnoses for these symptoms were identified as risk for falls, imbalanced nutrition, risk for impaired skin integrity, risk for infection, risk for aspiration, deficient knowledge, risk for impaired respiratory function, constipation, ineffective airway clearance, pain, risk for deficient fluid volume, sleep deprivation, impaired gas exchange respectively. Conclusion. This study highlights the insufficient planning of nursing care for the symptoms of palliative surgical patients receiving palliative care in our country. Therefore, it is recommended that palliative care nurses be supported with in-service training on appropriate care planning topics.

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